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| 1 | Liver-specific gene expression in mesenchymal stem cells is induced by liver cells显示文摘AIM: The origin of putative liver cells from distinct bone marrow stem cells, e.g. hematopoietic stem cells or multipotent adult progenitor cells was found in recent in vitro studies. Cell culture experiments revealed a key role of growth factors for the induction of liver-specific genes in stem cell cultures. We investigated the potential of rat mesenchymal stem cells (MSC) from bone marrow to differentiate into hepatocytic cells in vitro. Furthermore,we assessed the influence of cocultured liver cells on induction of liver-specific gene expression.METHODS: Mesenchymal stem cells were marked with green fluorescent protein (GFP) by retroviral gene transduction. Clonal marked MSC were either cultured under liver stimulating conditions using fibronectin-coated culture dishes and medium supplemented with SCF, HGF,EGF, and FGF-4 alone, or in presence of freshly isolated rat liver cells. Cells in cocultures were harvested and GFP+ or GFP- cells were separated using fluorescence activated cell sorting. RT-PCR analysis for the stem cell marker Thy1 and the hepatocytic markers CK-18, albumin, CK-19,and AFP was performed in the different cell populations.RESULTS: Under the specified culture conditions, rat MSC cocultured with liver cells expressed albumin-, CK-18,CK-19, and AFP-RNA over 3 weeks, whereas MSC cultured alone did not show liver specific gene expression.CONCLUSION: The results indicate that (1) rat MSC from bone marrow can differentiate towards hepatocytic lineage in vitro, and (2) that the microenvironment plays a decisive role for the induction of hepatic differentiation of rMSC. | Claudia Lange Philipp Bassler Michael V. Lioznov Helge Bruns Dietrich Kluth Axel R. Zander Henning C. Fiegel | 2005 | World Journal of Gastroenterology2005，11，29： | 31 |
| 2 | Prognostic value of CA 19-9, CEA, CRP, LDH and bilirubin levels in locally advanced and metastatic pancreatic cancer: results from a multicenter, pooled analysis of patients receiving palliative chemotherapy显示文摘 | Michael Haas Volker Heinemann Frank Kullmann Rüdiger P. Laubender Christina Klose Christiane J. Bruns Stefan Holdenrieder Dominik P. Modest Christoph Schulz Stefan Boeck | 2013 | Journal of Cancer Research and Clinical Oncology2013，，4： | 4 |
| 3 | Analysis of muscle fiber conduction velocity enables reliable detection of surface EMG crosstalk during detection of nociceptive withdrawal reflexes显示文摘 | Michael Brun Jensen Jos Alberto Biurrun Manresa Ken Steffen Frahm | 2013 | BMC Neuroscience2013，14，： | 1 |
| 4 | Tungsten Oxide Buffer Layers Fabricated in an Inert Sol‐Gel Process at Room‐Temperature for Blue Organic Light‐Emitting Diodes显示文摘 | Stefan H?fle Michael Bruns Stefan Str?ssle Claus Feldmann Uli Lemmer Alexander Colsmann | 2013 | Adv Mater2013，，30： | 1 |
| 5 | Bendamustine in patients with relapsed or refractory multiple myeloma显示文摘 | Michael M Bruns I Bolke E | 2010 | Eur J Med Res2010，15，1： | 1 |
| 6 | Bendamustine in patients with relapsed or refractory multiple myeloma 显示文摘 | MICHAELL M BRUNS I BOLKE E | 2010 | Eur J Med Res2010，15，： | 1 |
| 7 | Analysis of muscle fiber conduction velocity en ablesreliable detection of surface EMG crosstalk during detection ofnociceptive withdrawal reflexes显示文摘 | Michael Brun Jensen Jos Alberto Biurrun Manresa Ken Stef fenFrahm | 2013 | BMC Neuroscience2013，14，5： | 1 |
| 8 | Medical and surgical therapy of inflammatory bowel disease in the elderly — Prospects and complications显示文摘 | Andreas Stallmach Stefan Hagel Akram Gharbi Utz Settmacher Michael Hartmann Carsten Schmidt Tony Bruns | 2011 | Journal of Crohn’s and Colitis2011，，： | 1 |
| 9 | Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress显示文摘 | Gereon Poschmann Michael Grzendowski Anja Stefanski Eva Bruns Helmut Erich Meyer Kai Stühler | 2014 | BBA - Proteins and Proteomics2014，，： | 1 |
| 10 | Determinants of Intracerebral Hemorrhage Growth: An Exploratory Analysis显示文摘 | Joseph P. Broderick Michael N. Diringer Michael D. Hill Nikolai C. Brun Stephan A. Mayer Thorsten Steiner Brett E. Skolnick Stephen M. Davis | 2007 | Stroke2007，，3： | 1 |
| 11 | Nanophase-separated amphiphilic conetworks as versatilematrixes for optical chemical and biochemical sensors显示文摘 | Michael Hanko Nico Bruns Sara Rentmeister | 2006 | Anal Chem2006，78，： | 1 |
| 12 | Comparative Clinical Outcomes of Thymectomy for Myasthenia Gravis Performed by Extended Transsternal and Minimally Invasive Approaches显示文摘 | Dan M. Meyer Morley A. Herbert Nasin C. Sobhani Paul Tavakolian Andrea Duncan Michelle Bruns Kevin Korngut Janet Williams Syma L. Prince L. Huber Gil I. Wolfe Michael J. Mack | 2009 | The Annals of Thoracic Surgery2009，，2： | 1 |
| 13 | Can a Subset of Intracerebral Hemorrhage Patients Benefit From Hemostatic Therapy With Recombinant Activated Factor VII?显示文摘 | Stephan A. Mayer Stephen M. Davis Brett E. Skolnick Nikolai C. Brun Kamilla Begtrup Joseph P. Broderick Michael N. Diringer Thorsten Steiner | 2009 | Stroke2009，，3： | 1 |
| 14 | Low power CO2 NDIR sensing using a micro-bolometer detector and a micro hotplate IR-source 显示文摘 | Pierre Barritault Michael Brun Olivier Lartigue | 2013 | Sensors and Actuators B: Chemical2013，182，6： | 1 |
| 15 | Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner显示文摘AIM To investigate the role of interleukin-19(IL-19) in a murine model of female-dominant heart failure(HF).METHODS Expression of one copy of a phosphorylation-deficient cyclic adenosine monophosphate response-element binding protein(dn CREB) causes HF, with accelerated morbidity and mortality in female mice compared to males. We assessed expression of IL-19, its receptor isoforms IL-20 R α/β, and downstream IL-19 signaling in this model of female-dominant HF. To test the hypothesis that IL-19 is cardioprotective in dn CREB-mediated HF, we generated a novel double transgenic(DTG) mouse of dn CREB and IL-19 knockout and assessed cardiac morbidity by echocardiography and survival of male and female mice.RESULTS IL-19 is expressed in the murine heart with decreased expression in dn CREB female compared to male mice. Further, the relative expression of the two IL-19 receptor isoforms manifests differently in the heart by sex and by disease. Male DTG mice had accelerated mortality and cardiac morbidity compared to dn CREB males, while female DTG mice showed no additional detriment, supporting the hypothesis that IL-19 is cardioprotective in this model. CONCLUSION Together, these data suggest IL-19 is an important cytokine mediating sex-specific cardiac(dys) function. Ongoing investigations will elucidate the mechanism(s) of sex-specific IL-19 mediated cardiac remodeling. | Danielle R Bruns Alexander R Ghincea Christian V Ghincea Yasu-Taka Azuma Peter A Watson Michael V Autieri Lori A Walker | 2017 | World Journal of Cardiology2017，9，8： | 0 |
| 16 | Imaged guided surgery during arteriovenous malformation of gastrointestinal stromal tumor using hyperspectral and indocyanine green visualization techniques:A case report显示文摘BACKGROUND This case report demonstrates the simultaneous development of a gastrointestinal stromal tumour(GIST)with arteriovenous malformations(AVMs)within the jejunal mesentery.A 74-year-old male presented to the department of surgery at our institution with a one-month history of abdominal pain.Contrast-enhanced computed tomography revealed an AVM.During exploratory laparotomy,hyperspectral imaging(HSI)and indocyanine green(ICG)fluorescence were used to evaluate the extent of the tumour and determine the resection margins.Intraoperative imaging confirmed AVM,while histopathological evaluation showed an epithelioid,partially spindle cell GIST.CASE SUMMARY This is the first case reporting the use of HSI and ICG to image GIST intermingled with an AVM.The resection margins were planned using intraoperative analysis of additional optical data.Image-guided surgery enhances the clinician’s knowledge of tissue composition and facilitates tissue differentiation.CONCLUSION Since image-guided surgery is safe,this procedure should increase in popularity among the next generation of surgeons as it is associated with better postoperative outcomes. | Tristan Wagner Onur Mustafov Marielle Hummels Anders Grabenkamp Michael N Thomas Lars Mortimer Schiffmann Christiane J Bruns Dirk L Stippel Roger Wahba | 2023 | World Journal of Clinical Cases2023，11，23： | 0 |
| 17 | High coercivity in large exchange-bias Co/CoO-MgO nano-granular films显示文摘We present a detailed study on the magnetic coercivity of Co/CoO-MgO core-shell systems, which exhibits a large exchange bias due to an increase of the uncompensated spin density at the interface between the CoO shell and the metallic Co core by replacing Co by Mg within the CoO shell. We find a large magnetic coercivity of 7120 Oe around the electrical percolation threshold of the Co/CoO core/shell particles, while samples with a smaller or larger Co metal volume fraction show a considerably smaller coercivity. Thus, this study may lead to a route to improving the magnetic properties of artificial magnetic material in view of potential applications. | 葛传楠 万贤纲 Eric Pellegrin 胡志伟 Wen-I Liang Michael Bruns 邹文琴 都有为 | 2015 | Chinese Physics B2015，24，3： | 0 |
| 18 | Clinical use of augmented reality,mixed reality,three-dimensionalnavigation and artificial intelligence in liver surgery显示文摘A precise knowledge of intra-parenchymal vascular and biliary architecture and the location of lesions in relation to the complex anatomy is indispensable to perform liver surgery.Therefore,virtual three-dimensional(3D)-reconstruction models from computed tomography/magnetic resonance imaging scans of the liver might be helpful for visualization.Augmented reality,mixed reality and 3Dnavigation could transfer such 3D-image data directly into the operation theater to support the surgeon.This review examines the literature about the clinical and intraoperative use of these image guidance techniques in liver surgery and provides the reader with the opportunity to learn about these techniques.Augmented reality and mixed reality have been shown to be feasible for the use in open and minimally invasive liver surgery.3D-navigation facilitated targeting of intraparenchymal lesions.The existing data is limited to small cohorts and description about technical details e.g.,accordance between the virtual 3D-model and the real liver anatomy.Randomized controlled trials regarding clinical data or oncological outcome are not available.Up to now there is no intraoperative application of artificial intelligence in liver surgery.The usability of all these sophisticated image guidance tools has still not reached the grade of immersion which would be necessary for a widespread use in the daily surgical routine.Although there are many challenges,augmented reality,mixed reality,3Dnavigation and artificial intelligence are emerging fields in hepato-biliary surgery. | Roger Wahba Michael N Thomas Alexander C Bunck Christiane J Bruns Dirk L Stippel | 2021 | Artificial Intelligence in Gastroenterology2021，2，4： | 0 |
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