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| 1 | Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes显示文摘AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran. METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was ≥ 40 U/L, it was rechecked twice within 6 mo. Those with ≥ 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology. RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively]. CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran. | Raika Jamali Mahmoodreza Khonsari Shahin Merat Masoud Khoshnia Elham Jafari Alireza Bahram Kalhori Hassan Abolghasemi Sedighe Amini Mahtab Maghsoudlu Mohammad Reza Deyhim Houri Rezvan Akram Pourshams | 2008 | World Journal of Gastroenterology2008，14，18： | 7 |
| 2 | Radiation-induced inflammation and autoimmune diseases显示文摘Currently,ionizing radiation(IR)plays a key role in the agricultural and medical industry,while accidental exposure resulting from leakage of radioactive sources or radiological terrorism is a serious concern.Exposure to IR has various detrimental effects on normal tissues.Although an increased risk of carcinogenesis is the best-known long-term consequence of IR,evidence has shown that other diseases,particularly diseases related to inflammation,are common disorders among irradiated people.Autoimmune disorders are among the various types of immune diseases that have been investigated among exposed people.Thyroid diseases and diabetes are two autoimmune diseases potentially induced by IR.However,the precise mechanisms of IR-induced thyroid diseases and diabetes remain to be elucidated,and several studies have shown that chronic increased levels of inflammatory cytokines after exposure play a pivotal role.Thus,cytokines,including interleukin-1(IL-1),tumor necrosis factor(TNF-α)and interferon gamma(IFN-α),play a key role in chronic oxidative damage following exposure to IR.Additionally,these cytokines change the secretion of insulin and thyroid-stimulating hormone(TSH).It is likely that the management of inflammation and oxidative damage is one of the best strategies for the amelioration of these diseases after a radiological or nuclear disaster.In the present study,we reviewed the evidence of radiation-induced diabetes and thyroid diseases,as well as the potential roles of inflammatory responses.In addition,we proposed that the mitigation of inflammatory and oxidative damage markers after exposure to IR may reduce the incidence of these diseases among individuals exposed to radiation. | Rasoul Yahyapour Peyman Amini Saeed Rezapour Mohsen Cheki Abolhasan Rezaeyan Bagher Farhood Dheyauldeen Shabeeb Ahmed Eleojo Musa Hengameh Fallah Masoud Najafi | 2018 | Military Medical Research2018，5，1： | 7 |
| 3 | Are body mass index and waist circumference significant predictors of diabetes and prediabetes risk: Results from a population based cohort study显示文摘AIM To determine the predictive role of body mass index(BMI) and waist circumference(WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013(n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined. Multivariable logistic regression analysis was used for determining the risk of diabetes and prediabetes considering important potential confounding variables. Receiver operatingcharacteristic curve analysis was conducted to determine the best cut of values of BMI and WC for diabetes and prediabetes. RESULTS At 2013, among participants who had complete data, 45 and 307 people were diabetic and prediabetic, respectively. In final fully adjusted model, BMI value was a significant predictor of diabetes(RR = 1.39, 95%CI: 1.06-1.82 and AUC = 0.68, 95%CI: 0.59-0.75; P < 0.001) however not a significant risk factor for prediabetes. Also, WC was a significant predictor for diabetes(RR = 1.2, 95%CI: 1.05-1.38 and AUC = 0.67, 95%CI: 0.6-0.75) but not significant risk factor for prediabetes. Similar results were observed in both genders.CONCLUSION General and abdominal obesity are significant risk factors for diabetes in future. | Fahimeh Haghighatdoost Masoud Amini Awat Feizi Bijan Iraj | 2017 | World Journal of Diabetes2017，8，7： | 4 |
| 4 | Different metabolic/obesity phenotypes are differentially associated with development of prediabetes in adults: Results from a 14-year cohort study显示文摘BACKGROUND The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. AIM To examine the association of baseline metabolic/obesity phenotypes and their changes over time with the risk of prediabetes development. METHODS In a population-based cohort study, 1741 adults (aged > 19 years) with normal blood glucose were followed for 14 years. Anthropometric and biochemical measures were evaluated regularly during the follow-up period. According to body mass index and metabolic health status, participants were categorized into four groups: Metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW) and metabolically unhealthy obese (MUO). Multivariable Cox regression analysis was used to measure the risk of prediabetes according to the baseline metabolic/obesity phenotype and their changes during the follow-up. RESULTS In the whole population with a mean (95CCI for mean) follow up duration of 12.7 years (12.6-12.9), all three MUNW, MHO, MUO groups were at higher risk for developing prediabetes compared to the MHNW group (P = 0.022). The MUNW group had the highest risk for developing prediabetes (hazard ratio (HR): 3.84, 95%CI: 1.20, 12.27). In stratified analysis by sex, no significant association was found in men, while women in the MUNW group were at the greatest risk for prediabetes (HR: 6.74, 95%CI: 1.53, 29.66). Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with an increased risk of prediabetes (HR > 1;P < 0.05). CONCLUSION Our findings indicate that MHO is not a high risk, unless it transforms into MUO over time. However, people in the MUNW group have the greatest risk for developing prediabetes, and therefore, they should be screened and treated. | Fahimeh Haghighatdoost Masoud Amini Ashraf Aminorroaya Majid Abyar Awat Feizi | 2019 | World Journal of Diabetes2019，10，6： | 2 |
| 5 | Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran显示文摘 | Ammar H. Keshteli Mahin Hashemipour Mansour Siavash Masoud Amini | 2009 | Biological Trace Element Research (-)2009，，1： | 1 |
| 6 | Evaluation of direct intramural injection to the bladder wall as a method for developing orthotopic tumor models显示文摘Background:Bladder cancer poses a great burden on society and its high rate of recurrence and treatment failure necessitates use of appropriate animal models to study its pathogenesis and test novel treatments.Orthotopic models are superior to other types since they provide a normal microenvironment.Four methods are described for developing bladder cancer models inside the animal’s bladder.Direct intramural injection is one of these methods and is widely used.However,its efficacy in model development has not yet been studied.We aimed to evaluate the efficacy and success rate of the direct intramural injection method of developing an orthotopic model for the study of bladder cancer.Method:Tumor cell lines were prepared in four microtubes.Aliquots of 200×10^(3) cells were injected through a 27 gauge needle into the ventral wall of the bladders of 4male and 4 female BALB/c mice following a midline 1 cm laparotomy incision.In addition,1 million cells from each microtube were injected into the flanks of control mice.To prevent infection and alleviate pain,5 mg/kg enrofloxacin and 2.5 mg/kg flunixin meglumine,respectively,were injected subcutaneously.Results:Tumors formed in all mice,resulting in 100% take rate and zero post-operation mortality.Surgery time was≤15 min per mouse.In two mice,tumors were found in the peritoneal space as well.Conclusion:Direct intramural injection is a rapid,reliable,and reproducible method for developing orthotopic models of bladder cancer.It can be done on both male and female mice and only requires readily available surgical tools.However,needle track can result in cell spillage and peritoneal tumors. | Masoud Bitaraf Samad Muhammadnejad Ashkan Azimzadeh Saman Behboodi Tanourlouee Erfan Amini Masoumeh Majidi Zolbin Abdol-Mohammad Kajbafzadeh | 2022 | Animal Models and Experimental Medicine2022，5，6： | 1 |
| 7 | Dye removal from colored textile wastewaterusing acrylic grafted nanomembrane显示文摘 | Masoud Amini Mokhtar Arami Niyaz Mohammad Mah-moodi | 2011 | Desalination2011，267，1： | 1 |
| 8 | Severity of the metabolic syndrome as a predictor of prediabetes and type 2 diabetes in first degree relatives of type 2 diabetic patients:A 15-year prospective cohort study显示文摘BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A strong correlation between severity of metabolic syndrome(MetS)and HbA1c,fasting insulin and insulin resistance has been reported.Accordingly,the MetS severity score(or MestS Zscore)can potentially be used to predict the risk of T2DM progression over time.AIM To evaluate the association the of MestS Z-score in first degree relatives(FDRs)of T2DM with the risk of prediabetes and type 2 diabetes in future.METHODS A prospective open cohort study was conducted between 2003-2018.At baseline,the sample comprised of 1766 FDRs of patients with T2DM who had a normal glucose tolerance test.Relative risk(RR)and 95%confidence interval were calculated based on logistic regression.The receiver-operator characteristic analysis and area under the curve based on MetS Z-score were used to evaluate the risk of prediabetes and diabetes among the FDR population.RESULTS Baseline MetS Z-scores were associated with the its latest values(P<0.0001).Compared with individuals who were T2DM free at the end of follow up,those who developed T2DM had higher MetS Z-score at baseline(P<0.001).In multivariable logistic regression analyses for every unit elevation in MetS Z-score at the baseline,the RR for developing future T2DM and prediabetes was(RR=1.94,RR=3.84),(RR=1.5,RR=2.17)in total population and female group,respectively(P<0.05).The associations remained significant after adjusting the potential confounding variables.A cut off value of 0.97 and 0.94 was defined in the receiver-operator characteristic curve based on the MetS Z-score for differentiating female patients with diabetes and prediabetes from the normal population,respectively.CONCLUSION The MetS Z-score was associated with an increased risk of future T2DM.Appropriate interventions at earlier stages for preventing and attenuating MetS effects may be considered as an effective strategy for FDR as at-risk population. | Rokhsareh Meamar Masoud Amini Ashraf Aminorroaya Maryam Nasri Majid Abyar Awat Feizi | 2020 | World Journal of Diabetes2020，11，5： | 1 |
| 9 | Nationwide survey of prevalence and risk factors of prehypertension and hypertension in Iranian adults显示文摘 | Mohsen Janghorbani Masoud Amini Mohammad Mehdi Gouya Alireza Delavari Siamak Alikhani Alireza Mahdavi | 2008 | Journal of Hypertension2008，，3： | 1 |
| 10 | Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran显示文摘 | Ammar H. Keshteli Mahin Hashemipour Mansour Siavash Masoud Amini | 2009 | Biological Trace Element Research (-)2009，，1： | 1 |
| 11 | 中间层成分对GTD-111/IN-718高温合金在瞬时液相连接过程中显微组织和力学性能的影响显示文摘研究使用不同的中间层瞬时液相连接两种异种高温合金的适用性。在1100℃、不同时间下瞬时液相连接GTD-111/IN-718体系,研究BNi-2、BNi-3和BNi-9三种类型的中间层对该体系显微组织和力学性能的影响。采用场发射扫描电子显微镜和能量色散光谱技术,研究接头区域的成分变化和显微组织。结果表明,非热凝固区Ni_(3)B的形成受B含量控制,相应地,Ni_(3)Si的形貌受Si含量控制。Cr含量可能会阻碍B从中间层向母材迁移,非热凝固区内Cr B的形成主要受Cr含量的影响。硼化物如镍或铬硼化物基体的形成,使共晶化合物具有高的显微硬度。与使用BNi-3和BNi-2中间层的合金接头相比,等温凝固结束后,使用BNi-9中间层的合金接头其剪切强度更低,这可能与金属焊料成分中不含Si和BNi-9中含Cr有关。 | Ali IZADI GHAHFEROKHI Masoud KASIRI-ASGARANI Kamran AMINI Mahdi RAFIEI Reza EBRAHIMI-KAHRIZSANGI | 2022 | Transactions of Nonferrous Metals Society of China2022，32，3： | 0 |
| 12 | Microorganism-derived biological macromolecules for tissue engineering显示文摘According to literature,certain microorganism productions mediate biological effects.However,their beneficial characteristics remain unclear.Nowadays,scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative medicine.The present review aims to introduce microorganism-derived biological macromolecules,such as pullulan,alginate,dextran,curdlan,and hyaluronic acid,and their available sources for tissue engineering.Growing evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological applications.These natural-based materials are attractive in pharmaceutical,regenerative medicine,and biomedical applications.This study provides a detailed overview of natural-based biomaterials,their chemical and physical properties,and new directions for future research and therapeutic applications. | Naser Amini Peiman Brouki Milan Vahid Hosseinpour Sarmadi Bahareh Derakhshanmehr Ahmad Hivechi Fateme Khodaei Masoud Hamidi Sara Ashraf Ghazaleh Larijani Alireza Rezapour | 2022 | Frontiers of Medicine2022，16，3： | 0 |
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