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| 1 | The complex genetics in autism spectrum disorders显示文摘Autism spectrum disorders(ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants(CNVs), linkage regions, and micro RNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis. | HUA Rui WEI MengPing ZHANG Chen | 2015 | Science China(Life Sciences)2015，58，10： | 10 |
| 2 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
| 3 | Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap显示文摘树枝状的脊骨是是在哺乳动物的大脑的有刺激性的 synaptic 输入的主要地点的充满肌动朊的膜伸出,并且他们的词法粘性为学习和记忆提供结构的基础。这里,我们报导与在在 presynaptic 终端的调停 clathrin 的 synaptic 泡 endocytosis 的一个生长得很好的角色, endophilin A1 也本地化到树枝状的脊骨并且为脊骨形态发生,触处形成和 synaptic 功能被要求。我们识别 p140Cap,细胞骨架重组的一个管理者, endophilin A1 的一个下游的受动器并且证明他们的相互作用的那混乱损害脊骨形成和成熟。而且,我们表明那 endophilin A1 或 p140Cap 击倒损害脊骨稳定和 synaptic 功能。我们进一步证明 endophilin A1 调整 p140Cap 和它的下游的受动器的分发,在树枝状的脊骨的 F-actin-binding 蛋白质 cortactin 以及 F 肌动朊丰富。一起,这些结果通过 p140Cap 的规定在脊骨形态发生,稳定和 synaptic 功能揭示 postsynaptic endophilin A1 的新奇功能。 | Yanrui Yang Mengping Wei Ying Xiong Xiangyang Du Shaoxia Zhu Lin Yang Chen Zhang Jia-Jia Liu | 2015 | Cell Research2015，25，4： | 2 |
| 4 | Studies on forest ecosystem physiology: marginal water-use efficiency of a tropical, seasonal, evergreen forest in Thailand显示文摘Marginal water-use efficiency plays a critical role in plant carbon–water coupling relationships.We investigated the ecosystem marginal water-use efficiency(k)of a tropical seasonal evergreen forest to(1)determine the general pattern of k across time,(2)compare different models for calculating k,and(3)address how k varies with soil water content during different seasons.There was a U-shaped diurnal pattern in k,which was higher in the early morning and late afternoon.At other times of the day,k was lower and remained constant.Ecosystem k was higher in the wet season than in the dry season.All three models successfully captured the diurnal and seasonal patterns of k but differed in the calculated absolute values.The idea that k is constant on a subdaily scale was partly supported by our study,while a constant k was only true when data from the early morning and late afternoon were not included.Theλincreases with soil water content on a seasonal scale,possibly because early morningλremained low in dry conditions when the soil water content was low. | Mengping Chen Guanze Wang Shuangxi Zhou Junfu Zhao Xiang Zhang Chunsheng He Yongjiang Zhang Liang Song Zhenghong Tan | 2019 | Journal of Forestry Research2019，30，6： | 1 |
| 5 | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture显示文摘Although common in clinical practice,bleeding after tissue puncture may cause serious outcomes,especially in arterial puncture.Herein,gelatin-tannic acid composite hydrogels with varying compositions are prepared,and their adhesive properties are further optimized in microfluidic channel-based simulated vessels for haemostasis in arterial puncture.It is revealed that the composite hydrogels on the syringe needles used for arterial puncture should possess underwater adhesion higher than 4.9 kPa and mechanical strength higher than 86.0 kPa.The needles coated with the gelatin-tannic acid composite hydrogel completely prevent blood loss after both vein and arterial puncture in different animal models.This study holds great significance for the preparation of haemostatic needles for vessel puncture,and gelatin-tannic acid hydrogel coated needles may help to prevent complications associated with arterial puncture. | Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang | 2022 | Bioactive Materials2022，7，6： | 0 |
| 6 | Noninvasive Tracking of Every Individual in Unmarked Mouse Groups Using Multi-Camera Fusion and Deep Learning显示文摘Accurate and efficient methods for identifying and tracking each animal in a group are needed to study complex behaviors and social interactions.Traditional tracking methods(e.g.,marking each animal with dye or surgically implanting microchips)can be invasive and may have an impact on the social behavior being measured.To overcome these shortcomings,video-based methods for tracking unmarked animals,such as fruit flies and zebrafish,have been developed.However,tracking individual mice in a group remains a challenging problem because of their flexible body and complicated interaction patterns.In this study,we report the development of a multi-object tracker for mice that uses the Faster region-based convolutional neural network(R-CNN)deep learning algorithm with geometric transformations in combination with multi-camera/multi-image fusion technology.The system successfully tracked every individual in groups of unmarked mice and was applied to investigate chasing behavior.The proposed system constitutes a step forward in the noninvasive tracking of individual mice engaged in social behavior. | Feng Su Yangzhen Wang Mengping Wei Chong Wang Shaoli Wang Lei Yang Jianmin Li Peijiang Yuan Dong-Gen Luo Chen Zhang | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 7 | Woman Remembers her Past by the Hualong Bridge显示文摘IN the Shapingba District in Chongqing, Sichuan Province, there is the Hualong Bridge. During World War Ⅱ, my father ran a bean curd plant near the bridge where he sold bean curd and green vegetables. My mother made the bean curd while I helped to tend the kitchen fire. This small bean curd plant witnessed the hard times that my family had undergone in the eight years of the War of Resistance Against the Japanese Aggression. Now I’m over 70 and live together with my children in Hong Kong. Although I now live a peaceful and comfortable life, I cannot forget the past—the long, unstable years by | ZHOU MENGPING CHEN SHANSHAN | 1994 | Women of China1994，，7： | 0 |
| 8 | Analysis of the distribution characteristics of enterovirus types based on environmental surveillance from 2013 to 2021 in Fujian Province, China显示文摘Environmental surveillance (ES) is a useful approach for monitoring circulating viruses, including polioviruses (PVs) and non-polio enteroviruses (NPEVs). In this study, the results of nine years of ES from 2013 to 2021 at six sampling sites in three cities in Fujian Province, China, were summarized. It showed that the sewage samples contained abundant viruses, but the positive rate was affected by different sampling sites. From the 520 samples, 431 PVs, 1,713 NPEVs, and 281 human adenoviruses (HAdVs) were isolated. PV isolates had been markedly affected following the adjustment of the immunization strategy. All but one PV isolate were Sabin-like strains without wild PVs. One isolate was vaccine-derived PV type 3 with 10 variation points in theVP1 region. After May 2016, PV type 2 was no longer detected, and PV type 3 became a superior serotype. Of 1,713 NPEVs, 24 serotypes were identified, including echovirus11 (E11), E6, coxsackievirus B3 (CVB3), CVB5, E7, and E3 were the predominant serotypes (37.65%, 20.96%, 11.50%, 8.87%, 8.23%, and 7.06%, respectively). The temporal dynamic of the six common serotypes was inconsistent. E3 was frequently isolated, but the number of isolates was low, with no obvious peaks. E6, E7, and CVB3 exhibited periodic changes with a high peak every three to four years, and E11 only had one high peak lasting four years. Summer-fall peaks of the echoviruses and spring-winter peaks of CVB were observed in the monthly distribution of virus isolation. The infectious isolates of various serotypes of different species identified from the sewage samples showed that ES is an essential part of pathogen surveillance. | Xiuhui Yang Shaojian Cai Xiaoqian Wu Yong Zhang Dong Li Yahong Chen Qianjing Chen Shuangli Zhu Dongmei Yan Wenbo Xu Hairong Zhang Zhifei Chen Suhan Zhang Yong Zhou Mengping Zhang Ningxuan Zheng Na You | 2023 | Biosafety and Health2023，5，4： | 0 |
| 9 | Improving in vivo Uranyl Removal Efficacy of a Nano-Metal Organic Framework by Interior Functionalization with 3-Hydroxy-2-pyridinone显示文摘The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites,which eventually leads to the internal uranium exposure of people,causing consequential injuries of renal failure,osteosarcoma,etc.The development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear industry.Metal organic frameworks(MOFs)already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling,uranium extraction from seawater,as well as environmental decontamination.Herein,a chromium-based nano-metal organic framework(nano-MOF)functionalized interiorly with 3,2-HOPO ligands,MIL-101-HOPO,is rationally synthesized.In vitro adsorption experiments show that MIL-101-HOPO exhibits high adsorption selectivity and fast adsorption kinetics for uranyl.The results of in vivo uranyl decorporation assays reveal that MIL-101-HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs,and is more effective than the clinically used ZnNa_(3)-DTPA.All those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents. | Mengping Chen Lang Lang Lei Chen Xiaomei Wang Cen Shi Qiwen Sun Yigong Xu Juan Diwu Shuao Wang | 2022 | Chinese Journal of Chemistry2022，40，17： | 0 |
| 10 | Sedimentological Characteristics of Sandy Gravel Beach in Kongtong Island显示文摘Hydrological characteristics such as waves, tides, currents, and meteorological features such as weather and wind, as well as geological structure were collected. Through the field trips of Kongtong Island, observations of its base rock coast, measurement of beach slope and beach gravel particle size, gravel and sandy samples was collected in the intertidal zone of west beach, east beach, and north beach of Kongtong. Particle size analysis and roundness calculation were carried out to verify whether they were consistent with the oceanographic data collected from Kongtong Island. The results showed that the north beach was mainly gravel, the west beach was a mixture of sand and gravel, and east beach was a sandy sediment. The particle sizes and roundness of different samples showed that north beach had the strongest hydrodynamic conditions, followed by the west beach, and the east beach had the weakest hydrodynamic conditions. This had a direct relationship with perennial wave direction and wind direction. Full understanding of the oceanographic characteristics of Kongtong Island is of great practical significance for the better development and utilization of Kongtong Island and the rational use of its geographic location for tourism and recreation. | ZHANG Wei LIN Mengping CHEN Yang FAN Shuimiao | 2019 | Journal of Landscape Research2019，11，6： | 0 |
| 11 | 一个转录因子的天然变异赋予水稻对稻瘟病的广谱抗性显示文摘文章简介水稻是人类重要的粮食作物,有着"水稻癌症"的稻瘟病,常年肆虐各个稻区,引起水稻大幅度减产甚至绝收,是全球粮食安全的重大隐患。一直以来,发掘和利用稻瘟病持久广谱抗性的水稻资源是水稻抗稻瘟病育种的重点和难点。 | 李伟滔 朱紫薇 Mawsheng Chern 尹俊杰 杨超 冉莉 Mengping Cheng Min He Kang Wang Jing Wang Xiaogang Zhou Xiaobo Zhu Zhixiong Chen Jichun Wang Wen Zhao Bingtian Ma Peng Qin Weilan Chen Yuping Wang Jiali Liu Wenming Wang Xianjun Wu Ping Li Jirui Wang Lihuang Zhu Shigui Li 陈学伟 | 2018 | 科学新闻2018，0，4： | 0 |
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