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您的检索式：作者名="Michael Valentini"
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| 1 | Subcellular Redistribution of Root Aquaporins nduced by Hydrogen Peroxide显示文摘Aquaporins 是调停的水隧道蛋白质在开发期间或响应环境压力调整房间膜水渗透。现在的工作集中于血浆膜的氧化导致压力的再分配内在的蛋白质(果仁) aquaporinsfrom 血浆膜(下午) 到细胞内部的膜。这个过程在 Arabidopsis 根被调查。蔗糖密度坡度 centrifugation 显示出根的那暴露到 0.5mM H 2 O 2 在 15min 以后在几个丰富的果仁相当或相同的事物的下午部分导致重要弄空。由单个粒子的追踪和荧光关联词光谱学的分析显示出那,在表皮的房间的 PM, H 2 O 2 处理在 prototypal AtPIP2 的一种荧光灯地标注的形式的密度在侧面的运动和减小导致增加; 1 isoform 分别地。AtPIP2 的合作表示分析; 1 与 endomembrane 标记揭示了那 H 2 O 2 扳机 AtPIP2;在迟了的 endosomal 分隔空间的 1 累积。一生分析证实果仁的高稳定性在氧化压力条件下面被维持,建议那 H 2 O 2 进一步为下午 aquaporinswithout 的细胞内部的隐遁触发机制降级。除了 aquaporins 的细胞的规定的信息,这研究提供新奇、互补的卓见进动态改变在氧化压力回答期间种内部膜。 | Michael M. Wudick Xiaojuan Li Valeria Valentini Niko Geldner Joanne Chory Jinxing Lin Christophe Maurel Doan-Trung Luu | 2015 | Molecular Plant2015，8，7： | 0 |
| 2 | High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients:A proof-of-concept study显示文摘BACKGROUND One third of coronavirus disease 2019(COVID-19)patients have gastrointestinal symptoms.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA has been detected in stool samples of approximately 50%of COVID-19 individuals.Fecal calprotectin is a marker of gastrointestinal inflammation in the general population.AIM To investigate if fecal calprotectin correlates with SARS-CoV-2 intestinal shedding in COVID-19 patients with pneumonia.METHODS Patients with SARS-CoV-2 pneumonia admitted to the Infectious Disease Unit(University Hospital of Trieste,Italy)from September to November 2020 were consecutively enrolled in the study.Fecal samples were collected and analyzed for quantification of fecal calprotectin(normal value<50 mg/kg)and SARS-CoV-2 RNA presence by polymerase chain reaction(PCR).Inter-group differences were determined between patients with and without diarrhea and patients with and without detection of fecal SARS-CoV-2.RESULTS We enrolled 51 adults(40 males)with SARS-CoV-2 pneumonia.Ten patients(20%)presented with diarrhea.Real-time-PCR of SARS-CoV-2 in stools was positive in 39 patients(76%),in all patients with diarrhea(100%)and in more than two thirds(29/41,71%)of patients without diarrhea.Obesity was one of the most common comorbidities(13 patients,25%);all obese patients(100%)(P=0.021)tested positive for fecal SARS-CoV-2.Median fecal calprotectin levels were 60 mg/kg[interquartile range(IQR)21;108];higher fecal calprotectin levels were found in the group with SARS-CoV-2 in stools(74 mg/kg,IQR 29;132.5)compared to the group without SARS-CoV-2(39 mg/kg,IQR 14;71)(P<0.001).CONCLUSION High fecal calprotectin levels among COVID-19 patients correlate with SARSCoV-2 detection in stools supporting the hypothesis that this virus can lead to bowel inflammation and potentially to the‘leaky gut’syndrome. | Verena Zerbato Stefano Di Bella Mauro Giuffrè Anna Wladyslawa Jaracz Ylenia Gobbo Diego Luppino Paolo Macor Ludovica Segat Raffaella Koncan Pierlanfranco D'Agaro Michael Valentini Lory Saveria Crocé Maurizio Ruscio Roberto Luzzati | 2021 | World Journal of Gastroenterology2021，27，22： | 0 |
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