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您的检索式：作者名="Martine Simonelig"
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| 1 | The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm显示文摘Piwi-interacting RNAs(piRNAs)and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs.In Drosophila,piRNAs bound to the PIWI protein Aubergine(Aub)are transferred maternally to the embryo and regulate maternal mRNA stability through two opposite roles.They target mRNAs by incomplete base pairing,leading to their destabilization in the soma and stabilization in the germ plasm.Here,we report a function of Aub in translation.Aub is required for translational activation of nanos mRNA,a key determinant of the germ plasm.Aub physically interacts with the poly(A)-binding protein(PABP)and the translation initiation factor elF3.Polysome gradient profiling reveals the role of Aub at the initiation step of translation.In the germ plasm,PABP and elF3d assemble in foci that surround Aub-containing germ granules,and Aub acts with elF3d to promote nanos translation.These results identify translational activation as a new mode of mRNA regulation by Aub,highlighting the versatility of PIWI proteins in mRNA regulation. | Anne Ramat Maria-Rosa Garcia-Silva Camille Jahan Rima Nait-Saidi Jeremy Dufourt Celine Garret Aymeric Chartier Julie Cremaschi Vipul Patel Mathilde Decourcelle Amandine Bastide Francois Juge Martine Simonelig | 2020 | Cell Research2020，30，5： | 1 |
| 2 | PABPN1 shuts down alternative poly(A) sites显示文摘 | Martine Simonelig | 2012 | Cell Research2012，22，10： | 1 |
| 3 | piRNAs, master regulators of gene expression显示文摘交往 Piwi RNA (piRNAs ) 在 germline 在 transposable 元素的压抑有主要功能;另外,他们被建议了调整基因表示。在房间研究的最近的研究在老鼠精子形式期间在巨大的 mRNA 腐烂为 piRNAs 揭示一个一般角色,增强 piRNAs 的这新兴的功能。 | Martine Simonelig | 2014 | Cell Research2014，24，7： | 0 |
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