|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Chitosan from Syncephalastrum racemosum used as a film support for lipase immobilization显示文摘 | Amorim RVS Melo ES Carneiro-da-Cunha MG | 2003 | Bioresour Technol2003，89，1： | 1 |
| 4 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 5 | Imaging modality correlations of an odontogenic keratoeyst in the nevoid basal cell earcinoma syndrome:a family case report显示文摘 | Melo ES Kawamura JY Alves CA | 2004 | Oral Surg Oral Med OralPathol Oral Radiol Endod2004，98，2： | 1 |
| 6 | Imaging modality correlations of an odontogenic keratocyst in the nevoid basal cell carcinoma syndrome:A family case report显示文摘 | Kawamura JY Alves CA | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，2： | 1 |
| 7 | Adsorption studies of methylene blue and gentian violet on sugarcane bagasse modified with EDTA dianhydride (EDTAD) in aqueous solutions: Kinetic and equilibrium aspects显示文摘 | Karla Aparecida Guimar?es Gusm?o Leandro Vinícius Alves Gurgel Tania Márcia Sacramento Melo Laurent Frédéric Gil | 2013 | Journal of Environmental Management2013，，： | 1 |
| 8 | Imaging modality correlations of an odontogenic keratocyst in the nevoid basal cell carcinoma syndrome: A family case report 显示文摘 | Melo ES Kawamura JY Alves CA | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，2： | 1 |
| 9 | Osteomyelitis of the mandible associated with autosomal dominant osteopetrosis: a case report 显示文摘 | Albuquerque MA Melo ES Jorge WA | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，1： | 1 |
| 10 | Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [13C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test显示文摘 | Dulciene Maria Magalh?es Queiroz Mayuko Saito Gifone Aguiar Rocha Andreia Maria Camargos Rocha Fabrício Freire Melo William Checkley Lúcia Libanez Bessa C. Braga Igor Sim?es Silva Robert H. Gilman Jean E. Crabtree | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 11 | Imaging modality correla-tions of an odontogenic keratocyst in the nevoid basal cell carcino-ma syndrome:A family case report显示文摘 | Melo ES Kawamura JY Alves CA | 2004 | Oral Surg Oral Med OralPathol Oral Radiol Endod2004，98，2： | 1 |
| 12 | Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families显示文摘 | Santana A Waiswol M Arcieri ES Vanconcellos JP Barbosa de Melo M | 2009 | Mol Vis2009，15，： | 1 |
| 13 | Imaging modalily correlations of an odontogenic ke, ratocyst in the newid basal 'ell carcinoma syndrome: a family case report 显示文摘 | Melo ES Kawamura JY Alves CA el al | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，2： | 1 |
| 14 | Immune cells and oxidative stress in the endotoxin tolerance mouse model 显示文摘 | Melo ES Barbeiro HV Ariga S | 2010 | Braz JMedBiolRes2010，43，1： | 1 |
| 15 | Shortterm supervised inpatient physiotherapy exercise protocol improves cardiac autonomic function after coronary artery bypass graft surgery-a randomised controlled trial显示文摘 | Mendes RG Simōes RP De Souza Melo Costa F | | 0，，16： | 1 |
| 16 | Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [13C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test显示文摘 | Dulciene Maria Magalh?es Queiroz Mayuko Saito Gifone Aguiar Rocha Andreia Maria Camargos Rocha Fabrício Freire Melo William Checkley Lúcia Libanez Bessa C. Braga Igor Sim?es Silva Robert H. Gilman Jean E. Crabtree | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 17 | The effects of ferulic and salicylic acids on Bacillus cereus and Pseudomonas fluorescens single- and dual-species biofilms显示文摘 | Madalena Lemos Anabela Borges Joana Teodósio Paula Araujo Filipe Mergulh?o Luís Melo Manuel Sim?es | 2013 | International Biodeterioration & Biodegradation2013，，： | 1 |
| 18 | Imaging modality correlations of an odontogenic keratocyst in the nevoid basal cell carcinoma syndrome:a family case report显示文摘 | Melo ES Kawamura JY Alves CA | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，2： | 1 |
| 19 | Screening of recombinant proteins as antigens in indirect ELISA for diagnosis of bovine tuberculosis显示文摘 | Ingrid IF Souza Elaine SP Melo Carlos AN Ramos Thaís A Farias Ana Luiza AR Osório Klaudia SG Jorge Carlos ES Vidal Altino S Silva Márcio R Silva Aiesca O Pellegrin Flábio R Araújo | 2012 | SpringerPlus2012，，1： | 1 |
| 20 | Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol显示文摘 | Guimares AG Oliveira GF Melo MS Cavalcanti SC Antoniolli AR Bonjardim LR Silva FA Santos JP Rocha RF Moreira JC Araújo AA Gelain DP Quintans-Júnior LJ | 2010 | Basic Clin Pharmacol Toxicol2010，107，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员