5篇
您的检索式：作者名="Meining Song"
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| 1 | Alectinib: a novel second generation anaplastic lymphoma kinase(ALK) inhibitor for overcoming clinically-acquired resistance显示文摘The development of inhibitors for the tyrosine anaplastic lymphoma kinase(ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in Japan. This drug has a unique chemical structure bearing a 5H-benzo[b]carbazol-11(6H)-one structural scaffold with an IC_(50) value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196 M with an IC_(50) of 1.56 nmol/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer(NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L1196 M, F1174 L, R1275 Q and C1156 Y. | Zilan Song Meining Wang Ao Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 10 |
| 2 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 3 | Study on the alteration ofchemical composition and structure parameters of modified montmorill-onite 显示文摘 | LU Xianjun CUI Xueqi SONG Meining | 2003 | Minerals Engineering2003，，16： | 1 |
| 4 | Study on the alteration of chemical composition and structure parameters of modified montmorillonite显示文摘 | Xianjun Lu Xueqi Cui Meining Song | 2003 | Minerals Engineering2003，，16： | 1 |
| 5 | Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid显示文摘Abnormal development of central nervous system(CNS)caused by neural tube defects is not only a major con tributor in the prevale nee of stillbirths and n eonatal deaths but also causes lifelong physical disability in surviving infants.Due to insufficient known investigated causes,CNS developmental abnormality has brought sever burden on health around the world.From previous results of high throughput transcriptome sequencing,we selected transcription factor Nkx2.1 as a candidate to investigate its role on brain abnormalities induced by excessive retinoic acid.The result of in situ hybridization showed that Nkx2.1 was mainly expressed in mouse brain.After the Nkx2.1 gene was sileneed,retarded proliteration and accelerated apoptosis were found in mouse Neuro-2a(N2a)cells.Furthermore,our results indicated that the main components of sonic hedgehog(Shh)signaling pathway were affected in Nkx2.7-silenced cells,implying that Nkx2.1 plays an important role in the development of mouse brain by regulating Shh signaling pathway. | Sansan Jia Li Zhang Kaili Zhang Lei Wang Ajab Khan Juan Zhang Yuqing Sun Yufei Wang Meiyan Song Yi Lyu Meining Li Xin Lu Bo Niu Zhizhen Liu Jun Xie | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
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