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| 1 | Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A recep- tom显示文摘 | MANIYKTA P K ANGELO O R MATHEUS M R | 2004 | Nemvscience Letters2004，355，： | 1 |
| 2 | Thermal decomposition of wood:Influence of wood components and cellulose crystallite size显示文摘 | Matheus P Ademir J Zattera M M | 2012 | Bioresource Technology2012，，109： | 1 |
| 3 | Nanoparticle-induced light scattering for improved per- formance of quantum-well solar cells 显示文摘 | DERKACS D CHEN W V MATHEU P M | 2008 | Appl Phys Lett2008，93，09： | 1 |
| 4 | Active and semi-active control of structures under seismic excitation显示文摘 | Singh M P Matheu E E Suarez L E | | Earthquake Engineering and Structural Dynamics0，26，2： | 1 |
| 5 | Active and semi-active control of structures under seismic excitation显示文摘 | Singh M P Matheu E E Suarez L E | 1997 | Earthquake Engineering and Structural Dynamics1997，26，2： | 1 |
| 6 | Systems for knowledge discovery in database显示文摘 | Matheus C M Chan P K Piatestsky-Shapiro G | 1993 | IEEE Trans Knowledge and Data Engineering1993，5，6： | 1 |
| 7 | A Response Spectrum Approach for Seismic Performance Evaluation of Actively Controlled Structures 显示文摘 | Singh M P Singh S Matheu E E | 2000 | Earthquake Engineering and Structural Dynamics2000，29，7： | 1 |
| 8 | Nano particle-induced light scattering for improved performance of quantum-well solar cells 显示文摘 | DERKACS D CHEN W V MATHEU P M | 2008 | Appl Phys Lett2008，93，9： | 1 |
| 9 | Nanoparticle-induced light scttering for improved performace of quantum well solar cells 显示文摘 | DERKACS D CHEN W V MATHEU P M | 2008 | Appl Phys Lett2008，93，9： | 1 |
| 10 | Seismic response of structural frameworks with flexible connections显示文摘 | SUAREZ L E SINGH M P MATHEU E E | 1996 | Computers and Structures1996，58，1： | 1 |
| 11 | Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis显示文摘 | Greenberg M L Weinger J G Matheu M P | 2014 | Proc Natl Acad Sci U S A2014，111，22： | 1 |
| 12 | A Hybrid Approach to Closed - Loop Directional Drilling Control Using Rotary Steer- able Systems显示文摘 | Matheus J Ignova M Hornblower P | 2014 | Automatic Control in Offshore Oil & Gas Production2014，1，1： | 1 |
| 13 | Imagingregulatory T cell dynamics and CTLA4 -mediated suppressionof T cell priming显示文摘 | MATHEU M P OTHY S GREENBERG M L | 2015 | Nature Communications2015，6，： | 1 |
| 14 | Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease显示文摘BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in animals.METHODS Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were obtained.RESULTS All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop HCC.Comparing animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the HCC-group.The opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-protein.Comparing with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P<0.05).Carm1 was lower in HCC compared to RIF(P<0.05).Hepatic expression of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(P<0.05).Expression of p62/SQSTM1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P<0.05).miR-26b was lower in HCC compared to RIF,and the inverse was observed for miR-224(P<0.05).There was no difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis through epigenetic modulation in a rat model of MASLD-HCC. | Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva | 2024 | World Journal of Hepatology2024，16，1： | 0 |
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