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| 1 | Monitoring of frozen soil hydrology in macro-scale in the Qinghai-Xizang Plateau显示文摘Monitoring of frozen soil hydrology in macro-scale was performed by Chinese and Japanese scientists from 1997 to 1998. Quality measured data were obtained. Measured data on soil moisture and temperature are preliminarily analyzed. Based on profiles of soil temperature and moisture in individual measured sites, intra-annual freezing and melting process of soil is discussed. Maximum frozen and thawed depths and frozen days in various depths are estimated. The work emphasized the spatial distribution on soil temperature and moisture in macro-scale and the effect of topography on conditions of soil water and heat. | Yongjian Ding Baisheng Ye Shiying Liu Yongping Shen Shaoling Wang Meixie Yang | 2000 | Chinese Science Bulletin2000，45，12： | 13 |
| 2 | 患者来源的类器官:一种有前景的个体化癌症治疗模式显示文摘Cancer has remained one of the biggest challenges for human health during the past few decades despite major advances in medicine[1].Poor prognosis of cancer is mainly caused by a lack of effective treatment.Moreover,many patients cannot receive appropriate treatment despite early diagnosis.High heterogeneity is a tumor characteristic and different types of cancer usually vary in clinical features and tumorigenic mechanisms,which results in different responses to drugs[2].How to predict accurately the patient’s response to drugs and choose personalized treatment is one of themain concerns of doctors. | Huayu Yang Lejia Sun Meixi Liu Yilei Mao | 2018 | Gastroenterology Report2018，6，4： | 1 |
| 3 | Oxygen-vacancy-related high-temperature dielectric relaxation and electrical conduction in 0.95K 0.5 Na 0.5 NbO 3 –0.05BaZrO 3 ceramic显示文摘 | Laijun Liu Yanmin Huang Yunhua Li Meixie Wu Liang Fang Changzheng Hu Yanzhong Wang | 2011 | Physica B: Physics of Condensed Matter2011，，1： | 1 |
| 4 | The application of FAPI-targeted theranostics in pancreatic cancer:a narrative review显示文摘Pancreatic cancer is one of the most lethal malignancies in the world.Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor progression.Fibroblast activation protein that is expressed in specific subtypes of cancer-associated fibroblasts promotes tumor growth and is related to poor survival.Recent researches have preliminarily demonstrated a promising potential of radiopharmaceuticals targeting fibroblast activation protein in diagnosis and therapy of pancreatic cancer.This article comprehensively reviews the current development and clinical translation of fibroblast activation protein inhibitor-targeting radiopharmaceuticals in pancreatic cancer and provides significant perspectives for future investigations. | Meixi Liu Marcus Hacker Li Huo Xiang Li | 2022 | Journal of Pancreatology2022，5，2： | 0 |
| 5 | Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure显示文摘Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltransferase-like protein 13(Mettl13)has been shown to regulate protein translation efficiency by acting as a protein lysine methyltransferase,but its role in cardiac pathology remains unexplored.This study aims to characterize the roles and mechanisms of Mettl13 in cardiac contractile function and HF.We found that Mettl13 was downregulated in the failing hearts of mice post-myocardial infarction(MI)and in a cellular model of oxidative stress.Cardiomyocyte-specific overexpression of Mettl13 mediated by AAV9-Mettl13 attenuated cardiac contractile dysfunction and fibrosis in response to MI,while silencing of Mettl13 impaired cardiac function in normal mice.Moreover,Mettl13 overexpression abrogated the reduction in cell shortening,Ca^(2+)transient amplitude and SERCA2a protein levels in the cardiomyocytes of adult mice with MI.Conversely,knockdown of Mettl13 impaired the contractility of cardiomyocytes,and decreased Ca^(2+)transient amplitude and SERCA2a protein expression in vivo and in vitro.Mechanistically,Mettl13 impaired the stability of c-Cbl by inducing lysine methylation of c-Cbl,which in turn inhibited ubiquitination-dependent degradation of SERCA2a.Furthermore,the inhibitory effects of knocking down Mettl13 on SERCA2a protein expression and Ca^(2+)transients were partially rescued by silencing c-Cbl in H_(2)O_(2)-treated cardiomyocytes.In conclusion,our study uncovers a novel mechanism that involves the Mettl13/c-Cbl/SERCA2a axis in regulating cardiac contractile function and remodeling,and identifies Mettl13 as a novel therapeutic target for ischemic HF. | Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang Weijie Du | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 6 | Altered expression profile of long non-coding RNAs during heart aging in mice显示文摘Objective:Long noncoding RNAs(lncRNAs)play an important role in regulating the occurrence and development of cardiovascular diseases.However,the role of lncRNAs in heart aging remains poorly understood.The objective of this study was to identify differentially expressed lncRNAs in the heart of aging mice and elucidate the relevant regulatory pathways of cardiac aging.Materials and methods:Echocardiography was used to detect the cardiac function of 18-months(aged)and 3-months(young)old C57BL/6 mice.Microarray analysis was performed to unravel the expression profiles of lncRNAs and mRNAs,and qRT-PCR to verify the highly dysregulated lncRNAs.Results:Our results demonstrated that the heart function in aged mice was impaired relative to young ones.Microarray results showed that 155 lncRNAs were upregulated and 37 were downregulated,and 170 mRNAs were significantly upregulated and 44 were remarkably downregulated in aging hearts.Gene ontology analysis indicated that differentially expressed genes are mainly related to immune function,cell proliferation,copper ion response,and cellular cation homeostasis.KEGG pathway analysis showed that the differentially expressed mRNAs are related to cytokine-cytokine receptor interaction,inflammatory mediator regulation of TRP channels,and the NF-kappa B signaling pathway.Conclusion:These results imply that the differentially expressed lncRNAs may regulate the development of heart aging.This study provides a new perspective on the potential effects and mechanisms of lncRNAs in heart aging. | Xiuxiu Wang Bingjie Hua Meixi Yu Shenzhen Liu Wenya Ma Fengzhi Ding Qi Huang Lai Zhang Chongwei Bi Ye Yuan Mengyu Jin Tianyi Liu Ying Yu Benzhi Cai Baofeng Yang | 2022 | Frigid Zone Medicine2022，2，2： | 0 |
| 7 | Perspective of molecular imaging and peptide receptor radionuclide therapy in pancreatic neuroendocrine tumors:where do we stand?显示文摘The clinical use of nuclear medicine imaging and therapy in pancreatic neuroendocrine tumors has been greatly strengthened since the approval of ^(68)Ga-DOTATATE and ^(177)Lu-DOTATATE.However,many aspects are still under discussion.In this 2-part article,we aim to collect and discuss current evidence of molecular imaging and peptide receptor radionuclide therapy(PRRT)in pancreatic neuroendocrine tumor.In the first part,we will address some critical aspects of ^(68)Ga-SSAs imaging,including diagnostic efficacy,recurrence detection and follow-up,patient selection for PRRT,and pitfalls in image interpretation.Besides,we will also briefly discuss the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography,special imaging strategy in regard to insulinoma,and the status of radiolabeled somatostatin receptor antagonist.In the second part,we aim to review the current evidence of PRRT in pancreatic neuroendocrine tumor,focusing on efficacy and safety in particular.We will also introduce the recent development of PRRT,including PRRT in high-grade neuroendocrine neoplasms,retreatment PRRT,upfront PRRT,PRRT in the setting of neoadjuvant therapy and conversion therapy,combination therapies with PRRT,PRRT withαradionuclides,and PRRT with antagonists. | Wenjia Zhu Meixi Liu Li Huo | 2023 | Journal of Pancreatology2023，6，4： | 0 |
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