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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Cumulative exposure to tamoxifen:DNA ad-ducts and liver cancer in the rat显示文摘 | Carthew P Lee PN Edwards RE Heydon RT Nolan BM Martin EA | 2001 | Arch Toxicol2001，75，6： | 1 |
| 3 | Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction显示文摘 | Martins PN Reutzel-Selke A Jurisch A | 2006 | Transplantation2006，82，7： | 1 |
| 4 | Renal Vein Entrapment Syndrome Frequency and Diagnosis:a Lesson in Conservatism显示文摘 | Wolfish NM Mclaine PN Martin D | 1986 | Clin Nephrol1986，26，2： | 1 |
| 5 | Learning curve, surgical results and operative complications for kidney transplantation in mice显示文摘 | Martins PN | 2006 | Microsurgery2006，26，8： | 1 |
| 6 | Microsurgical techniques for experimental kidney transplantation and general guidelines to establish studies about transplantation immunology显示文摘 | Filatenkov A | 2003 | Aeta Cir Bras2003，18，2： | 1 |
| 7 | Sexual behavior patterns of methamphetamine-using gay and bisexual men显示文摘 | Halkitis PN Shrem MT Martin FW | 2005 | Subst Use Mis- use2005，40，5： | 1 |
| 8 | Renal vein entrapment syndrome: frequency and diagnosis :a lesson in conservation 显示文摘 | Wolfish NM Mclaine PN Martin D | 1986 | Clin Nephrol1986，26，： | 1 |
| 9 | Induction of carbon monoxide in the donor reduces graft immunoge- nicity and chronic graft deterioration 显示文摘 | Martins PN Reuzel-Selke A Jurisch A | 2005 | Transplant Proc2005，37，1： | 1 |
| 10 | Technique of kidney transplantation in mice with anti-reflux urinary reconstruction显示文摘 | Martins PN | 2006 | Int BrazJ Urol2006，32，6： | 1 |
| 11 | Induction of heme oxygenase- 1 in the donor reduces graft immunogenicity显示文摘 | Martins PN Kessler H Jurisch A | 2005 | Transplant Proc2005，37，1： | 1 |
| 12 | Detachable cuffs for sutureless microvast-u-lar anastomosis显示文摘 | Martins PN Theruvath TP | 2007 | Microsurgery2007，27，8： | 1 |
| 13 | Rodent models of partial hepatectomies显示文摘 | Martins PN Theruvath TP Neuhaus P | | 0，，： | 1 |
| 14 | Woman with poor response to IVF have lowered circulating gonadotrophin surge-attenuating foctor bioactivity during spontaneous cycle显示文摘 | Martine F Barri PN Coroleu B | 2002 | Hum Reprod2002，17，3： | 1 |
| 15 | Hepatic lobectomy and segmentec- tomy models using microsurgical techniques显示文摘 | Martins PN Neuhaus P | 2008 | Microsurgery2008，28，： | 1 |
| 16 | Induction of carbon monoxide in the donor reduces graft immunogenicity and chronic graft deterioration显示文摘 | Martins PN Reuzel-Selke A Jurisch A | 2005 | Transplant Proc2005，37，1： | 1 |
| 17 | Rodent models of partial hepatectomies显示文摘 | Martins PN Theruvath TP Neuhaus P | 2008 | Liver Int2008，28，： | 1 |
| 18 | Induction of heme oxygenase-1 in the donor reduces graft immuno-genicity显示文摘 | Martins PN Kessler H Jurisch A | 2005 | Transplant Proc2005，37，1： | 1 |
| 19 | Renal vein entrapment syndrome: frequency and diagnosis 显示文摘 | Wolfish NM Mclaine PN Martin D | 1986 | Clin Nephrol1986，2692，： | 1 |
| 20 | Renal vein entrapment syndrome:frequency and diagnosis, a lessou in conservatism 显示文摘 | WOLFISH NM MCLAINE PN MARTIN D | 1986 | Clin Nephrol1986，26，2： | 1 |
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