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| 1 | Biliary complications after liver transplantation:current perspectives and future strategies显示文摘Importance:Liver transplantation(LT)is a life-saving therapy for patients with end-stage liver disease and with acute liver failure,and it is associated with excellent outcomes and survival rates at 1 and 5 years.The incidence of biliary complications(BCs)after LT is reported to range from 5%to 20%,most of them occurring in the first three months,although they can occur also several years after transplantation.Objective:The aim of this review is to summarize the available evidences on pathophysiology,risk factors,diagnosis and therapeutic management of BCs after LT.Evidence Review:a literature review was performed of papers on this topic focusing on risk factors,classifications,diagnosis and treatment Findings:Principal risk factors include surgical techniques and donor’s characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non-anastomotic biliary strictures.MRCP is the gold standard both for intra-and extrahepatic BCs,while invasive cholangiography should be restricted for therapeutic uses or when MRCP is equivocal.About treatment,endoscopic techniques are the first line of treatment with success rates of 70-100%.The combined success rate of ERCP and PTBD overcome 90%of cases.Biliary leaks often resolve spontaneously,or with the positioning of a stent in ERCP for major bile leaks Conclusions and Relevance:BCs influence morbidity and mortality after LT,therefore further evidences are needed to identify novel possible risk factors,to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques. | Bianca Magro Matteo Tacelli Alessandra Mazzola Filomena Conti Ciro Celsa | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 12 |
| 2 | Real-world characteristics of hospitalized frail elderly patients with atrial fibrillation: can we improve the current prescription of anticoagulants?显示文摘BackgroundIn 老病人,特别比 80 年旧的那些, atrial 纤维性颤动(AF ) 与击的几乎 25% 增加的风险被联系。有抗凝剂的击预防高度因此被推荐。在这些病人与药方和坚持的更低的率被联系了到抗凝剂治疗的因素的流行几乎不被知道。有或没有 AF,学习是探索老题目的临床的特征的这的目的连续地承认了一个尖锐衰老老人单位,讨论可以减少的因素击预防治疗上的坚持。我们也加亮可能的策略克服障碍调节在 population.MethodsA 的这个片断的口头的抗凝剂的当前的 underuse 回顾的观察学习有或没有进入圣 Gerardo 医院的尖锐衰老老人单位的 AF 在老病人的一个队上被执行( Monza ,意大利 ) .ResultsCompared 到没有 AF 的病人( n = 1216 ),那些与 AF ( n = 403 )有一个更高的 Charlson Comorbidity 索引( 3 对 2 , P < ;0.001 ) ,管理的药的数字(4 对 3, P <0.001 ) ,心失败的率(36.5% 对 12% , P <0.001 ) 并且长期的肾疾病(20.6 对 13.2, P <0.001 ) 。有 AF 的许多病人是脆弱的(54%) 或 pre 脆弱(29%).ConclusionsElderly,有 AF 的病人有影响坚持到传统的抗凝剂治疗的条件的更高的率(维生素 K 对手, VKA ) 。新直接口头的抗凝剂(DOA ) 能帮助克服这个问题。为了规定最适当的 VKA 或 DOA,与最好的功效 / 安全侧面和最高的依从,一个全面衰老老人评价应该总是为 thrombotic 和出血性的风险层化伴随分数。 | Giorgio Annoni Paolo Mazzola | 2016 | Journal of Geriatric Cardiology2016，13，3： | 4 |
| 3 | Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients显示文摘AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF. METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviraltherapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used. RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ 2M H = 4, P < 0.04). In fact, LS ≥ 9.5 was significantly higher in co-infected than in HIV and HCV mono-infected pa-tients (χ 2 = 5, P < 0.03). Also APRI and the FIB-4 index showed more LF in co-infected than in HIV mono-infect-ed patients (P < 0.0001), but not in HCV mono-infected patients. In HIV?HCV co-infected patients, the extent of LS was significantly associated with alcohol intake (P < 0.04) and lower CD4+ cell count (P < 0.02). In HCV pa-tients, LS was correlated with alcohol intake (P < 0.001) and cholesterol levels (P < 0.03). Body mass index, dia-betes, HCV-and HIV-viremia were not significantly cor-related with LS. In addition, 20% of co-infected patients had virologically unsuccessful HAART; in 50% compliance was low, CD4+ levels were < 400 cells/mm 3 and LS was > 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues. CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protective immunological effects of HAART on LF progression outweigh its hepatotoxic effects. | Valentina Li Vecchi Maurizio Soresi Claudia Colomba Giovanni Mazzola Pietro Colletti Maurizio Mineo Paola Di Carlo Emanuele La Spada Giovanni Vizzini Giuseppe Montalto | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 4 | Elucidating the molecular responses of apple rootstock resistant to ARD pathogens:challenges and opportunities for development of genomics-assisted breeding tools显示文摘Apple replant disease(ARD)is a major limitation to the establishment of economically viable orchards on replant sites due to the buildup and long-term survival of pathogen inoculum.Several soilborne necrotrophic fungi and oomycetes are primarily responsible for ARD,and symptoms range from serious inhibition of growth to the death of young trees.Chemical fumigation has been the primary method used for control of ARD,and manipulating soil microbial ecology to reduce pathogen density and aggressiveness is being investigated.To date,innate resistance of apple rootstocks as a means to control this disease has not been carefully explored,partly due to the complex etiology and the difficulty in phenotyping the disease resistance.Molecular defense responses of plant roots to soilborne necrotrophic pathogens are largely elusive,although considerable progress has been achieved using foliar disease systems.Plant defense responses to necrotrophic pathogens consist of several interacting modules and operate as a network.Upon pathogen detection by plants,cellular signals such as the oscillation of Ca^(2+)concentration,reactive oxygen species(ROS)burst and protein kinase activity,lead to plant hormone biosynthesis and signaling.Jasmonic acid(JA)and ethylene(ET)are known to be fundamental to the induction and regulation of defense mechanisms toward invading necrotrophic pathogens.Complicated hormone crosstalk modulates the fine-tuning of transcriptional reprogramming and metabolic redirection,resulting in production of antimicrobial metabolites,enzyme inhibitors and cell wall refortification to restrict further pathogenesis.Transcriptome profiling of apple roots in response to inoculation with Pythium ultimum demonstrated that there is a high degree of conservation regarding the molecular framework of defense responses compared with those observed with foliar tissues.It is conceivable that the timing and intensity of genotype-specific defense responses may lead to different outcomes between rootstocks in response to invasion by necrotrophic pathogens.Elucidation of host defense mechanisms is critical in developing molecular tools for genomics-assisted breeding of resistant apple rootstocks.Due to their perennial nature,use of resistant rootstocks as a component for disease management might offer a durable and cost-effective benefit to tree performance than the standard practice of soil fumigation for control of ARD. | Yanmin Zhu Gennaro Fazio Mark Mazzola | 2014 | Horticulture Research2014，1，1： | 3 |
| 5 | Impact of androgen deprivation therapy on sexua function显示文摘有雄激素剥夺治疗(ADT ) 为被显示的前列腺癌症的许多病人是年轻的并且需要仍然保持性活跃。在如此的病人,性功能上的雄激素治疗的副作用能是在生活的全面质量的严肃的减小的来源。在这张耐心的人口提供适当治疗选择因此是必要的。不过,对待如此的病人是挑战性的,性生理学和 pathophysiology 的内在的机制的理解对最佳的耐心的照顾关键。在这份报纸,我们考察了什么在动物模型在性功能上关于 ADT 的效果被知道,我们也在人和它的治疗在性健康上在 ADT 的效果上提供了详细评论。 | Clarisse R Mazzola John P Mulhall | 2012 | Asian Journal of Andrology2012，14，2： | 3 |
| 6 | Transcriptional regulation of ethylene and jasmonate mediated defense response in apple(Malus domestica)root during Pythium ultimum infection显示文摘Apple replant disease(ARD)is a significant economic restraint to the successful re-establishment of new apple orchards on sites previously planted to the same crop.Pythium ultimum,an oomycete,is a significant component of the ARD pathogen complex.Although ethylene(ET)-and jasmonic acid(JA)-mediated defense responses are intensively studied in the foliar pathosystem,the transferability of this knowledge to the interaction between a perennial root system and soilborne pathogens is unknown.The aim of this study was to test the hypothesis that the ET/JA-mediated defense response is conserved in roots of tree crops in response to infection by P.ultimum.Apple genes with the annotated function of ET/JA biosynthesis,MdERF(ethylene response factor)for signaling transduction and a gene encoding a pathogenesis-related(PR)protein(b-chitinase,the target of ERF)were identified from the apple genome sequences.The transcriptional profiles of these genes during P.ultimum infection and after exogenous ET and/or JA treatment were characterized using qRT-PCR.Several genes showed a 10-to 60-fold upregulation in apple root tissue 24-48 h post inoculation(hpi).Exogenous ET and JA treatment exhibited either a positive or negative influence on expression of ET or JA biosynthesis genes,depending upon gene isoforms and the tissue types,while the expression of MdERF and the PR protein encoding gene was upregulated by both ET and JA treatment.Our data are consistent with the hypothesis that ET/JA-mediated defense pathways are functional in the root system of perennial tree species defending soilborne pathogens. | Sungbong Shin Jingyi Lv Gennaro Fazio Mark Mazzola Yanmin Zhu | 2014 | Horticulture Research2014，1，1： | 2 |
| 7 | Minimally invasive surgery for paediatric inflammatory bowel disease: Personal experience and literature review显示文摘The incidence of paediatric inflammatory bowel disease(PIBD) has dramatically increased in the last 20 years. Although first reported in mid 1970s',diagnostic laparoscopy has started to be routinely adopted in paediatric surgical practice since late 1990s'. Minimally invasive surgery was first limited to diagnostic purposes. After 2002 it was also applied to the radical treatment of PIBD,either Crohn's disease(CD) or Ulcerative colitis. During the last decade minimally invasive approaches to PIBD have gained popularity and have recently became the 'gold standard' for the treatment of such invalidating and troublesome chronic diseases. The authors describe and track the historical evolution of minimally invasive surgery for PIBD and address all available opportunities,including most recent advancements such as robotic surgery,single port approaches and minimally invasive treatment of perianal fistulising CD. A systematic review of all series of PIBD treated with minimally invasive approaches published so far is provided in order to determine the incidence and type of patients' complications reported up to present days. The authors also describe their experience with minimally invasive surgery for PIBD and will report the results of 104 laparoscopic procedures performed in a series of 61 patients between January 2006 and December 2014. | Alessio Pini-Prato Maria Grazia Faticato Arrigo Barabino Serena Arrigo Paolo Gandullia Cinzia Mazzola Nicola Disma Giovanni Montobbio Girolamo Mattioli | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 8 | Liquid-liquid extraction of biomolecules: an overview and update of the main techniques 显示文摘 | Priscila G Mazzola Andre M Lopes Francislene A Hasmann | 2008 | Journal of Chemical Technology and Biotechnology2008，83，2： | 1 |
| 9 | Prodduction lot sizing under setup and worker learning 显示文摘 | Karwan K R Mazzola J B Morey R C | 1988 | Naval Research Logistics1988，35，： | 1 |
| 10 | Infi'ared quenching of conductivity at high electric fields in a bulk, copper- compensated, optically activated switch 显示文摘 | Mazzola M S Schoenbach K H Lakdawala V K | 1990 | IEEE Transac- tions on Electron Devices1990，37，12： | 1 |
| 11 | Trophic Transfer of Trace Elements in an Isotopically Constructed Food Chain From a Semi-enclosed Marine Coastal Area (Stagnone di Marsala, Sicily, Mediterranean)显示文摘 | Salvatrice Vizzini Valentina Costa Cecilia Tramati Paola Gianguzza Antonio Mazzola | 2013 | Archives of Environmental Contamination and Toxicology2013，，4： | 1 |
| 12 | The role of family ownership in international entrepre- neurship : Exploring nonlinear effects 显示文摘 | Sciascia S Mazzola P Astrachan J H Pieper T M | 2012 | Small Bus- iness Economics2012，38，1： | 1 |
| 13 | Activated protein C protection from lung inflammation in endotoxin-induced inj ury显示文摘 | Pirrone F Mazzola SM Pastore C | 2008 | Exp Biol Med2008，233，11： | 1 |
| 14 | Rhinoplasty and endoscopic surgery for functional and inflammatory nasal/sinus disorders显示文摘 | Mazzola RF Felisati G | | 0，，06： | 1 |
| 15 | Beneficial influence of platelets on antibiotic efficacy in an in vitro model of Staphylococcus aureus-induced endocarditis显示文摘 | Mercier RC Dietz RM Mazzola JL | 2004 | Antimicrob Agents Chemother2004，48，7： | 1 |
| 16 | Long -tem follow-up of patients with anti Hbe/HBV DNA-positive chronic hepatitis B treated for 12months with lam ivudine显示文摘 | Santantonio T Mazzola M Iacovazzi T | 2000 | Jhepatol2000，32，2： | 1 |
| 17 | Postnatal follow-up of infants born to mothers with certain toxoplasmagon-dii infection : evaluation of prenatal management显示文摘 | Dicarlo P Mazzola A Roraano A | 2005 | In-fez Med2005，13，2： | 1 |
| 18 | A strategic framework for finn networks in manufacturing industry: An empirical survey 显示文摘 | MAZZOLA E BRUCCOLERI M PERRONE G | 2009 | CIRP Annals - Manufacturing Technology2009，10，： | 1 |
| 19 | Multiproduct production planning in the presence of work-force learning 显示文摘 | Mazzola J B Neebe A W Rump C M | 1998 | European Journal of Operational Research1998，106，12： | 1 |
| 20 | Rhinoplasty and endoscopic surgery for functional and inflammatory nasal/sinus disor- ders显示文摘 | Mazzola RF Felisati G | 2005 | Plast Reconstr Surg2005，115，3： | 1 |
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