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| 1 | Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells显示文摘In the last years,several studies have been focused on elucidate the role of tumor microenvironment(TME)in cancer development and progression.Within TME,cells from adaptive and innate immune system are one of the main abundant components.The dynamic interactions between immune and cancer cells lead to the activation of complex molecular mechanisms that sustain tumor growth.This important cross-talk has been elucidate for several kind of tumors and occurs also in patients with liver cancer,such as hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA).Liver is well-known to be an important immunological organ with unique microenvironment.Here,in normal conditions,the rich immune-infiltrating cells cooperate with non-parenchymal cells,such as liver sinusoidal endothelial cells and Kupffer cells,favoring self-tolerance against gut antigens.The presence of underling liver immunosuppressive microenvironment highlights the importance to dissect the interaction between HCC and iCCA cells with immune infiltrating cells,in order to understand how this cross-talk promotes tumor growth.Deeper attention is,in fact,focused on immune-based therapy for these tumors,as promising approach to counteract the intrinsic anti-tumor activity of this microenvironment.In this review,we will examine the key pathways underlying TME cell-cell communications,with deeper focus on the role of natural killer cells in primary liver tumors,such as HCC and iCCA,as new opportunities for immune-based therapeutic strategies. | Michela Anna Polidoro Joanna Mikulak Valentina Cazzetta Ana Lleo Domenico Mavilio Guido Torzilli Matteo Donadon | 2020 | World Journal of Gastroenterology2020，26，33： | 4 |
| 2 | Pathologic natural killer cell subset redistribution in HIV-1 infection: new in- sights in pathophysiology and clinical outcomes显示文摘 | Brunetta E Hudspeth KL Mavilio D | 2010 | J Leu/c Biol2010，88，6： | 1 |
| 3 | Gene therapy of inherited skin adhesion disorders:a critical overview显示文摘 | De Luca M Pellegrini G Mavilio F | 2009 | Br J Dermatol2009，161，1： | 1 |
| 4 | ColTection of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells显示文摘 | Mavilio F Pellegrini G Ferrari S | 2006 | Nat Med2006，12，12： | 1 |
| 5 | Multiple HLA-class Ⅰ-specific inhibitory NK receptor expression and IL-4/IL-5 production by CD8 ±T-cell clones显示文摘 | MARIA-A MAVILIO COSTA P DIGNETTI FOGLI M MINGARI | 2000 | Immunology Letters2000，72，3： | 1 |
| 6 | Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells显示文摘 | Mavilio F Pellegrini G Ferrari S | 2006 | Nat Med2006，12，12： | 1 |
| 7 | Topical 5-aminolevulinic acid and photodynamic therapy in dermatology:a minireview显示文摘 | Campolni P Mavilio L | 2001 | J Chemother2001，13，： | 1 |
| 8 | Reversible posterior leucoencephalopathy syndrome in systemic lupus and vasculitis 显示文摘 | Primavera A Audenino D Mavilio N | 2001 | Ann Rheum Dis2001，60，5： | 1 |
| 9 | The future of gene therapy显示文摘 | CAVAZZANA-CALVO M THRASHER A MAVILIO F | 2004 | Nature2004，427，6977： | 1 |
| 10 | The future of gene therapy显示文摘 | Cavazzana-Calvo M Thrasher A Mavilio F | 2004 | Nature2004，427，6977： | 1 |
| 11 | The future of gene therapy显示文摘 | THRASHER A MAVILIO F | 2004 | Nature2004，427，6977： | 1 |
| 12 | Failure to correct murine muscular dystrophy显示文摘 | Ferrari G Stornaiuolo A Mavilio F | 2001 | Nature2001，411，6841： | 1 |
| 13 | IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity显示文摘 | Fabrizi M Marchetti V Mavilio M | 2014 | Diabetes2014，63，6： | 1 |
| 14 | Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional cor- relates 显示文摘 | Mavilio D Benjamin J Daucher M etal | 2003 | Proc Natl Acad Sci U S A2003，100，15： | 1 |
| 15 | The future of gene therapy 显示文摘 | CAVAZZANACALVO M THRASHIER A MAVILIO F | 2004 | Nature2004，427，6977： | 1 |
| 16 | Inhibition of retinoic acid-induced activation of 3'human HOXB genes by antisense oligo-nucleotides affects sequential activation of genes located upstream in the four HOX clusters显示文摘 | Faiella A Zappavigna V Mavilio F | 1994 | Proc Nat Acad Sci USA1994，91，： | 1 |
| 17 | Activation of four homeobox gene clusters in human embryonal carcimoma cells induced to differentiate by retinolc acld显示文摘 | Mavilio F Simeone A Boncinelli E | 1988 | Differentiation1988，37，： | 1 |
| 18 | Recovery of third nerve palsy after endovascular packing of internal carotid-posterior communicating artery aneurysms 显示文摘 | Mavilio N Pisani R Rivano C | 2000 | Intervent Neuroradiol2000，6，： | 1 |
| 19 | Spontaneous coro- nary dissection complicating unstable coronary plaque in youngwomen with acute coronary syndrome:Case reports 显示文摘 | Brunetti ND Pellegrino PL Mavilio G | 2007 | Int JCardiol2007，115，1： | 1 |
| 20 | Correction of iunctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells显示文摘 | Mavilio F Pellgrini G Stefano F | 2006 | Nat Med2006，12，12： | 1 |
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