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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Electrodeless plasma thrusters for spacecraft: a review显示文摘The physics of electrodeless electric thrusters that use directed plasma to propel spacecraft without employing electrodes subject to plasma erosion is reviewed. Electrodeless plasma thrusters are potentially more durable than presently deployed thrusters that use electrodes such as gridded ion,Hall thrusters, arcjets and resistojets. Like other plasma thrusters, electrodeless thrusters have the advantage of reduced fuel mass compared to chemical thrusters that produce the same thrust. The status of electrodeless plasma thrusters that could be used in communications satellites and in spacecraft for interplanetary missions is examined. Electrodeless thrusters under development or planned for deployment include devices that use a rotating magnetic field; devices that use a rotating electric field; pulsed inductive devices that exploit the Lorentz force on an induced current loop in a plasma; devices that use radiofrequency fields to heat plasmas and have magnetic nozzles to accelerate the hot plasma and other devices that exploit the Lorentz force. Using metrics of specific impulse and thrust efficiency, we find that the most promising designs are those that use Lorentz forces directly to expel plasma and those that use magnetic nozzles to accelerate plasma. | S N BATHGATE M M M BILEK D R MCKENZIE | 2017 | Plasma Science and Technology2017，19，8： | 6 |
| 3 | A potent new class of reductively activated peptide gene delivery agents显示文摘 | McKenzie D L Kwok K Y Rice K G | 2000 | J Biol Chem2000，275，14： | 1 |
| 4 | The geometrical evolution of normal fault systems 显示文摘 | Jackson J A McKenzie D P | 1983 | Journal of Structural Geology1983，5，： | 1 |
| 5 | Effect of upper extremity exer- cise on secondary lymphedema in breast cancer patients: a pi- lot study 显示文摘 | McKenzie D C Kalda A L | 2003 | J Clln Chacol2003，21，3： | 1 |
| 6 | Temporal carbon dynamics of forests in Washington, US : Implications for ecological theory and carbon management显示文摘 | Raymond C L McKenzie D | 2013 | Forest Ecology and Management2013，310，： | 1 |
| 7 | Anti- PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy显示文摘 | Kanigicherla D Gummadova J McKenzie EA | 2013 | Kidney Int2013，83，5： | 1 |
| 8 | Functional properties of protein i-solates from beach pea显示文摘 | Chavan V D Mckenzie D B | 2001 | Food Chemistry2001，74，： | 1 |
| 9 | A review of space tether re-search 显示文摘 | CARTMELL M P MCKENZIE D J | 2008 | Progress in Aerospace Sciences2008，44，1： | 1 |
| 10 | über oxals? ure-und weins? ure-bornylester显示文摘 | ABBOT E B MCKENZIE A ROSS J D M | 1938 | Berichte Der Deutschen Chemischen Gesellschaft1938，71，1： | 1 |
| 11 | Automated cell colony counting and analysis using the circular Hough image transform algorithm(CHiTA) 显示文摘 | Bewes J M Suchowerska N McKenzie D R | 2008 | Physics in Medicine and Biology2008，53，21： | 1 |
| 12 | Partial melt distributions from inversion of rare earth element concentrations显示文摘 | McKenzie D O'Nions R K | 1991 | J Petrol1991，32，5： | 1 |
| 13 | Markers of Excessive Exercise显示文摘 | MCKENZIE D C | 1999 | Can J Appl Physiol1999，24，1： | 1 |
| 14 | The host range of chronic wasting disease is altered on passage in ferrets显示文摘 | BartzJ C Marsh R F mckenzie D I | 1998 | Virology1998，251，2： | 1 |
| 15 | The source regions of ocean island basalts 显示文摘 | McKenzie D O'Nions R K | 1995 | JPetrol1995，36，1： | 1 |
| 16 | Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP显示文摘 | KRISHNAMURTHY B DUDEN N L MCKENZIE M D | 2006 | J Clin Invest2006，116，： | 1 |
| 17 | A thin viscous sheet model for continental deformation显示文摘 | England P Mckenzie D | 1983 | Geophys J R Ast ron Soc1983，70，： | 1 |
| 18 | Solar observations from the P78-1 satellite显示文摘 | MCKENZIE D L LANDECKER P B | 1982 | Astrophys J1982，254，： | 1 |
| 19 | The orientation dependence of elastic strain energy in cubic crystalsand its application to preferred orientation in titanium nitrides thin films 显示文摘 | Mckenzie D R Yin Y Mcfall W D | 1996 | J Phys1996，32，： | 1 |
| 20 | The Prudence of Mexican Consumers显示文摘 | Mckenzie D J | 2002 | Economia Mexicana Nueva? poca2002，11，2： | 1 |
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