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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Enzymatic Degradability of Poly(lactide) :Effects of chain stereochemistry and material crystallinity 显示文摘 | REEVE M MCCARTHY S P GROSS R A | 1996 | Macromolecules1996，29，23： | 1 |
| 3 | Preliminary Views on the Potential of Foamed Concrete as a Structural Material显示文摘 | Jones M R McCarthy A | 2005 | Magazine of Con crete Research2005，57，1： | 1 |
| 4 | Mdeling of Bird Strike on an Aircraft wing Leading Edge Made from Fiber Metal Laminates Partl : Material Modeling 显示文摘 | McCarthy M A Xiao J R Petrinic C T | 2004 | Aplied Com- posite Materials2004，11，5： | 1 |
| 5 | 1 l-Ketotigogenin cellobioside (pamaqueside): a potent cholesterol absorption inhibitor in the hamster显示文摘 | McCarthy P A DeNinno M P Morehouse L A | 1996 | J Med Chem1996，39，10： | 1 |
| 6 | Redefining the stormwater first flush phenomenon 显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Research2010，44，8： | 1 |
| 7 | Estrogenicity of pyrethroid insecticide metabolites显示文摘 | MCCARTHY A R THOMSON B M SHAW I C | 2006 | Journal of Environmental Monitoring2006，8，： | 1 |
| 8 | Clifford Algebra Expo- nentials and Planar Linkage Synthesis Equations 显示文摘 | Perez A McCarthy J M | | Journal of Mechanical Design0，127，5： | 1 |
| 9 | Nutrient data on chestnuts consumed in the United States显示文摘 | McCARTHY M A MEREDITH F I | 1988 | Economic Botany1988，42，1： | 1 |
| 10 | Mice lacking neu- trophil elastase reveal impaired host defense against gram negative bacterial sepsis 显示文摘 | Belaaouaj A McCarthy R Baumann M | 1998 | Nat Med1998，4，： | 1 |
| 11 | The develop- ment of a novel approach for assessment of the first flush in urban stormwater discharges显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Science and Technol- ogy2010，61，10： | 1 |
| 12 | Finite Element Analysis of the Effects of Clearance on Single Shear, Composite Gohed Joints显示文摘 | MCCARTHY M A MCCARTHY C T | 2003 | J Plastic Rubbers Composites2003，32，2： | 1 |
| 13 | Insulin like growth factor-l-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC) 1/TSC2 in C2C12 myotubes 显示文摘 | Miyazaki M McCarthy J J Esser K A | 2010 | FEBS J2010，277，9： | 1 |
| 14 | Phylogenetic community structure in Minnesota oak savanna is influenced by spatial extent and environmental variation 显示文摘 | Willis C G Halina M Lehman C Rcich P B Keen A McCarthy S Cavender-Bares J | 2010 | Ecography2010，33，： | 1 |
| 15 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | MCCARTHY M A LAWLOR V P STANLEY W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 16 | A simple method for determining the effect of bolt hole clear ance on load distribution in single column multi-bolt compos ite joints显示文摘 | MCCARTHY M A MCCARTHY C T PADHI G S | 2006 | Composite Structures2006，73，1： | 1 |
| 17 | An antibody- and synthetic peptide-defined rubella virus E1 glycoprotein neutraliza- tiondomain显示文摘 | Wolinsky J S Sukholutsky E Moore W T Lovett A McCarthy M Adame B | 1993 | J Virol1993，67，2： | 1 |
| 18 | In vitro interactions between farnesol and fluconazole,amphotericin B or micafungin against Candida albicans biofilms显示文摘 | Katragkou A McCarthy M Alexander EL | 2015 | J Antimicrob Chemother2015，70，2： | 1 |
| 19 | Mechanisms of nitrous oxide formation in coal flames显示文摘 | Kramlich J C Cole J A McCarthy J M | | 0，，： | 1 |
| 20 | Three-dimensional finite element analysis of single-bolt, single-lap composite bolted joints: Part If--Effects of bolt-hole clearance 显示文摘 | MCCARTHY C T MCCARTHY M A | 2005 | Composite Structures2005，71，2： | 1 |
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