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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 3 | Studies on pendimethalin and fluchloralin residues in soil and onion 显示文摘 | Sharma R Mehta H M | 1989 | Indian J Agron1989，34，2： | 1 |
| 4 | Simulaneous pattern reversal ERG and VEP recordings effect of stimnlus field and central scotoma显示文摘 | Sakaue H Katsumi O Mehta M | 1990 | Imest Ophthalmol Vis Sci1990，31，： | 1 |
| 5 | Growth as a eorreetive force in the early treatment of progressive infantile seoliosis 显示文摘 | Mehta M H | 2005 | J Bone Joint Surg Br2005，87，： | 1 |
| 6 | Amyloid-beta protein dimers isolated directly from Alzheimer' s brains impair synaptic plasticity and memory显示文摘 | Shankar G M Li S Mehta T H | | 0，，08： | 1 |
| 7 | Acuate myocardial infarction in the elderly:Differences by age显示文摘 | Mehta R H Rather S S Radford M J | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 8 | Triage after hospitalization with advanced heart failure : the ESCAPE ( E- valuation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score显示文摘 | O'CONNOR C M HASSELBLAD V MEHTA R H | 2010 | J Am Coil Cardiol2010，55，9： | 1 |
| 9 | Comparison of use- fulness of secondary prevention of coronary disease in pa- tients < 80 versus ≥ 80 years of age 显示文摘 | Mehta H Sacrinty M Johnson D | 2013 | Am J Cardiol2013，112，8： | 1 |
| 10 | Reproductive and developmental toxicity of dioxin in fish 显示文摘 | KING H T C MEHTA V XIONG K M | 2012 | Molecular and Cellular Endocrinology2012，354，： | 1 |
| 11 | Thermal alteration of sandstones显示文摘 | Somerton W H Mehta M M Dean G W | 1965 | JPT1965，17，5： | 1 |
| 12 | Comparison of nerve growth factor receptor binding models using heterodimeric muteins 显示文摘 | MEHTA H M WOO S B NEET K E | 2012 | J Neurosci Res2012，90，12： | 1 |
| 13 | Amyloid-beta protein dimers i- solated directly from Alzheimer~ brains impair synaptic plasticity and memory 显示文摘 | Shankar G M Li S Mehta T H | 2008 | Nat Med2008，14，8： | 1 |
| 14 | Benzyl ester of dehydrated castor oil fatty acid as plasticizer for poly(vinyl chloride) 显示文摘 | Mehta B H Kathalewar M Sabnis A | 2014 | Polymer International2014，63，8： | 1 |
| 15 | Frequent monitoring of A1C during pregnancy as a treatment tool to guide therapy显示文摘 | Jovanovic L Savas H Mehta M | 2011 | Diabetes Care2011，34，1： | 1 |
| 16 | Novel femoral artery puncture closure device in patients undergoing interventional and dignostic cardiac procedures显示文摘 | Mehta H Fleisch M Chatterjee T | 2002 | J Invasive Cardiol2002，14，1： | 1 |
| 17 | Thermal alteration of Sandstone 显示文摘 | Somerton W H Mehta M M Dean G W | 1965 | JPet Tech1965，50，： | 1 |
| 18 | Compost: Its role, mechanism and impact on reducing soil-borne plant diseases显示文摘 | Mehta C M Palni U Franke-Whittle I H | 2014 | Waste Management2014，34，3： | 1 |
| 19 | Studies on pendimethalin and fluchloralin residues in soil and onion显示文摘 | Sharma R Mehta H M | 1989 | Indian J Agron1989，34，2： | 1 |
| 20 | Dimethyl fumarate inhibits dendritic cell maturation via nuclear factorκB(NF-κB)and extracellular signal-regulated kinase 1 and 2(ERK1/2)and mitogen stress-activated kinase 1(MSK1)signaling显示文摘 | Peng H Guerau-de-Arellano M Mehta VB | 2012 | J Biol Chem2012，287，28： | 1 |
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