| 1 | Sc(OTf)_(3)-catalyzed synthesis of polysubstituted furans from acylacetonitriles and renewable acetol显示文摘A[3+2]cyclization reaction of acylacetonitriles and hydroxyacetone was developed by using Sc(OTf)_(3)as a catalyst to synthesize some furan derivatives.Bifunctional C2-based acetals,such asα-bromoacetaldehyde acetal,1,4-dithiane-2,5-diol and glycolaldehyde diethyl acetal,also reacted readily as alternative counterpart reagents to acylacetonitriles.The established reactions can be used to synthesize a well-known fungicide,fenfuram.Antifungal activity investigation against four common plant funguses indicated that some of the obtained furan products furnish general and high biological activities. | Wenbo Huang Fang Liu Kaimei Wang Alexander Sidorenko Maxim Bei Zhigang Zhang Wei Fang Minghao Li Yanlong Gu Shaoyong Ke | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
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