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| 1 | Reducing active layer thickness of polyamide composite membranes using a covalent organic framework interlayer in interfacial polymerization显示文摘Polyamide(PA)-based thin-film composite membranes exhibit enormous potential in water purification,owing to their facile fabrication,decent performance and desirable stability.However,the thick PA active layer with high transport resistance from the conventional interfacial polymerization hampers their applications.The controllable fabrication of a thin PA active layer is essential for high separation efficiency but still challenging.Herein,a covalent organic framework TpPa-1 interlayer was firstly deposited on a polyethersulfone(PES)substrate to reduce the thickness of PA active layer in interfacial polymerization.The abundant pores of TpPa-1 increase the local concentration of amine monomers by adsorbing piperazine molecules,while hydrogen bonds between hydrophilic groups of TpPa-1 and piperazine molecules slow down their diffusion rate.Arising from those synergetic effects,the PA active layer is effectively reduced from 200 nm to 120 nm.By optimizing TpPa-1 interlayer and PA active layer,the water flux of resultant membranes can reach 171.35 L·m^-2·h^-1·MPa^-1,which increased by 125.4%compared with PA/PES membranes,while the rejection rates of sodium sulfate and dyes solution remained more than 90%and 99%,respectively.Our strategy may stimulate rational design of ultrathin PA-based nanofiltration membranes with high performances. | Meidi Wang Weixiong Guo Zhongyi Jiang Fusheng Pan | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 5 |
| 2 | Construction of molecule-selective mixed matrix membranes with confined mass transfer structure显示文摘Extraordinary mass transfer phenomenon is usually found when the small molecules pass through a confined structure, whose effective size is commensurate with the mean free path of the molecules. Small changes in the confined mass transfer structure(including size, morphology and properties) will lead to significant fluctuations of the mass transfer coefficient. The mass transfer of the penetrant molecules in the dense membranes for pervaporation, gas separation and so on, is located in the scope of confined mass transfer. Incorporating nanofillers into polymer matrix to construct mixed matrix membranes(MMMs) is an effective approach to tune the confined mass transfer structure and enhance the performance of the widely used polymeric membranes. This review focuses on the construction and manipulation of the confined structure in the polymeric membranes via incorporating one-dimensional(1D), two-dimensional(2D) and three-dimensional(3D) fillers.The comparison of the MMMs for pervaporation is summarized, and the research prospective of the MMMs is provided. | Weidong Li Fusheng Pan Yimeng Song Meidi Wang Hongjian Wang Shalik Walker Hong Wu Zhongyi Jiang | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 3 |
| 3 | Lymphatic endothelial cells regulate B-cell homing to lymph nodes via a NIK-dependent mechanism显示文摘B cells home to the lymph nodes(LNs)via high endothelial venules(HEVs)under the guidance of chemokines,particularly CXCL13.However,as CXCL13 is not directly made in HEVs,the molecular mechanism mediating B-cell homing to LNs has remained unclear.We show here that nuclear factor(NF)-κB-inducing kinase(NIK),a kinase mediating activation of the noncanonical NF-κB pathway,functions in lymphatic endothelial cells(LECs)to regulate B-cell homing to LNs.LEC-conditional deletion of NIK in mice did not affect the integrity or global function of lymphatic vessels but caused a severe reduction in the frequency of B cells in LNs.The LEC-specific NIK deficiency did not affect the survival of B cells or the frequency of B cells in the spleen.B-cell adoptive transfer studies revealed that the LEC-specific NIK deletion impairs the ability of LNs to recruit B cells.We further show that NIK mediates expression of the chemokines CXCL13 and CCL19 in LECs.Although CCL19 is also expressed in blood endothelial cells(BECs),CXCL13 is not produced in BECs.These results suggest that NIK regulates naive B-cell homing to LNs via mediating production of the B-cell homing chemokine CXCL13 in LECs. | Jie Yang Siya Zhang Lingyun Zhang Xiaoping Xie Hui Wang Zuliang Jie Meidi Gu Jin-Young Yang Xuhong Cheng Shao-Cong Sun | 2019 | Cellular & Molecular Immunology2019，16，2： | 1 |
| 4 | Acoustofluidics for cell patterning and tissue engineering显示文摘Acoustofluidics has been a promising approach using sound waves to manipulate particles and actuate fluids in biomedical applications.It usually generates acoustic radiation force and acoustic streaming to initiate diffraction,reflection and interference,building up a pressure distribution to facilitate accurate manipulation of micro-or nano-scale particles and fluids.Owing to its remarkable contact-free and biocompatible advantages,acoustoflu-idics has been used in high-throughput cell analysis,size-controllable organoid structures,and functional tissue mimics.We enumerate the basic concepts and the sufficient research of acoustofluidics in precise patterning and tissue engineering in this review,including the design and function of four typical acoustofluidic devices,var-ious forms of cell patterning and 3D tissue engineering.Meanwhile,we outlined current challenges and future directions of acoustofluidics in biomedicine and tissue engineering. | Zhuhao Wu Meidie Pan Jinglin Wang Baojie Wen Ling Lu Haozhen Ren | 2022 | Engineered Regeneration2022，3，4： | 1 |
| 5 | Aqueous Two-Phase Interfacial Assembly of COF Membranes for Water Desalination显示文摘Aqueous two-phase system features with ultralow interfacial tension and thick interfacial region,affording unique confined space for membrane assembly.Here,for the first time,an aqueous two-phase interfacial assembly method is proposed to fabricate covalent organic framework(COF)membranes.The aqueous solution containing polyethylene glycol and dextran undergoes segregated phase separation into two water-rich phases.By respectively distributing aldehyde and amine monomers into two aqueous phases,a series of COF membranes are fabricated at water-water interface.The resultant membranes exhibit high NaCl rejection of 93.0-93.6% and water permeance reaching 1.7-3.7 L m^(−2) h^(−1) bar^(−1),superior to most water desalination membranes.Interestingly,the interfacial tension is found to have pronounced effect on membrane structures.The appropriate interfacial tension range(0.1-1.0 mN m^(−1))leads to the tight and intact COF membranes.Furthermore,the method is extended to the fabrication of other COF and metal-organic polymer membranes.This work is the first exploitation of fabricating membranes in all-aqueous system,confering a green and generic method for advanced membrane manufacturing. | Hongjian Wang Jiashuai Zhao Yang Li Yu Cao Ziting Zhu Meidi Wang Runnan Zhang Fusheng Pan Zhongyi Jiang | 2022 | Nano-Micro Letters2022，14，12： | 1 |
| 6 | Synergistic effects of chemical additives and mature compost on reducing H_2S emission during kitchen waste composting显示文摘Additives could improve composting performance and reduce gaseous emission,but few studies have explored the synergistic of additives on H_(2)S emission and compost maturity.This research aims to make an investigation about the effects of chemical additives and mature compost on H_(2)S emission and compost maturity of kitchen waste composting.The results showed that additives increased the germination index value and H_(2)S emission reduction over 15 days and the treatment with both chemical additives and mature compost achieved highest germination index value and H_(2)S emission reduction(85%).Except for the treatment with only chemical additives,the total sulfur content increased during the kitchen waste composting.The proportion of effective sulfur was higher with the addition of chemical additives,compared with other groups.The relative abundance of H_(2)S-formation bacterial(Desulfovibrio)was reduced and the relative abundance of bacterial(Pseudomonas and Paracoccus),which could convert sulfur-containing substances and H_(2)S to sulfate was improved with additives.In the composting process with both chemical additives and mature compost,the relative abundance of Desulfovibrio was lowest,while the relative abundance of Pseudomonas and Paracoccus was highest.Taken together,the chemical additives and mature compost achieved H_(2)S emission reduction by regulating the dynamics of microbial community. | Yongdi Liu Haihou Wang Hao Zhang Yueyue Tao Rui Chen Sheng Hang Xiaoyan Ding Meidi Cheng Guochun Ding Yuquan Wei Ting Xu Ji Li | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 7 | TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells显示文摘Generation and maintenance of antigen-specific effector and memory T cells are central events in immune responses against infections.We show that TNF receptor-associated factor 2(TRAF2)maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against infections.This signaling axis involves activation of Tpl2 and its downstream kinase ERK by NF-κB-inducing kinase(NIK)and degradation of the proapoptotic factor Bim.NIK mediates Tpl2 activation by stimulating the phosphorylation and degradation of the Tpl2 inhibitor p105.Interestingly,while NIK is required for Tpl2-ERK signaling under normal conditions,uncontrolled NIK activation due to loss of its negative regulator,TRAF2,causes constitutive degradation of p105 and Tpl2,leading to severe defects in ERK activation and effector/memory CD8 T cell survival.Thus,TRAF2 controls a previously unappreciated signaling axis mediating effector/memory CD8 T cell survival and protective immunity. | Xiaoping Xie Lele Zhu Zuliang Jie Yanchuan Li Meidi Gu Xiaofei Zhou Hui Wang Jae-Hoon Chang Chun-Jung Ko Xuhong Cheng Shao-Cong Sun | 2021 | Cellular & Molecular Immunology2021，18，9： | 0 |
| 8 | Enhanced desulfurization performance of hybrid membranes using embedded hierarchical porous SBA-15显示文摘The utilization of materials with a hierarchical porous structure as multi-functional additives is highly attractive in the preparation of hybrid membranes.In this study,novel hybrid membranes are designed by embed-ding hierarchical porous Santa Barbara Amorphous 15(SBA-15)with a dual-pore architecture(micropores and mesopores)for pervaporation desulfurization.The SBA-15 with cylindrical mesopores provides molecular transport expressways to ensure improved permeability,while micropores on the wall have molecular sieving effects that are essential for the enhancement of permselectivity of thiophene molecules.Considering thiophene/n-octane mixture as a model system,the hybrid membrane with embedded 6 wt-%SBA-15 exhibits optimal pervaporation desulfurization performance with a permeation flux of 22.07 kg·m^-2·h^-1 and an enrichment factor of 6.76.Moreover,the detailed structure and properties of hybrid membranes are systematically characterized.This study demonstrates the immense potential of hierarchical porous materials as additives in membranes to simultaneously increase permeability and permselectivity. | Ye Zhang Jian Song Josue Quispe Mayta Fusheng Pan Xue Ga Mei Li Yimeng Song Meidi Wang Xingzhong Cao Zhongyi Jiang | 2020 | Frontiers of Chemical Science and Engineering2020，14，4： | 0 |
| 9 | Fine mapping of Brebm6,a gene conferring the early-bolting phenotype in Chinese cabbage(Brassica rapa ssp.pekinensis)显示文摘In flowering plants,bolting signals the transition from vegetative to reproductive growth,and it is consequently an important agronomic trait for the stalk-use Chinese cabbage Baicaitai.There is an urgent need to create germplasm resources for Chinese cabbage that have easy bolting characteristics.In this investigation,early bolting mutant 6(ebm6)was created by treating Chinese cabbage double haploid(DH)'FT'seeds with an ethyl methanesulfonate(EMS)solution.Phenotypic analysis showed that the mutant ebm6 flowered remarkably earlier than the wild-type'FT'.Genetic analysis indicated that this early bolting trait was controlled by a recessive nuclear gene.In mutant ebm6,the causal gene BraA02g003340.3C(BrFLC2)was predicted using MutMap and Kompetitive Allele Specific PCR genotyping(KASP),as the gene encodes a MADSbox transcription factor.The 3259-bp BrFLC2 gene possessed seven exons and six introns,and in the first exon,a single nucleotide C-to-T substitution in the highly conserved MADS-box domain resulted in the premature termination of translation of the BrFLC2 protein sequence.This research supported a critical role of BrFLC2 in controlling flowering time in B.rapa.The early flowering ebm6 mutant could also be a useful material in Baicaitai breeding. | Wei Fu Shengnan Huang Zhiyong Liu Yue Gao Meidi Zhang Nan Wang Gaoyang Qu Hui Feng | 2021 | Vegetable Research2021，1，1： | 0 |
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