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您的检索式：作者名="Mengqing Yan"
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| 1 | Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4显示文摘Free fatty acids(FFAs)play important roles in cardiovascular disease.Studies have shown that it is an important way for FAs to exert biological effects through their own receptors besides directly participating biochemical reaction in body.Free fatty acid receptor 2(FFA2)can be activated by short-chain FAs and is involved in inflammatory reactions and lipid accumulation.Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy,we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy.This paper showed that FFA2 expression significantly increased in cardiac hypertrophy in vivo and in vitro.FFA2 agonist 4-CMTB or TUG-1375 promoted the expression of the hypertrophy markers ANF and BNP and increased cell surface area in vitro,which was further strengthened by FFA2 overexpression,suggesting that FFA2 might contribute to cardiomyocyte hypertrophy.Furthermore,4-CMTB treatment or FFA2 overexpression combined with 4-CMTB treatment elevated the phosphorylation and transcriptional activity of GATA4 and STAT3,which were inhibited by an ERK1/2 inhibitor,and GATA4 and STAT3 knockdown inhibited the elevation of hypertrophy biomarkers in cardiomyocytes treated with 4-CMTB.Taken together,these data indicate that FFA2 can enhance cardiomyocyte hypertrophy by activating STAT3 and GATA4 via ERK1/2,providing a potential new target for therapy. | Hui Gao Kunming Tian Xiaojun Feng Mengqing Yan Chen Gao Yisheng Jiang Chenhao Zhu Huzhe Zhu Xueping Liu Yingfu Peng | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 2 | Application of Temporary Technology for Soil and Water Conservation in Crop Protection显示文摘The increasing of highway engineering construction makes soil and water loss surrounding highway and also influences the growth of crops around.To control soil and water loss,new engineering measures are put forward to protect soil and water and prevent crops from being damaged. | Yu Sihang Yan Mengqing Zheng Xian | 2015 | Meteorological and Environmental Research2015，6，4： | 0 |
| 3 | Enhanced interphasial stability of hard carbon for sodium-ion battery via film-forming electrolyte additive显示文摘Although the operating mechanism of sodium-ion battery(SIB)resembles that of lithium-ion battery,common film-forming additive for lithium-ion battery does not play its role in SIB.Therefore,it is essential to tailor new additives for SIB.Hard carbon(HC),as the most used anode material of SIB,has the disadvantage of interphasial instability,especially under the condition of long-term cycling.The incessant accumulation of electrolyte decomposition products leads to a significant increase in interphasial impedance and a sharp decline in discharge capacity.In this work,N-phenyl-bis(trifluoromethanesulfonimide)(PTFSI)was proposed as a novel film-forming electrolyte additive,which effectively enhances the long-term cycling performance for HC anode in SIB.The passivation film generated from the preferential reduction of PTFSI improves the capacity retention of HC/Na half-cell from 0%to 68%after 500 cycles.Profoundly,the enhanced interphasial stability of HC anode results in a 52%increase in capacity retention of HC/Na_(3)V_(2)(PO_(4))_(3)full-cells after 100 cycles. | Wenguang Zhang Fanghong Zeng Huijuan Huang Yan Yu Mengqing Xu Lidan Xing Weishan Li | 2023 | Nano Research2023，16，3： | 0 |
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