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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | MCCARTHY M A LAWLOR V P STANLEY W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 3 | Application of Genetic Modification Techni-ques in the Production of Textile Fibres显示文摘 | Hamlyn P F McCarthy B J | 2001 | Review of Progress in Colora-tion and Related Topics2001，，31： | 1 |
| 4 | Evaluation of the antioxidant potential of natural food/plant extracts as compared with synthetic antioxidants and vitamin E in raw and cooked pork patties显示文摘 | McCarthy T L Kerry J P Kerry J F | 2001 | Meat Science2001，58，1： | 1 |
| 5 | Anatomy, pathologic features, and treatment of acetabular labral tears显示文摘 | McCarthy J C Noble P C Aluisio F V | 2003 | Clin Orthop Re- lat Res2003，，406： | 1 |
| 6 | Synthesis and characterization of a series of poly(al-kylene carbonate)macrodiols and the effect of their structure on the properties of polyurethanes 显示文摘 | Gunatillake P A Me(is G F McCarthy S J | 1998 | Journal of Applied Polymer Science1998，69，8： | 1 |
| 7 | Mechanisms of dissolved organic carbon adsorption on soil 显示文摘 | Jardine P M Mccarthy J F Weber N L | 1989 | Soil Science Society of A-merica Journal1989，53，5： | 1 |
| 8 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | Mccarthy M A Lawlor V P Stanley W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 9 | Evaluation of the antioxidant potential of natural food/plant extracts as compared with synthetic antioxidants and vitamin E in raw and cooked pork patties显示文摘 | McCARTHY T L KERRY J P KERRY J F | 2001 | Meat Science2001，57，： | 1 |
| 10 | Synthesis, Charac terization, and Stability of Poly 显示文摘 | Mccarthy S J Meijs G F Gunatillake P | 1997 | J Appl Polym Sci1997，65，7： | 1 |
| 11 | A phase Ⅱ trial of docetaxel and cisplatin in patients with recurrent or metastatic nasopharyngeal carcinoma显示文摘 | McCarthy J S Tannock I F Degendorfer P | 2002 | Oral Oncol2002，38，7： | 1 |
| 12 | Right ventricular dysfunction mad dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans显示文摘 | PARKER M M MCCARTHY K E OGNIBENE F P | 1990 | Chest1990，97，1： | 1 |
| 13 | Impaired myofibrillar ener- geties and oxidative injury during human atrial fibrilla- tion显示文摘 | Mihm M J Yu F Carnes C A Reiser P J McCarthy P M van Wagoner D R | 2001 | Circulation2001，104，： | 1 |
| 14 | Nonmarlne sequence stratigraphy : Updip expression of sequence boundaries and systems tracts in a highesolution framework, Cenomanian Dunvegan Formation, Alberta foreland basin, Canada显示文摘 | Plint A G McCarthy P J Faccini U F | 2001 | AAPG Bulletin2001，85，： | 1 |
| 15 | Synthesis and characterizatioa of a series of pely(alkylene carbonate)macrodiols and the effect of their structure on the properties of polyurethanes显示文摘 | Gunatillake P A Meijs G F McCarthy S J | 1998 | Journal of Applied Polymer Science1998，69，8： | 1 |
| 16 | Right ventricular dysfunction and dilatation,similar to left ventricular hanges,charterize the cardiac depression of septic shock in humans显示文摘 | Parker M M McCarthy K E Ognibene F P | | 0，，01： | 1 |
| 17 | Mechanisms of dissolved carbon adsorption on soil 显示文摘 | Jardine P M Weber N L McCarthy J F | 1989 | Soil Science Society of America Journal1989，3，： | 1 |
| 18 | Mechanisms of dissolved organic carbon adsorption on soil显示文摘 | JARDINE P M WEBER N L MCCARTHY J F | 1989 | Soil Sci Soc Amer J1989，53，5： | 1 |
| 19 | Evidence implicating peroxisome proliferator-activated receptor-α in the pathogenesis of preeclampsia显示文摘 | McCarthy F P Drewlo S English F A Kingdom J Johns E J Kenny L C | 2011 | Hypertension2011，58，： | 1 |
| 20 | Unlocking the power of innovation显示文摘 | BLAKENEY B A CARLETON P F MCCARTHY C COAKLEY E | 2009 | The Online Journal of Issues in Nursing2009，14，2： | 1 |
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