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| 1 | Practical strategies for modulating foam cell formation and behavior显示文摘Although high density lipoprotein(HDL)-mediated reverse cholesterol transport is crucial to the prevention and reversal of atheroma, a recent meta-analysis makes evident that current pharmaceutical strategies for modulating HDL cholesterol levels lower cardiovascular risk only to the extent that they concurrently decrease low density lipoprotein(LDL) cholesterol. This corresponds well with findings of a recent Mendelian randomization analysis, in which genetic polymorphisms associated with HDL cholesterol but no other known cardiovascular risk factors failed to predict risk for myocardial infarction. Although it is still seems appropriate to search for therapies that could improve the efficiency with which HDL particles induce reverse cholesterol transport, targeting HDL cholesterol levels per se with current measures appears to be futile. Itmay therefore be more promising to promote reverse cholesterol transport with agents that directly target foam cells. Macrophage expression of the cholesterol transport proteins adenosine triphosphate binding cassette transporter A1, adenosine triphosphate binding cassette transporter G1, and scavenger receptor class B member 1 is transcriptionally up-regulated by activated liver X receptors(LXR), whereas nuclear factor(NF)-kappa B antagonizes their expression. Taurine, which inhibits atherogenesis in rodent studies, has just been discovered to act as a weak agonist for LXRalpha. Conversely, it may be possible to oppose NF-kappa B activation in macrophages with a range of measures. Induction of heme oxygenase-1, which can be attained with phase 2 inducer phytochemicals such as lipoic acid and green tea catechins, promotes reverse cholesterol transport in macrophages and inhibits atherogenesis in rodents, likely due to, in large part, NF-kappa B antagonism. Inhibition of macrophage nicotinamide adenine dinucleotide phosphate(NADPH) oxidase activity with the spirulina-derived bilirubin-mimetic phycocyanobilin may also oppose NF-kappa B activation, and salicylic acid similarly should be useful for this purpose. The 5' adenosine monophosphate-activated protein kinase activator berberine promotes macrophage reverse cholesterol transport in cell culture; metformin probably shares this property. Many of these measures could also be expected to promote plaque stability by suppressing foam cell production of inflammatory cytokines and matrix metalloproteinases, and to reduce intimal monocyte infiltration by anti-inflammatory effects on vascular endothelium. Direct targeting of foam cells with agents such as phase 2 inducers, spirulina, salicylate, taurine, and berberine or metformin, may hence have considerable potential for preventing and reversing atheroma, and for preventing the plaque rupture that triggers vascular thrombosis. | Elisabeth Uitz Babak Bahadori Mark F McCarty Mohammed H Moghadasian | 2014 | World Journal of Clinical Cases2014，2，10： | 6 |
| 2 | Field evaluation of soil amendments used in rootzone mixes for golf course putting greens 显示文摘 | WALTZ F C MCCARTY L B | 2005 | International Turfgrass Society Research Journal2005，10，： | 1 |
| 3 | Modelling of anaerobic digestion processes (A discussion of concepts) 显示文摘 | McCARTY P L MOSRY F E | 1991 | Wat Sci Tech1991，24，8： | 1 |
| 4 | The rising global burden of diabetes and its complications: estimates and projections to the year 2010显示文摘 | AMOS A F MCCARTY D J ZIMMET P | 1997 | Diabetic Med1997，14，5： | 1 |
| 5 | A comparison of soluble organic nitrogen in untreated and activated sudge treated wastewaters显示文摘 | PARKIN G F MCCARTY P L | 1981 | Wat Res1981，15，1： | 1 |
| 6 | Oxidative stress therapy for solid tumors-a proposal显示文摘 | Mccarty MF Barroso-Aranda J Contreras F | 2010 | Med Hypotheses2010，74，： | 1 |
| 7 | Mid-Infrared and Near-Infrared Diffuse Reflectance Spectroscopy for Soil Carbon Measurement 显示文摘 | McCarty G W Reeves III J B Reeves V B Follett R F Kimble J M | 2002 | Soil Science Society of America Journal2002，66，： | 1 |
| 8 | A comparison of soluble organic nitrogen in untreated and activated sludge treated wastewaters 显示文摘 | PARKING F MCCARTY P L | 1981 | WatRes1981，15，1： | 1 |
| 9 | Review of advances in cubic boron nitride film synthesis显示文摘 | MIRKARIMI P B MCCARTY K F MEDLIN D L | | 0，，： | 1 |
| 10 | The Effects of Sulfides On Anaerobic Treatment显示文摘 | Lawrence A w McCarty P L Guefin F J A | 1986 | Air&Water Pollution1986，，10： | 1 |
| 11 | Policosanol safely down-regulates HMG-CoA reductase-potential as a component of the Esselstyn regimen 显示文摘 | McCarty M F | 2002 | Med Hypotheses2002，59，3： | 1 |
| 12 | ZD6474,a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase,inhibits orthotopic growth and angiogenesis of gastric cancer显示文摘 | Marya F McCarty Jane Wey | 2004 | Mol Cancer Ther2004，3，9： | 1 |
| 13 | Review of advances in cubic boron nitride film synthesis显示文摘 | Mirkarimi P B McCarty K F Medlin D L | 1997 | Mater Sci Eng1997，21，： | 1 |
| 14 | Advan- cing environmental toxicology through chemical dosim- etry: External exposures versus tissue residues 显示文摘 | McCarty L S Landrum P F Luoma S N | 2011 | In- tegrated Environmental Assessment and Management2011，7，1： | 1 |
| 15 | Using motivational interviewing to promote adherence to antiretroviral medications:a randomized controlled study显示文摘 | DiIorio C McCarty F Resnicow K | 2008 | AIDS Care2008，20，3： | 1 |
| 16 | Preadministration of high-dose salicy- lates, suppressor of NF-kappaB activation, may increase the chemo- sensitvity of many cancers : an example of proapoptotic signal mod- ulation therapy 显示文摘 | McCarty M F Block K I | 2006 | Integr Cancer Ther2006，5，3： | 1 |
| 17 | Pulsed laser deposition of BN onto silicon (100) substrates at 600 ℃ 显示文摘 | Friedmann T A Mccarty K F K laus E J | 1994 | Thin Solid Films1994，237，： | 1 |
| 18 | 显示文摘 | Mirkarimi P B McCarty K F Cardinale G F | 1996 | J Vac Sci Technol1996，14，： | 1 |
| 19 | Mefformin may antagonize Lin28 and/or Lin:28B activity,thereby boosting let-7 levels and antago- nizing cancer progression显示文摘 | MCCARTY M F | 2012 | Med Hypotheses2012，78，： | 1 |
| 20 | Potential utility of natural polyphenols for reversing fat- induced insulin resistance显示文摘 | McCarty M F | 2005 | Med Hypotheses2005，64，3： | 1 |
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