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您的检索式：作者名="Martin W.KING"
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| 1 | Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment显示文摘Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery disease.However,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy effects.Here,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease application.The cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite yarns.Interlacing points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance.The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process.In addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids.The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent.In both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up.The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro.It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS.Moreover,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months. | Fan Zhao Jing Sun Wen Xue Fujun Wang Martin W.King Chenglong Yu Yongjie Jiao Kun Sun Lu Wang | 2021 | Bioactive Materials2021，6，9： | 3 |
| 2 | 人工血管与药物显示文摘人工血管的成功取决于多种因素,包括材料的化学、物理性质和结构设计。本文通过回顾人工血管的历史发展和作者的一些工作,在一定程度上总结过去的经验,希望对人工血管的进一步发展能够有所帮助。 | 张泽 Robert GUIDOIN Yvan DOUVILLE Martin W.KING | 2010 | 药物分析杂志2010，30，7： | 1 |
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