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| 1 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 3 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Bias correction for individual realization laser Doppler measurements in turbulent flows显示文摘 | Tiedermann W G | 1973 | Phys of Fluids1973，16，： | 1 |
| 5 | Extraction and separation of urinary catecholamines as their diphenyl boronate complexes using C 18 solid-phase extraction sorbent and high-performance liquid chromatography显示文摘 | Talwar D Williamsou C McLaughlin A | 2002 | Chromatogr B2002，769，2： | 1 |
| 6 | Hyperfine Zeeman effect atomic absorption spectrometer for mercury显示文摘 | Hadeishi T McLaughlin R D | 1971 | Science1971，，： | 1 |
| 7 | An integrated approach to hydrologic data assimilation: interpolation, smoothing, and filtering显示文摘 | MCLAUGHLIN D | 2002 | Advances in Water Resources2002，25，8： | 1 |
| 8 | ACCF/AHA 2009 expert consensus docu- ment on pulmonary hypertension a report of the A- merican College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians显示文摘 | MCLAUGHLIN V V ARCHER S L BADESCH D B | 2009 | J Am Coil Cardiol2009，53，： | 1 |
| 9 | Delayed sternal closure after cardiac operations in a pediatric population 显示文摘 | Tabbutt S Duncan BW McLaughlin D | 1997 | Thorae Cardio- vase Surg1997，113，5： | 1 |
| 10 | Performance of the GLRT for adaptive vector subspace detection显示文摘 | Raghavan R S Pulsone N and McLaughlin D J | 1996 | IEEE Transactions on Aerospace and Electronic Systems1996，32，4： | 1 |
| 11 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 12 | Experiments on the instabilitiesof a swirling jet显示文摘 | Panda J McLaughlin D K | 1994 | Physics of Fluids1994，6，1： | 1 |
| 13 | Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen显示文摘 | Ajdic D McShan WM McLaughlin RE | 2002 | Proc Natl Acad Sci USA2002，99，14： | 1 |
| 14 | Metals and micronutrients-food safety issues显示文摘 | McLaughlin M J Parker D R Clarke J M | 1999 | Field Crops Research1999，60，： | 1 |
| 15 | Environment and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zeep A | 1993 | Agriculture Ecosystems and Environment1993，46，： | 1 |
| 16 | Mecha- nisms and responses of a single dielectric barrier discharge plas- ma actuator: plasma morphology显示文摘 | Enloe C L McLaughlin T E VanDyken R D | 2004 | AIAA Journal2004，42，3： | 1 |
| 17 | Effect of Long-term with Reclaimed Water on Soils of the Northern Adelaide Plains,South Australian显示文摘 | STEVENS D P MCLAUGHLIN M J SMART M K | 2003 | Australian Journal of Soil Research2003，41，5： | 1 |
| 18 | Calibrating WEPP model parameters for erosion predictionon construction Sites 显示文摘 | MOORE A D MCLAUGHLIN R A MITASOVA H | 2007 | Transactions of the ASABE2007，50，2： | 1 |
| 19 | Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen显示文摘 | Ajdic D McShan WM McLaughlin RE | 2002 | Proc Natl Acad Sci USA2002，99，14： | 1 |
| 20 | Nonpoint Source显示文摘 | Line D E Richar R A McLaughlin | 1997 | Water Envi- ronment Research1997，69，4： | 1 |
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