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128篇 您的检索式：作者名="Mcelduff"

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	题名	作者	年代	出处	被引量
1	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
2	A method for meta-analysis of molecular association studies显示文摘	Thakkinstian A McElduff P D~Este C	2005	Stat Med2005，24，：	1
3	Current smoking and the risk of non-fatal myocardial infarction in the WHO MONICA Project populations显示文摘	Mahonen M S McElduff P J Dobson A	2004	Tob Control2004，13，：	1
4	Assessment and reproducibility of Non-eosinophilic asthma using induced sputum 显示文摘	Simpson JL McElduff P Gibson PG	2010	Respiration2010，79，2：	1
5	Vitamin D and pregnancy:An old problem revisited显示文摘	Barrett H McElduff A	2010	Best Pract Res Clin Endocrinol Metab2010，24，：	1
6	Pulmonary insulin administration using the AERx system: physiological and physicochemical factors influencing insulin effectiveness in healthy fasting subjects 显示文摘	Farr SJ Mcelduff A MatherLE	2000	Diabetes Technol Ther2000，2，2：	1
7	Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study 显示文摘	MACKNESS B DURRINGTON P MCELDUFF P	2003	Circulation2003，107，22：	1
8	Maternal vitamin D deficiency, ethnicity and gestational diabetes显示文摘	Clifton-Bligh R J McElduff P McElduff A	2008	Diabet Med2008，25，6：	1
9	Currentsmoking and the risk of non-fatal myocardial infarction in the WHO MONICA Project populations显示文摘	Mahonen MS Mcelduff P Dobson AJ	2004	Tob Control2004，13，3：	1
10	High C-reactive protein and low paraoxonasel in diabetes as risk factors for coronary heart disease 显示文摘	Mackness B Hine D McElduff P	2006	Atherosclerosis2006，186，2：	1
11	Low paraoxonase activity predicts coronary events in the caerphilly prospective study显示文摘	Mackness B Durrington P McElduff P	2003	Circulation2003，107，22：	1
12	High C-reactive protein and low paraoxonase 1 in diabetes as risk factor for cor- onary heart disease 显示文摘	Mackness B Hine D McElduff P Mackness M	2006	Atherosclerosis2006，186，2：	1
13	A method for meta analysis of molecular association studies 显示文摘	Thakkinstian A McElduff P D'Este C	2005	Star Med2005，24，：	1
14	Cold periods and coronary events:an analysis of populations worldwide显示文摘	Barnett AG Dobson AJ McElduff P	2005	J Epidemiol Community Health2005，59，7：	1
15	Cord blood lipoproteins and prenatal influences显示文摘	Bansal N Cruickshank JK McElduff P	2005	Curr Opin Lipidol2005，16，4：	1
16	Defining the extent of irreversible brain ischemia using perfusion computed tomography显示文摘	Bivard A McElduff P Spratt N		0，，03：	1
17	The relationship among homocysteine,creatinine clearance,and albuminuria in patients with type 2 diabetes显示文摘	Davies L Wilmshurst EG McElduff A	2001	Diabetes Care2001，24，：	1
18	Progestogens of varying androgenicity and cardiovascular risk factors in postmenopausal women receiving oestrogen replacement therapy 显示文摘	KWOK S SELBY PL MCELDUFF P	2004	Clin Endocrinol(Oxf)2004，61，6：	1
19	Constipation in australian women: prevalence and associated factors显示文摘	P Chiarelli W Brown P McElduff	2000	International Uro- gynecology Journal2000，11，2：	1
20	Leaking urine: Prevalence and associated factors in Australian women显示文摘	Chiarelli P Brown W McElduff F P	1999	Neurourol Urodyn1999，18，6：	1

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