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| 1 | Aerogravity-assist maneuvers:coupled trajectory and vehicle shape optimization显示文摘 | Roberto A Michèle L Ryan P S | | 0，，05： | 1 |
| 2 | Identification of staphylococcus species by 16S-23S rDNA intergenic spacer PCR analysis 显示文摘 | Marcos M Hélène M Michèle B | 1998 | Int J Sys Bacteriol1998，48，： | 1 |
| 3 | Acute hepatitis C during the third trimester of pregnancy显示文摘 | Florent Gonzalez Michèle-Ange Medam-Djomo Damien Lucidarme Ali Khalil Anne Decoster Denis Houze de L’Aulnoit Bernard Filoche | 2006 | Gastroenterologie Clinique et Biologique2006，，5： | 1 |
| 4 | Process conditions for preparing well-defined nano- and microparticles as delivery systems of alkyl gallates显示文摘Dextran-covered poly(D,L-lactide) (PLA) nano-and microparticles were prepared using an emulsion/solvent evaporation (or diffusion) process for the encapsulation of alkyl gallates (AGs).In the first step,a solution of PLA and AG in ethyl acetate was emulsified to give an aqueous phase containing a hydrophobically modified dextran,which acted as a stabilizer.The second step involved solvent evaporation or diffusion.The emulsification conditions were varied,which allowed for the preparation of nanoand microparticle suspensions covering a wide range of surface-average particle diameters from 0.1 μm (sonication) to 500 μm (stirring with a magnetic bar),with narrow and reproducible size distributions.Continuous microfluidic emulsification in a flow-focusing system led to well-defined microparticles,in the 10-50 μm range.Particles loaded with octyl gallate (OG) and nonyl gallate (NG) were obtained using the three processes,and we showed that the encapsulation efficiency of OG and NG varied significantly depending on the emulsification process.The effect of particle size on the mechanism of in vitro release of encapsulated AGs was investigated.The kinetics of release were controlled either by Fickian diffusion within the solid core or swelling and hydrolytic degradation of the PLA matrix,depending on the pH of the external medium. | Asma Chebil Denis Funfschilling Jean-Luc Six Cécile Nouvel Alain Durand Michèle Léonard | 2019 | Particuology2019，17，3： | 1 |
| 5 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 6 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 1 |
| 7 | Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis显示文摘 | Frédérique Maire Anne Couvelard Pascal Hammel Philippe Ponsot Laurent Palazzo Alain Aubert Claude Degott Alain Dancour Michèle Felce-Dachez Dermot O’Toole Philippe Lévy Philippe Ruszniewski | 2003 | Gastrointestinal Endoscopy2003，，5： | 1 |
| 8 | Intraductal papillary mucinous tumors of the pancreas: the preoperative value of cytologic and histopathologic diagnosis显示文摘 | Frédérique Maire Anne Couvelard Pascal Hammel Philippe Ponsot Laurent Palazzo Alain Aubert Claude Degott Alain Dancour Michèle Felce-Dachez Dermot O'Toole Philippe Lévy Philippe Ruszniewski | 2003 | Gastrointestinal Endoscopy2003，，5： | 1 |
| 9 | Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy显示文摘 | Zhao Min Célérier Isabelle Bousquet Elodie Jeanny Jean-Claude Jonet Laurent Savoldelli Michèle Offret Olivier Curan Antoine Farman Nicolette Jaisser Frédéric Behar-Cohen Francine | 2012 | EN2012，，7： | 1 |
| 10 | Comparative hybridization of an array of 21 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas显示文摘 | Michèl Schummer WaiLap V Ng Roger E Bumgarner Peter S Nelson Bernhard Schummer David W Bednarski Laurie Hassell Rae Lynn Baldwin Beth Y Karlan Leroy Hood | 1999 | Gene1999，，2： | 1 |
| 11 | LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood显示文摘 | CarolineMichot LaurenceHubert MichèleBrivet LindaDe Meirleir VassiliValayannopoulos WolfgangMüller‐Felber RameshVenkateswaran HélèneOgier IsabelleDesguerre CéciliaAltuzarra ElizabethThompson MartinSmitka AngelaHuebner MarieHusson RitaHorvath PatrickChinne | 2010 | Hum. Mutat2010，，7： | 1 |
| 12 | Comparative hybridization of an array of 21 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas显示文摘 | Michèl Schummer WaiLap V Ng Roger E Bumgarner Peter S Nelson Bernhard Schummer David W Bednarski Laurie Hassell Rae Lynn Baldwin Beth Y Karlan Leroy Hood | 1999 | Gene1999，，2： | 1 |
| 13 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 2 |
| 14 | Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 1 |
| 15 | HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study显示文摘 | Raph L Hamers Carole L Wallis Cissy Kityo Margaret Siwale Kishor Mandaliya Francesca Conradie Mariette E Botes Maureen Wellington Akin Osibogun Kim C E Sigaloff Immaculate Nankya Rob Schuurman Ferdinand W Wit Wendy S Stevens Michèle van Vugt Tobias F Rink | 2011 | The Lancet Infectious Diseases2011，，10： | 1 |
| 16 | <ce:link locator='fx1'/> <ce:link locator='fx2'/> Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis显示文摘 | Rami Moucari Tarik Asselah Dominique Cazals–Hatem Hélène Voitot Nathalie Boyer Marie–Pierre Ripault Rodolphe Sobesky Michèle Martinot–Peignoux Sarah Maylin Marie–Hélène Nicolas–Chanoine Valérie Paradis Michel Vidaud Dominique Valla Pierre Bedossa Patrick | 2008 | Gastroenterology2008，，2： | 1 |
| 17 | 手术后间断使用或持续长期使用斯达汀对大血管手术患者心脏转归的影响显示文摘背景斯达汀可降低非手术人群的心脏并发症,手术患者也可能受益。本研究旨在观察与间断使用者比较,大血管手术后持续使用斯达汀患者的心脏转归有无差异。方法对前瞻性收集的肾下型主动脉手术患者的资料进行研究,分析斯达汀治疗和围手术期心脏并发症的相关性。2001年1月至2003年12月,临床尚无围手术期持续使用斯达汀的指南(间断使用组,n=491)。2004年1月制定指南推荐手术后尽早开始斯达汀持续治疗(持续使用组,n=178)。分析心肌坏死(定义为肌钙蛋白Ⅰ增高〉99百分位数或0.2ng/ml)的发生情况。组内(倾向性评分)和组间(Lee评分)均进行风险调整。结果 间断使用组和持续使用组手术后重新使用斯达汀治疗的时间间隔中位数分别为4天和1天(P〈0.001)。采用倾向性评分对手术前斯达汀治疗的可能性进行匹配,结果显示,手术后早期使用斯达汀和未早期使用(持续使用组与间断使用组)对手术后心肌坏死风险的比值比(OR)分别为0.38和2.1(相对危险度降低5.4倍,95%可信区间:1.2—25.3,P〈0.001)。经Lee评分调整后OR在持续使用组为0.38,间断使用组为2.1(相对危险度降低5.5倍,95%可信区间:1.2~26.0,P〈0.001)。手术后斯达汀停药(〉4天)是手术后心肌坏死的独立预测因素(OR2.9,95%可信区间:1.6—5.5)。结论大血管手术后间断使用斯达汀与手术后心脏风险增高相关,建议大血管手术后尽早使用斯达汀。 | Yannick Le Manach Gilles Godet Pierre Coriat Claire Martinon Michèle Bertrand Marie-Hélène Fléron Bruno Riou 康茵(译) 王庆(译) 赵国栋(校) | 2008 | 麻醉与镇痛2008，4，4： | 0 |
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