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| 1 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 2 | Microbial diversity of traditional Vietnamese alcohol fermentation starters ( banh men ) as determined by PCR-mediated DGGE显示文摘 | Vu Nguyen Thanh Le Thuy Mai Duong Anh Tuan | 2008 | International Journal of Food Microbiology2008，，2： | 2 |
| 3 | The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat显示文摘 | Phuong Mai Le Ali Benhaddou-Andaloussi Aziz Elimadi Abdellatif Settaf Yahia Cherrah Pierre S. Haddad | 2004 | Journal of Ethnopharmacology2004，，2： | 2 |
| 4 | DIAGNOSING BLADDER OUTLET OBSTRUCTION IN WOMEN显示文摘 | VICTOR W. NITTI LE MAI TU JORDAN GITLIN | 1999 | The Journal of Urology1999，，5： | 1 |
| 5 | Preparation and antitumor - promoting activity of curcuminencapsulated by 1,3-beta-glucan isolated from Vietnam medicinalmushroom Hericium erinaceum显示文摘 | Le Mai Huong Ha Phuong Thu Nguyen Thi Bich Thuy al | 2011 | Chemistry Letters2011，40，8： | 1 |
| 6 | Lowcomplexity maximum-likelihood decoder for four-transmit-antenna quasi-orthogonal spacetime block code 显示文摘 | Minh-Tuan Le Van-Su Pham Linh Mai Giwan Yoon | 2005 | IEEE Trans on communications2005，53，11： | 1 |
| 7 | Modified Foxp3 mRNA protects against asthma through an IL-10 dependent mechanism显示文摘 | Mays LE Ammon Treiber S Mothes B | 2013 | J Clin Invest2013，123，3： | 1 |
| 8 | Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism显示文摘 | Mays LE Ammon-Treiber S Mothes B | 2013 | J Clin Invest2013，123，3： | 1 |
| 9 | Effect of community-based nutrition education intervention on calcium intake and bone mass in postmenopausal Vietnamese women 显示文摘 | Hien VT Khan NC Mai le B | 2009 | Public Health Nutr2009，12，5： | 1 |
| 10 | Activities of selected digestive enzymes during larval development of large yellow croaker ( Pseudosciaena crocea )显示文摘 | Hongming Ma Chantal Cahu José Zambonino Hairui Yu Qingyuan Duan Marie-Madeleine Le Gall Kangsen Mai | 2004 | Aquaculture2004，，1： | 1 |
| 11 | The 2003 heat wave in France:Dangerous climate change here and now显示文摘 | Poumadere M Mays C Le Mer S | 2005 | Risk Analysis2005，25，6： | 1 |
| 12 | 法国饲料玉米青贮及饲养技术显示文摘Ⅰ.青贮玉米的演变 A.面积 1972年为580000公顷,1973年620000公顷,1974年780000公顷,1975年810000公顷,1976年900000公顷,1977年10500000公顷。 B.多种利用 青贮饲料玉米作为动物饲料,是一种十分柔软的食物。 ——收获的籽粒玉米和粉碎后的青贮湿饲料,很多被用作猪饲料。 ——收获的玉米穗,粉碎后的同样可以进行青贮。 ——收获的玉米和整株玉米青贮,可作为奶牛、公牛及幼牛的食物,也可作羊的饲料。 | Le MAIS FOURRAGE 王广智 | 1996 | 古今农业1996，，4： | 1 |
| 13 | Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism显示文摘 | Mays LE Ammon-Treiber S Mothes B | 2013 | J Clin Invest2013，123，3： | 1 |
| 14 | The 2003 heat wave in France: dangerous climate change here and now显示文摘 | Poumadere M Mays C Le Mer S | 2005 | Risk Anal2005，25，： | 1 |
| 15 | A Low Complexity Branch-and-bound-based Decoder for V-BLAST Systems with PSK Signals显示文摘 | Le M T Pham V S Mai L | 2009 | Signal Processing2009，89，2： | 1 |
| 16 | The 2003 Heat Wave in France: Dangerous Climate Change Here and Now 显示文摘 | Marc Poumad ere Claire Mays Sophie Le Mer | 2005 | Risk Analysis2005，25，： | 1 |
| 17 | Growth Determinants for H5N1 Influenza Vaccine Seed Viruses in MDCK Cells 显示文摘 | Shin Murakami Taisuke Horimoto Le Quynh Mai | 2008 | Virology2008，82，10： | 1 |
| 18 | Isolation of drug-resistant H5N1 virus显示文摘 | Q Mai Le Maki Kiso Kazuhiko Someya | 2005 | Nature2005，437，： | 1 |
| 19 | Mi- crobial diversity of traditional Vietnamese alcohol fermenta- tion starters (banh men)as determined by PCR-mediated DGGE 显示文摘 | Vu Nguyen Thanh Le Thuy Mai Duong Anh Tuan | 2008 | International Journal of Food Microbiology2008，，： | 1 |
| 20 | Some features of seismic activity in Vietnam显示文摘 | Cao Dinh Trieu Nguyen Huu Tuyen Pham Nam Hung Le Van Dung Mai Xuan Bach Giuliano F Pauza A Peresan F Vaccari and F Romanelli | | 0，，03： | 1 |
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