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| 1 | 不同起始细胞数量对旋链角毛藻和中肋骨条藻种群竞争的影响显示文摘分析了起始细胞数对中肋骨条藻(Skeletonema costatum)和旋链角毛藻(Chaetoceros curvisetus)种群增长的影响。结果表明,单种培养的情况下,不同起始细胞数量对中肋骨条藻和旋链角毛藻种群细胞数有显著的影响,随起始细胞数的增加种群细胞数有增加的趋势。按不同接种比例进行混合培养,两种藻生长均受到抑制,而且中肋骨条藻降低的程度远大于旋链角毛藻。经计算,旋链角毛藻的种间竞争能力明显强于中肋骨条藻,抑制能力是中肋骨条藻抑制能力的11倍。 | 茅华 许海 刘兆普 MEHTA S K | 2008 | 海洋环境科学2008，27，5： | 14 |
| 2 | Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation显示文摘AIM:To investigate whether the inhibition of autophagy by chloroquine(CQ)sensitizes rectal tumors to radiation therapy(RT)or concurrent chemoradiation(chemoRT).METHODS:In vitro,HCT-116 and HT-29 colorectal cancer(CRC)cell lines were treated as following:(1)PBS;(2)CQ;(3)5-fluorouracil(5-FU);(4)RT;(5)CQ and RT;(6)5-FU and RT;(7)CQ and 5-FU;and(8)5-FU and CQ and RT.Each group was then exposed to various doses of radiation(0-8 Gy)depending on the experiment.Cell viability and proliferative capacity were measured by3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and clonogenic assays.Clonogenic survivalcurves were constructed and compared across treatment groups.Autophagy status was determined by assessing the LC3-Ⅱto LC3-Ⅰratio on western blot analysis,autophagosome formation on electron microscopy and identification of a perinuclear punctate pattern with GFPlabeled LC3 on fluorescence microscopy.Cell cycle arrest and cell death were evaluated by FACS and AnnexinⅤanalysis.All experiments were performed in triplicate and statistical analysis was performed by the student’s t test to compare means between treatment groups.RESULTS:RT(2-8 Gy)induced autophagy in HCT-116and HT-29 CRC cell lines at 4 and 6 h post-radiation,respectively,as measured by increasing LC3-Ⅱto LC3-Ⅰratio on western blot.Additionally,electron microscopy demonstrated autophagy induction in HT-29 cells24 h following irradiation at a dose of 8 Gy.Drug treatment with 5-FU(25μmol/L)induced autophagy and the combination of 5-FU and RT demonstrated synergism in autophagy induction.CQ(10μmol/L)alone and in combination with RT effectively inhibited autophagy and sensitized both HCT-116 and HT-29 cells to treatment with radiation(8 Gy;P<0.001 and 0.00001,respectively).Significant decrease in clonogenic survival was seen only in the HT-29 cell line,when CQ was combined with RT at doses of 2 and 8 Gy(P<0.5 and P=0.05,respectively).There were no differences in cell cycle progression or Annexin V staining upon CQ addition to RT.CONCLUSION:Autophagy inhibition by CQ increases CRC cell sensitivity to concurrent treatment with 5-FU and RT in vitro,suggesting that addition of CQ to chemoRT improves CRC treatment response. | Caitlin A Schonewolf Monal Mehta Devora Schiff Hao Wu Bruce G Haffty Vassiliki Karantza Salma K Jabbour | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 12 |
| 3 | Inflammation and dry eye disease——where are we?显示文摘The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear dysfunction.It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease.This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed. | Srinivas K Rao Rishi Mohan Nikhil Gokhale Himanshu Matalia Paras Mehta | 2022 | International Journal of Ophthalmology(English edition)2022，15，5： | 4 |
| 4 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 5 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 6 | Anti-arthritis activity of roots of Hemidesmus indicus R.Br.(Anantmul)in rats显示文摘Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of rodents.Methods:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus indicus.Arthritis rats models were established by Complete Freund’s Adjuvant.The parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were observed.Methotrexate was taken as positive control.Results:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual fraction.Histopathological analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with methotrexates.Conclusions:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction. | Alka Mehta Neeraj K Sethiya Chetan Mehta GB Shah | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 4 |
| 7 | Greening of the concrete industry for sustainable development 显示文摘 | Mehta P K | 2002 | Concrete International2002，24，7： | 2 |
| 8 | Durability--Critical issues for the future显示文摘 | Mehta P K | 1997 | Concrete International1997，19，： | 2 |
| 9 | Tissue transglutaminase inhibits autophagy in pancreatic cancer cells显示文摘 | Akar U Ozpolat B Mehta K | 2007 | Mol Cancer Res2007，5，3： | 1 |
| 10 | Aminotransferases:demonstration of homology and division into evolutionary subgroups显示文摘 | Hale T I and Christen P | 1993 | Eur J Biochem1993，214，： | 1 |
| 11 | Cracking - corrosion interaction inconcrete exposed to marine environment 显示文摘 | MEHTA P K GERWICK B C | 1982 | Concrete Interna- tional1982，4，10： | 1 |
| 12 | Concrete deterioration from physical attack by salts 显示文摘 | Haynes H O’Neill R Mehta P K | 1996 | Concr Int1996，18，1： | 1 |
| 13 | Effects of organic compounds on the degradation of p-nitrophenol in lake and industrial wastewater by inoculated bacteria显示文摘 | Zaidi B R Mehta N K | 1995 | Biodesradation1995，6，： | 1 |
| 14 | Building durable structures in the 21st century显示文摘 | Mehta P K Burrows R W | 2001 | Concrete Int2001，23，3： | 1 |
| 15 | Large-scale sequence analysis of avian influenza isolates显示文摘 | Obenauer J C Denson J Mehta P K | 2006 | Science2006，311，5767： | 1 |
| 16 | Cut slope stability evaluation of NH-21 along Nalayan-Gambhrola section,Bilaspur district,Himachal Pradesh,India显示文摘 | Sharma R K Mehta B S Jamwal C S | | 0，，： | 1 |
| 17 | Face recognition using scale-adap- tive directional and textural features 显示文摘 | MEHTA R EGIAZARIAN K | 2014 | Pattern Recognition2014，47，5： | 1 |
| 18 | Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants显示文摘 | Mehta K Van Thiel DH Shah N | 2002 | Nutr Rev2002，60，9： | 1 |
| 19 | Principles underlying production of high-performance concrete 显示文摘 | AITCIN P C | 1990 | Cem Concr Aggregate1990，12，2： | 1 |
| 20 | Durability critical issues for the future 显示文摘 | Mehta P K | 1997 | Concrete International1997，19，7： | 1 |
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