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| 1 | γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats显示文摘 | Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping | 2014 | Chinese Medical Journal2014，，5： | 12 |
| 2 | Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats显示文摘Status epilepticus(SE) is a life-threatening neurological emergency associated with a high mortality rate. The serotonin 1A(5-HT1A) receptor is a possible target for the treatment of SE, but its role in animal models and the precise area of brain involved remain controversial. The hippocampus is a candidate site due to its key role in the development of SE and the existence of a high density of 5-HT1A receptors. Therefore, we investigated the effects of subcutaneous and intrahippocampal activation of 5-HT1A receptors in lithium-pilocarpine-induced SE, and tested whether the hippocampus is a true effector site. We developed SE in male Sprague-Dawley rats by giving lithium chloride(LiCl; 3 meq/kg, i.p.) 22–24 h prior to pilocarpine(25 mg/kg, i.p.), and found that 8-OH-DPAT, a 5-HT1A receptor agonist administered subcutaneously(s.c.) at 0.5 or 1.0 mg/kg 1 h before pilocarpine injection increased the latency to the first epileptiform spikes, the electrographic SE, and the behavioral generalized seizures(GS), while reducing the total EEG seizure time(P <0.01). The duration of GS was shortened only by 1.0 mg/kg 8-OH-DPAT s.c.(P <0.05). All these effects were inhibited by combined administration of WAY-100635(1.0 mg/kg, s.c.)(P <0.05), an antagonist of the 5-HT1A receptor, but WAY-100635 alone and low doses of 8-OHDPAT(0.01 and 0.1 mg/kg) did not alter seizure activity. Furthermore, intrahippocampal 8-OH-DPAT only shortened the GS duration(P <0.05). These findings imply that the 5-HT1A receptor is a promisingtherapeutic target against the generation and propagation of SE, and hippocampal receptors are involved in reducing the seizure severity. | Yi Yang Yi Guo Yifang Kuang Shan Wang Yan Jiang Yao Ding Shuang Wang Meiping Ding | 2014 | Neuroscience Bulletin2014，30，3： | 1 |
| 3 | Rapid resolution of subdural hematoma after targeted epidural blood patch treatment in patients with spontaneous intracranial hypotension显示文摘 | Wang Jin Zhang Dan Gong Xiangyang Ding Meiping | 2014 | Chinese Medical Journal2014，，11： | 1 |
| 4 | Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study显示文摘 | Yining Huang Yan Cheng Jiang Wu Yansheng Li En Xu Zhen Hong Zhengyi Li Weiwei Zhang Meiping Ding Xuguang Gao Dongsheng Fan Jinsheng Zeng Kasing Wong Chuanzhen Lu Jiangxi Xiao Chen Yao | 2008 | Lancet Neurology2008，，6： | 1 |
| 5 | Ketogenic dietary therapy in adult status epilepticus:current progress and clinical application显示文摘Status epilepticus(SE)is a common fatal neurological disease with high morbidity and mortality,Even if a large proportion of patients might be relieved from anti-seizure medications,sedatives and anesthetics,some still remain out of control.The ketogenic dietary(KD)has been proven useful in patients refractory to medications and/or who have failed to respond to surgical intervention.Recently,KD has shown beneficial therapeutic effects in children with SE,but studies in adults have rarely been reported.In this paper,we review the efficacy and utility of KD in adult SE patients and highlight its application for clinical reference and management. | Mengting Cail Wanyin Xu Yang Zheng Meiping Ding | 2022 | Acta Epileptologica2022，5，2： | 1 |
| 6 | Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study显示文摘 | Yining Huang Yan Cheng Jiang Wu Yansheng Li En Xu Zhen Hong Zhengyi Li Weiwei Zhang Meiping Ding Xuguang Gao Dongsheng Fan Jinsheng Zeng Kasing Wong Chuanzhen Lu Jiangxi Xiao Chen Yao | 2008 | Lancet Neurology2008，，6： | 1 |
| 7 | Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia显示文摘Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dysplastic lesions,rather than remote regions such as the hippocampus.Here,we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical dysplasia.We further investigated the cellular substrates leading to the epileptic hippocampus,using multiscale tools including calcium imaging,optogenetics,immunohistochemistry and electrophysiology.For the first time,we revealed the role of hippocampal somatostatin-positive interneurons in cortical dysplasia-related seizures.Somatostatin-positive were recruited during cortical dysplasia-related seizures.Interestingly,optogenetic studies suggested that somatostatin-positive interneurons paradoxically facilitated seizure generalization.By contrast,parvalbumin-positive interneurons retained an inhibitory role as in controls.Electrophysiological recordings and immunohistochemical studies revealed glutamate-mediated excitatory transmission from somatostatin-positive interneurons in the dentate gyrus.Taken together,our study reveals a novel role of excitatory somatostatin-positive neurons in the seizure network and brings new insights into the cellular basis of cortical dysplasia. | Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu Fan Fei Jiajia Fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 8 | Chinese expert recommendations on ketogenic diet therapy for super-refractory status epilepticus显示文摘Super-refractory status epilepticus(SRSE)is a serious and life-threatening neurological condition.Ketogenic diet(KD)is a diet characterized by high fat,low carbohydrate,and moderate protein.As KD shows effectiveness in controlling seizures in more than half of SRSE patients,it can be a treatment option for SRSE.Currently,KD treatment for SRSE is based on personal experience and observational evidence has been published.In the context of a lack of a validated guideline,we convened a multicenter expert panel within the China Association Against Epilepsy(CAAE)Ketogenic Diet Commission to work out the Chinese expert recommendations on KD for SRSE.We summarize and discuss the latest clinical practice of KD for SRSE in critical care settings.Recommendations are given on patient selection,the timing of KD,diet implementation,and follow-up.More research data are needed in this area to support better clinical practice. | Xin Tong Qianyun Cai Dezhi Cao Lifei Yu Dan Sun Guang Yang Jiwen Wang Hua Li Zengning Li Juan Wang Shaoping Huang Meiping Ding Fang Fang Qun Wang Rong Luo Jianxiang Liao Jiong Qin | 2022 | Acta Epileptologica2022，5，1： | 0 |
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