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| 1 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 2 | Comparison of brightness temperatures observed from ground-based microwave radiome ters during TUC显示文摘 | Cimini D T J Hewison L Martin | 2006 | Meteorologische Zeitschrift2006，15，1： | 1 |
| 3 | Temperature and humidity profile retrievals from ground-based microwave radi-ometers during TUC显示文摘 | Cimini D Hewison T J Martin T | | 0，，05： | 1 |
| 4 | An update on Vitamin D and human immunity显示文摘 | Martin Hewison | 2012 | Clin Endocrinol (Oxf)2012，76，3： | 1 |
| 5 | Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25‐dihydroxyvitamin D in human monocytes显示文摘 | Justine Bacchetta Jessica L Sea Rene F Chun Thomas S Lisse Katherine Wesseling‐Perry Barbara Gales John S Adams Isidro B Salusky Martin Hewison | 2012 | J Bone Miner Res2012，，1： | 1 |
| 6 | An update on vitamin D and human immunity 显示文摘 | Martin Hewison | 2012 | Clin Endoerinol (Oxf)2012，76，3： | 1 |
| 7 | Vitamin D and the intracrinology of innate immunity显示文摘 | Martin Hewison | 2010 | Molecular and Cellular Endocrinology2010，，2： | 1 |
| 8 | 11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response显示文摘 | Jeremy W. Tomlinson Elizabeth A. Walker Iwona J. Bujalska Nicole Draper Gareth G. Lavery Mark S. Cooper Martin Hewison Paul M. Stewart | 2004 | Endocrine Reviews2004，，5： | 1 |
| 9 | Validating clear air absorption models using ground-based microwave radiometers and vice-versa显示文摘 | Hewison T J Cimini D Martin L | | 0，，01： | 1 |
| 10 | Vitamin D as a Cytokine and Hematopoetic Factor显示文摘 | Martin Hewison Mercedes A. Gacad Jacques Lemire John S. Adams | 2001 | Reviews in Endocrine and Metabolic Disorders2001，，2： | 1 |
| 11 | Vitamin D and the Immune System: New Perspectives on an Old Theme显示文摘 | Martin Hewison | 2010 | Endocrinology and Metabolism Clinics of North America2010，，2： | 1 |
| 12 | Vitamin D and hematopoiesis显示文摘 | Christopher M. Bunce Geoffrey Brown Martin Hewison | 1997 | Trends in Endocrinology & Metabolism1997，，6： | 1 |
| 13 | Vitamin D and barrier function:a novel role for extra-renal 1α-hydroxylase显示文摘 | Martin Hewison Daniel Zehnder Ronjon Chakraverty | 2004 | Molecular and Cellular Endocrinology2004，215，： | 1 |
| 14 | Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling显示文摘 | Thomas S. Lisse Martin Hewison John S. Adams | 2011 | Steroids2011，，4： | 1 |
| 15 | Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain显示文摘 | Darryl W. Eyles Steven Smith Robert Kinobe Martin Hewison John J. McGrath | 2004 | Journal of Chemical Neuroanatomy2004，，1： | 1 |
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