|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak 显示文摘 | McCarthy NJ Whyte MK Gilbert CS | 1997 | J Cell Biol1997，136，1： | 1 |
| 3 | The regulation of vascular smooth muscle cell apoptosis 显示文摘 | Mccarthy NJ Bennett MR | 2000 | Cardiovase Res2000，45，3： | 1 |
| 4 | Inhibition of Ced-3/ICE-related protease does not prevent cel death induced hy oncogenes,DNA damage,or the Bcl-2 homologue Bak显示文摘 | McCarthy NJ Whyle MK Gilbert CS | 1997 | J Cell Biol1997，136，1： | 1 |
| 5 | The regulation of vascular smooth muscle cell apoptosis显示文摘 | McCarthy NJ Bennett MR | | 0，，03： | 1 |
| 6 | Nasal defor- mities resulting from flow driver continuous positive airway pressure 显示文摘 | Robertson NJ McCarthy LS Hamihon PA | 1996 | Arch D is Child Fetal Neonatal Ed1996，75，3： | 1 |
| 7 | Nasal deformities resulting from flow driver continuous positive airway pressure 显示文摘 | Robertson NJ McCarthy LS Hamilton PA | 1996 | Arch Dis Child Fetal Neonatal Ed1996，75，3： | 1 |
| 8 | Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women 显示文摘 | ZAIDI FK WAREHAM NJ MCCARTHY MI | 1997 | Diabet Med1997，14，3： | 1 |
| 9 | Inhibition of Ced-3/ICE- related proteases does not prevent cell death induced by oncogenes, DNA damage,or the Bcl-2 homologue Bak显示文摘 | McCarthy NJ Whyte MK Gilbert CS | 1997 | J Cell Biol1997，136，1： | 1 |
| 10 | The regulation of vascular smooth tousle cell apoptosis 显示文摘 | McCarthy NJ Bennett MR | 2000 | Cardiovasc Res2000，45，： | 1 |
| 11 | Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak显示文摘 | Whyte MK Gilbert CS | 1997 | J Cell Biol1997，136，： | 1 |
| 12 | Modification of paper properties by the pretreatment of pulp with Saccharomonospora viridis xylanase显示文摘 | Roberts JC McCarthy AJ Flynn NJ Broda P | 1990 | Enzyme and Microbial technology1990，12，3： | 1 |
| 13 | Homozygosity for a common polymorphism in the islet-specific promter of the glueokinase gene is assoeitaed with a reduced early insulin response to oral glucose in pregnant woman显示文摘 | Zaidi FK Wareham NJ McCarthy MI | 1997 | Diabetes Med1997，14，3： | 1 |
| 14 | Nasal deformities resulting from flow driver continuous positive airway pressure 显示文摘 | Robertson NJ McCarthy LS Hamilton PA | 1996 | Arch Dis Child Fetal Neonatal Ed1996，75，3： | 1 |
| 15 | Apoptosis:final control point in cellbiology显示文摘 | Wil iams GT Smith CA McCarthy NJ | | 0，，09： | 1 |
| 16 | Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak显示文摘 | Whyte MKB Gilbert CS | 1997 | J Cell Biol1997，136，： | 1 |
| 17 | Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak 显示文摘 | Whyte MKB Gilbert CS | 1997 | J Cell Biol1997，136，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员