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| 1 | Predictors of re-hospitalization in patients with chronic heart failure显示文摘Heart failure (HF) is a chronic, progressive illness that is highly prevalent in the United States and worldwide. This morbid illness carries a very poor prognosis, and leads to frequent hospitalizations. Repeat hospitalization in HF is both largely burdensome to the patient and the healthcare system, as it is one of the most costly medical diagnoses among Medicare recipients. For years, investigators have strived to determine methods to reduce hospitalization rates of HF patients. Despite such efforts, recent reports indicate that rehospitalization rates remain persistently high, without any improvement over the past several years and thus, this topic clearly needs aggressive attention. We performed a key-word search of the literature for relevant citations. Published articles, limited to English abstracts indexed primarily in the PubMed database through the year 2011, were reviewed. This article discusses various clinical parameters, serum biomarkers, hemodynamic parameters, and psychosocial factors that have been reviewed in the literature as predictors of re-hospitalization of HF patients. With this information, ourhope is that the future holds better risk-stratification models that will allow providers to identify high-risk patients, and better customize effective interventions according to the needs of each individual HF patient. | Melody Zaya Anita Phan Ernst R Schwarz | 2012 | World Journal of Cardiology2012，4，2： | 5 |
| 2 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 3 | Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions显示文摘Point-of-care(POC) tests enable rapid results and are well established in medical practice.Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways.This review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was performed.Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included.Studies recovered were heterogeneous and therefore results are presented as a narrative review.Six diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical application.POC devices have a proven role in the diagnosis of gastrointestinal cancer.Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow.New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival. | Jeremy R Huddy Melody Z Ni Sheraz R Markar George B Hanna | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 4 | 高k材料/金属栅电极迈向大规模量产显示文摘到了45纳米技术节点,高介电常数绝缘材料和金属栅电极将被用于制造逻辑电路器件。而采用高金属功函数和能隙工程电荷陷阱的闪存也能从这些项技术中获益。 | Reza Arghavani Gary Miner Melody Agustin | 2008 | 集成电路应用2008，25，1： | 2 |
| 5 | The basal subtype of breast carcinomas may represent the group of breast tumors that could benefit from EGFR-targeted therapies显示文摘 | Kalliopi P. Siziopikou Melody Cobleigh | 2006 | The Breast2006，，1： | 2 |
| 6 | Dexamethasone Added to Mepivacaine Prolongs the Duration of Analgesia After Supraclavicular Brachial Plexus Blockade显示文摘 | Simon J. Parrington Dermot O’Donnell Vincent W.S. Chan Danielle Brown-Shreves Rajeev Subramanyam Melody Qu Richard Brull | 2010 | Regional Anesthesia and Pain Medicine2010，，5： | 2 |
| 7 | Comment on profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach显示文摘Dear Editor,We read with interest the recently published study by Trigueros et al^([1]),highlighting the financial and management conditions of femtosecond laser-assisted cataract surgery(FLACS).The authors derived a simulation to | Harrv William Roberts Melody Zhifang Ni David Phillip S. O'Brart | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 2 |
| 8 | Parameter identification for inflight detection and characterization of aircraft icing显示文摘 | Melody J W Basa T Perkins W R | 2000 | Control Engineering Practice2000，8，9： | 1 |
| 9 | Induction of basic fibroblast growth factor (bFGF)expression following focal cerebral ischemia显示文摘 | Jeanmie L Melody L | 1997 | Brain Res Mol Brain Res1997，49，： | 1 |
| 10 | Construction and optimization of a CCt9-based scFv-β-lactamnse fusion protein for ADEPT显示文摘 | Martin R Melodie E Joshua B | 2006 | PEDS2006，19，4： | 1 |
| 11 | Early postmortem biochemical factors influence tenderness and water-holding capacity of three porcine muscles 显示文摘 | MELODY JL LONERGAN SM ROWE LJ | 2004 | Anima Sci2004，82，4： | 1 |
| 12 | H parameter identification for inflight detection of aircraft icing: the time-varying case显示文摘 | Melody J W Hillbrand T Basar T | 2001 | Control Engineering Practice2001，9，12： | 1 |
| 13 | Induction of basic fibroblast growth factor (bFGF) expression following focal cerebral ischemia显示文摘 | Teng N jeannie Lee Melody Lee | 1997 | Brain Res Mol Res1997，49，12： | 1 |
| 14 | The impact of compliance with 6 hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study显示文摘 | Gao F Melody T Daniels D F | 2005 | Crit Care2005，9，6： | 1 |
| 15 | Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila显示文摘 | Eric D. Sassu Jacqueline E. McDermott Brendan J. Keys Melody Esmaeili Alex C. Keene Morris J. Birnbaum Justin R. DiAngelo | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 1 |
| 16 | 图书馆、档案馆、博物馆一体化背景下的数字保管人员能力研究显示文摘1数字保管及数字保管人员数字保存作为一个新的研究领域,涉及到计算机、数字档案馆、数字博物馆和数字图书馆等多个不同的专业。由于不同专业领域对于"存储"、"归档"、"信息"以及"数据"的解释不同,所以不同文献对这一领域的定义也千差万别。从某种程度上讲,为了克服不同学科和研究领域之间的交流障碍,一个新的术语应运而生,即数字资源保存管理(Digital Curation,下简称"数字保管"),它结合了"保管"和"数字保存"两方面的含义。 | Anna Maria Tammaro Melody Madrid Vittore Casarosa 安宁 沈晓雪 | 2015 | 四川档案2015，，1： | 1 |
| 17 | Induction of basci fibrohlast growth factor (bFGF) expression following focal cerebral ischemia 显示文摘 | Teng N Jeannie Lee Melody Lee | 1997 | Brain Res Mol Res1997，49，： | 1 |
| 18 | Use of a fluorimetric test for bovine alkaline phospatase to demonstrate under-pasteurisation of skimmed milk and cream显示文摘 | ANTIA M R MELODY H G GARETH EN D | 2004 | International Dairy Journal2004，14，： | 1 |
| 19 | Discrete-frequency and broadband reaction wheel disturbance models 显示文摘 | Melody J W | 1995 | Interoffice Memorandum1995，95，3411： | 1 |
| 20 | Comparison of Cystoscopic and histological findings in patients with Suspected interstial Cystitis显示文摘 | Denson Tomas L Griebling | 2000 | J Urol2000，164，： | 1 |
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