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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 重症监护室内患者睡眠的自评和护士评估:一项探索性描述研究显示文摘目的:描述ICU患者的睡眠自评报告,检测患者的睡眠自评报告和床旁护士的睡眠评估报告之间的关系;描述患者建议的促进睡眠的对策。方法:对2014-2015年间连续纳入的能进行交流的成年患者,进行了探索性描述研究。患者睡眠情况采用理查兹-坎贝尔(Richards-Campbell)睡眠问卷(评分范围为0~100 mm;得分越高,表明睡眠质量越好)进行自评,同时护士以5级递进形式记录患者睡眠情况,进行评估。要求患者每日描述辅助或妨碍睡眠的因素。研究已获得伦理委员会批准。进行描述性统计分析[中位数(四分位间距)];用Spearman等级相关分析相关关系,用Kruskal-Wallis检验进行差异检验;P<0.05时,认为差异有显著性。结果:151名受试者纳入研究,年龄为60(46~71)岁,ICU停留时间为4(2~9)天,完成了356份睡眠自评报告。自我感知的睡眠质量为46(26~65)mm。睡眠的患者自评和护士评估之间存在中度相关(Spearman等级相关系数为0.39~0.50;P<0.001)。经患者认可的改善睡眠的对策包括适当的止痛和镇静药物,平和舒适的环境,以及集群护理、耳塞等物理措施。结论:患者在ICU期间,完成睡眠自评的中位数为2(1~3)日,表明常规使用自评是可行的。自评报告显示患者的睡眠质量低。在患者自评的多种辅助或妨碍睡眠的因素中,环境因素和影响患者舒适度的因素是最常见的。应实施针对这些因素的干预,以改善患者睡眠状况。 | Leanne M.Aitken Rosalind Elliott Marion Mitchell Chelsea Davis Bonnie Macfarlane Amanda Ullman Krista Wetzig Ashika Datt Sharon McKinley | 2017 | 中国护理管理2017，17，4： | 3 |
| 3 | Kinematic and Contact Stress Analysis of Posterior Malleolus Fractures of the Ankle显示文摘 | Daniel C. Fitzpatrick Jason K. Otto Todd O. McKinley J. Lawrence Marsh Thomas D. Brown | 2004 | Journal of Orthopaedic Trauma2004，，5： | 3 |
| 4 | Use of macroalgae for marine biomass production and CO2 remediation: A review显示文摘 | GAO K MCKINLEY K R | 1994 | J Appl Phycol1994，1，： | 2 |
| 5 | Assessment of anxiety in intensive care patients by using the faces anxiety scale 显示文摘 | McKinley BS Stein-Parbury J Chehelnabis A | 2004 | American Journal of Critical Care2004，13，2： | 1 |
| 6 | Air emissions from foundries: a current survey of literature, suppliers and foundrymen 显示文摘 | McKinley M D Jefcoat I A Herz W J | 1993 | American Foundry Society Transactions1993，101，： | 1 |
| 7 | Priming depletes soil carbon and releases nitrogen in a scrub-oak ecosystem exposed to elevated CO2显示文摘 | Langley J McKinley D Wolf A | 2009 | Soil Biology and Biochemistry2009，41，： | 1 |
| 8 | Lithoautotrophic microbial ecosystems in deep basalt aquifers显示文摘 | Todd O Stevens James P McKinley | 1995 | Science1995，270，： | 1 |
| 9 | Spinal stenosis vs trau- matic spinal cord injury: a rehabilitation outcome comparison 显示文摘 | Mckinley WO Tewksbury MA Mujteba NM | 2002 | J Spi- nal Cord Med2002，25，1： | 1 |
| 10 | Incidence and outcomes of spinal cord injury clinical syndromes显示文摘 | McKinley W Santos K Meade M | 2007 | J Spinal Cord Med2007，30，3： | 1 |
| 11 | Complications of locking plate fixation in com- plex proximal tibia injuries 显示文摘 | Phisitkul P Mckinley TO Nepola JV | 2007 | J Orthop Trauma2007，21，2： | 1 |
| 12 | Opti- mal specimen collection and transport methods for the detection of avian influenza virus and Newcastle disease virus显示文摘 | Spaekman E Pedersen J C McKinley E T | 2013 | BMC veterinary research2013，9，1： | 1 |
| 13 | Miscibility and vis- coelastic properties of acrylic polyhedral oIigomeric siIsesquioxane- poly( methyl methacrylate ) blends 显示文摘 | Kopesky E T Haddad T S McKinley G H | 2005 | Polymer2005，46，3： | 1 |
| 14 | Hydrogen fuel from renewable resources 显示文摘 | BrowneSH NeillDR | 1990 | Energy Sources1990，12，： | 1 |
| 15 | The next generation in shock resuscitation显示文摘 | Moore FA McKinley BA Moore EE | 2004 | Lancet2004，363，9425： | 1 |
| 16 | Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons显示文摘 | MCKINLEY E T BARANOWSKI T C BLAVO D O | 2005 | Brain Res Mol Brain Res2005，141，： | 1 |
| 17 | The ability of clove oil and MS-222 to minimize handling stress in rainbow trout ( Oncorhynchus mykiss Walbaum ) 显示文摘 | WAGNER G N SINGER T D MCKINLEY R S | 2003 | Aquaculture Research2003，34，： | 1 |
| 18 | Organizational decline and innovation: a contingency framework显示文摘 | MONE M A MCKINLEY W BARKER V L | 1998 | The Academy of Management Review1998，23，1： | 1 |
| 19 | Chemical anal-ysis of contaminated soil strengthened by the addition of lime显示文摘 | Mckinley J D Thomas H R Williams K P | 2001 | Engineering Geology2001，60，： | 1 |
| 20 | Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia 显示文摘 | Jacobs T P Kempski O Mckinley D | 1992 | Stroke1992，23，3： | 1 |
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