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| 1 | Immune checkpoint inhibitor-induced colitis:A comprehensive review显示文摘Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1.ICIs have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. | Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra Mark C Mattar | 2019 | World Journal of Clinical Cases2019，7，4： | 14 |
| 2 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 3 | Occult gastric cancer presenting as hypoxia from pulmonary tumor thrombotic microangiopathy显示文摘 | Mandaliya R Farhat S Uprety D | 2014 | J Gastric Cancer2014，14，2： | 1 |
| 4 | Small cell lung cancer presenting as severe thrombocytopenia and re- fractory hypokalemia 显示文摘 | Mandaliya R Hughes L Auerbach H | 2014 | Case Rep Oncol Med2014，2014，87： | 1 |
| 5 | Two stage reconstruc- tion protocol in management of hing-energy proximal tibia fractures ( sschatzker, type IV-VI ) 显示文摘 | Maru N Mandaliya D Parmar R | 2012 | Journal of Evolution of Medical and Dental Sciences2012，4，10： | 1 |
| 6 | A novel approach to correct retracted nipples 显示文摘 | Rathi S Mandaliya J | 2011 | Indian Pediatr2011，48，3： | 1 |
| 7 | Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation显示文摘 | Quaghebeur A Mutunga L Mwanyumba F Mandaliya K Verhofstede C Temmerman M | 2004 | AIDS2004，18，： | 1 |
| 8 | HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study显示文摘 | Raph L Hamers Carole L Wallis Cissy Kityo Margaret Siwale Kishor Mandaliya Francesca Conradie Mariette E Botes Maureen Wellington Akin Osibogun Kim C E Sigaloff Immaculate Nankya Rob Schuurman Ferdinand W Wit Wendy S Stevens Michèle van Vugt Tobias F Rink | 2011 | The Lancet Infectious Diseases2011，，10： | 1 |
| 9 | Treatment of cervieitis is associated with decreased cervical shedding of HIV-1 显示文摘 | Mcclelland RS Wang CC Mandaliya K | 2001 | AIDS2001，15，1： | 1 |
| 10 | Monitoring inflammatory bowel disease during pregnancy:Current literature and future challenges显示文摘Inflammatory bowel disease has a high prevalence in women of childbearing age and can have a significant impact on pregnancy, from conceiving to carrying the pregnancy. Active disease during pregnancy is known to have negative effects on pregnancy outcomes; therefore, careful monitoring during this period is an important but challenging aspect of care and is crucial as it affects important management decisions. Recent data seems to suggest that endoscopy is a relatively safe procedure during all trimesters of pregnancy. Serum biomarkers such as C-reactive protein and fecal calprotectin are helpful non-invasive markers, but have shown conflicting results for correlation with disease activity in some initial studies. Further work is necessary to establish standard of care monitoring during pregnancy. | Tenzin Choden Rohan Mandaliya Aline Charabaty Mark C Mattar | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，1： | 0 |
| 11 | Role of colonoscopy in diagnosis of capecitabine associated ileitis:Two case reports显示文摘BACKGROUND Capecitabine is considered a first line agent in adjuvant therapy for breast and colorectal cancer. However,cases of severe diarrhea have been reported with increasing frequency in recent years. When diarrhea is severe and prolonged,capecitabine associated ileitis should be considered as a possible etiology.CASE SUMMARY Herein,we present two cases of capecitabine ileitis,specifically involving the terminal ileum and ascending colon. We will demonstrate the disease course and treatment modalities applied to alleviate this condition,as well as discuss the merits of using colonoscopy to aid in diagnosis.CONCLUSION Ultimately our cases demonstrate that symptomatic management with traditional anti-diarrheal medications is largely ineffective. Prompt recognition and discontinuation of capecitabine is an imperative step in proper management of this condition and colonoscopy with biopsy can be helpful when the diagnosis is unclear. | Alexander E Dao Angela Hsu Ahmad Nakshabandi Rohan Mandaliya Sandeep Nadella Anita Sivaraman Mark Mattar Aline Charabaty | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 0 |
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