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| 1 | 人类面临的甲基汞暴露和健康影响:世界范围的关注显示文摘本文基于现有的文献资料,突出了当前的认识并且识别在甲基汞暴露、健康影响、危害评估方面还未解决的问题并且得出意见一致的结论。甲基汞是一种烈性毒素,通过水中的食物链在生物体内积累和富集,使世界各地各种社会经济阶层内那些常吃食肉鱼类或者以鱼类为主食的人置于危险境地。甲基汞对神经的发育危害已经成为制定风险评估和公共健康政策的基础。尽管在暴露的新指示生物、影响甲基汞吸收和毒性的因素、毒物动力学、成年人神经病学和心脑血管的影响,来自大量海水鱼和淡水鱼以及食鱼鱼类的营养收益和危害,各方面的知识还有许多研究断层,研究小组认为要保护人类健康,必须尽一切努力来减少并消除暴露源。 | Donna Mergler Henry A.Anderson Laurie Hing Man Chan Kathryn R.Mahaffey Michael Murray Mineshi Sakamoto Alan H.Stern 甲基汞的健康风险和毒物学影响专家组 | 2007 | AMBIO-人类环境杂志2007，36，1： | 12 |
| 2 | 冲突与支持影响情侣依恋的文化差异显示文摘采用香港和美国的被试,运用亲密关系经历量表、冲突量表和社会支持量表,考察了冲突和支持对于情侣依恋影响的文化差异。结果发现,当以依恋焦虑为因变量时,冲突、支持和文化×冲突×支持都是显著的预测变量;当以依恋逃避为因变量时,仅文化和文化×支持是显著的预测变量。由此可见,文化影响冲突×支持与依恋焦虑的关系:在香港,情侣之间的冲突和支持各自对于依恋焦虑的作用在很大程度上相互抵消;在美国,情侣之间冲突的负面影响比支持的积极影响要强,冲突×支持越高,依恋焦虑越高。对于依恋逃避,文化差异仅调节支持与依恋逃避的关系:在香港,支持对依恋逃避的影响要比美国强。整个研究表明,对不同类型的情侣依恋,文化的调节作用不同。 | 陆爱桃 张积家 Michael Harris Bond 张学新 Michael Friedman Chan Ching | 2009 | 心理学报2009，41，6： | 9 |
| 3 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 4 | 火灾高温下硬化水泥浆的化学分解特征显示文摘因高性能混凝土的抗火性与高温下硬化水泥浆(HCP)的化学分解有密切关系,为获得对火灾高温所致HCP化学分解特征的定量理解,对HCP试样进行了400~800℃的高温处理,采用XRD测定C-S—H化学分解动力学.结果表明,C—S—H分解始于560℃,但仅在600℃以上其分解才变得显著,且分解速度随温度升高而急剧增大.尽管C—S—H的分解可造成混凝土强度的显著下降,但这种分解主要发生在600℃以上温度范围内,故对更低温度下发生的高温爆裂基本没有影响.分别建立了在600、700和800℃温度下C—S—H分解反应动力学方程. | 朋改非 王金羽 CHAN Y N Sammy Anson Michael | 2009 | 南京信息工程大学学报(自然科学版)2009，1，1： | 9 |
| 5 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 6 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 7 | Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma显示文摘Allergen-specific immunotherapy(allergen-SIT)is a highly effective treatment for children with allergic asthma(AA),an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens.T helper cells and secreted cytokines play important roles in the pathogenesis of asthma,and epigenetic modulation controls genes important for T cell development and cytokine expression.This study evaluated T helper cell-secreted cytokines and DNA methylation patterns in children treated with Dermatophagoides pteronyssinus(Der p)allergen-SIT.Our results showed that after Der p challenge,peripheral blood mononuclear cells(PBMCs)from the SIT group,compared with the non-SIT AA group,produced lower levels of IL-4,IL-5 and IL-2.The SIT group,compared with the AA group,exhibited decreased sensitivity to the Der p allergen,concurrent with IL-4 down-modulation due to increased promoter DNA methylation,as estimated in PBMCs.Our results showed that SIT decreased IL-4 and IL-5,and inhibited T cell proliferation,by inhibiting IL-2 production after the specific allergen challenge.These results suggest that decreased IL-2 production and increased IL-4 cytokine promoter methylation is a potential mechanism of Der p-specific allergen desensitization immunotherapy. | Chuang-Ming Wang Chia-Bin Chang Michael WY Chan Zhi-Hong Wen Shu-Fen Wu | 2018 | Cellular & Molecular Immunology2018，15，11： | 5 |
| 8 | 乌司奴单抗改善中、重度斑块状银屑病患者健康相关生活质量和临床疗效观察显示文摘目的:评估乌司奴单抗对中国3期、双盲、安慰剂对照临床(LOTUS)研究患者健康相关生活质量(HRQoL)的影响。方法:共322例患者,在第0周和第4周随机接受乌司奴单抗45mg(n=160)或安慰剂(n=162);第12周和第16周安慰剂组交叉使用乌司奴单抗,而乌司奴单抗组则在第16周继续使用乌司奴单抗。第12周HRQoL终点包括皮肤病生活质量指数(DLQI)评分较基线的变化、单个DLQI域的变化、DLQI评分为0分或1分的患者比例以及获得有临床意义DLQI改善(评分降低≥5分)的患者比例。结果:乌司奴单抗治疗患者12周时DLQI评分较基线的改善(-9.3分)显著优于安慰剂组(-1.9分)(P<0.001)。同样,乌司奴单抗治疗后DLQI≤1分的患者比例显著高于安慰剂组(42.6%vs 10.7%,P<0.001),乌司奴单抗组和安慰剂组治疗后分别有71.5%和29.6%的患者DLQI降低≥5分(P均<0.001)。乌司奴单抗治疗患者12周时单个DLQI域与安慰剂相比显著改善(P<0.001)。乌司奴单抗组DLQI的改善在治疗28周内持续存在。交叉接受乌司奴单抗的安慰剂组患者,与最初随机接受乌司奴单抗治疗的患者相比,HRQoL改善程度类似。结论:乌司奴单抗显著改善了中国中至重度斑块状银屑病患者的HRQoL。 | 朱学骏 郑敏 Michael Song Chenglong Han Daphne Chan Y.K.Shen 王宝玺 | 2014 | 临床皮肤科杂志2014，43，9： | 4 |
| 9 | Effects of nanotopography on stem cell phenotypes显示文摘Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues.In the stem cell niche,stem cell-extracellular matrix(ECM)interactions are crucial for different cellular functions,such as adhesion,proliferation,and differentiation.Recently, in addition to chemical surface modifications,the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs.This review describes the influence of nanotopography on stem cell phenotypes. | Rajeswari Ravichandran Clarisse CH Ng Casey K Chan Michael Raghunath Seeram Ramakrishna | 2009 | World Journal of Stem Cells2009，1，1： | 3 |
| 10 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 11 | Spectral Analysis for HSS Preconditioners显示文摘In this paper,we are interested in HSS preconditioners for saddle point lin- ear systems with a nonzero(2,2)-th block.We study an approximation of the spectra of HSS preconditioned matrices and use these results to illustrate and explain the spectra obtained from numerical examples,where the previous spectral analysis of HSS precon- ditioned matrices does not cover. | Lung Chak Chan Michael K. Ng Nam Kiu Tsing | 2008 | Numerical Mathematics(Theory,Methods and Applications)2008，1，1： | 3 |
| 12 | Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study显示文摘 | Yahya Shehabi Lucy Chan Suhaini Kadiman Anita Alias Wan Nasrudin Ismail Mohd Ali T. Ismail Tan Tien Meng Khoo Saedah Binti Ali Mat Ariffin Saman Ahmad Shaltut Cheng Cheng Tan Cow Yen Yong Michael Bailey | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 13 | Preface显示文摘为“计算数学的杂志”的 2007 年 9 月期的一篇前言被介绍。 | Chan, Raymond Wai-ki Ching Ng, Michael | 2007 | Journal of Computational Mathematics2007，25，5： | 3 |
| 14 | Financial executive qualifications, financial executive turnover, and adverse SOX 404 opinions显示文摘 | Chan Li Lili Sun Michael Ettredge | 2010 | Journal of Accounting and Economics2010，，1： | 3 |
| 15 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans显示文摘 | Barbra H. Stewart O. Helen Chan Rosalind H. Lu Eric L. Reyner Heidi L. Schmid Harriet W. Hamilton Bruce A. Steinbaugh Michael D. Taylor | 1995 | Pharmaceutical Research1995，，5： | 2 |
| 16 | A MULTIPLE INTELLIGENT AGENT SYSTEM FOR CREDIT RISK PREDICTION VIA AN OPTIMIZATION OF LOCALIZED GENERALIZATION ERROR WITH DIVERSITY显示文摘公司破产每年在损失花费了十亿美元到银行。因此承认风险预言是一个银行的贷款赞同决定过程的关键部分。为信用风险预言的传统的金融模型为 describingtoday 在金融健康和一个公司的潜在的破产之间的复杂关系不再是足够的。Inthis 工作,一个多重分类器系统(在一个多重聪明的代理人系统嵌入) 被建议预言一个公司的金融健康。在我们的模型,每个单个代理人(分类器) 基于公司的仅仅偏爱的信息在信用风险的可能性上做预言。每代理人是一位专家,但是限制了知识(由特征代表了) 关于公司。所有代理人的决定一起被联合形成最后的信用风险预言。实验证明我们的模型用 benchmarking Compustat 美国公司数据集超过另外的存在方法。 | Daniel S. YEUNG Wing W. Y. NG Aki P. F. CHAN Patrick P. K. CHAN Michael FIRTH Eric C. C. TSANG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 2 |
| 17 | The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly显示文摘 | Amir A. Zeki Michael Schivo Andrew Chan Timothy E. Albertson Samuel Louie Nicola Scichilone | 2011 | Journal of Allergy2011，，： | 2 |
| 18 | Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation: Results of A Multi-Center FDG-PET/CT Feasibility Study显示文摘 | Ahmed Tawakol Zahi A. Fayad Robin Mogg Achilles Alon Michael T. Klimas Hayes Dansky Sharath S. Subramanian Amr Abdelbaky James H.F. Rudd Michael E. Farkouh Irene O. Nunes Chan R. Beals Sudha S. Shankar | 2013 | Journal of the American College of Cardiology2013，，： | 2 |
| 19 | Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis显示文摘 | Lok Yung Chan Hoi Hin Kwok Renee Wan Yi Chan Malik Joseph Sriyal Peiris Nai Ki Mak Ricky Ngok Shun Wong Michael Chi Wai Chan Patrick Ying Kit Yue | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 20 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
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