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| 1 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 2 | Zinc oxide nano-enabled microfluidic reactor for water purification and its applicability to volatile organic compounds显示文摘This paper reports fast and efficient chemical decontamination of water within a tree-branched centimeter-scale microfluidic reactor.The microreactor integrates Zinc oxide nanowires(ZnO NWs)in situ grown acting as an efficient photocatalytic nanomaterial layer.Direct growth of ZnO NWs within the microfluidic chamber brings this photocatalytic medium at the very close vicinity of the water flow path,hence minimizing the required interaction time to produce efficient purification performance.We demonstrate a degradation efficiency of 95%in o5 s of residence time in one-pass only.According to our estimates,it becomes attainable using microfluidic reactors to produce decontamination of merely 1 l of water per day,typical of the human daily drinking water needs.To conduct our experiments,we have chosen a laboratory-scale case study as a seed for addressing the health concern of water contamination by volatile organic compounds(VOCs),which remain difficult to remove using alternative decontamination techniques,especially those involving water evaporation.The contaminated water sample contains mixture of five pollutants:Benzene;Toluene;Ethylbenzene;m–p Xylenes;and o-Xylene(BTEX)diluted in water at 10 p.p.m.concentration of each.Degradation was analytically monitored in a selective manner until it falls below 1 p.p.m.for each of the five pollutants,corresponding to the maximum contaminant level(MCL)established by the US Environmental Protection Agency(EPA).We also report on a preliminary study,investigating the nature of the chemical by-products after the photocatalytic VOCs degradation process. | Imadeddine Azzouz Yamina Ghozlane Habba Martine Capochichi-Gnambodoe Frédéric Marty Jérôme Vial Yamin Leprince-Wang Tarik Bourouina | 2018 | Microsystems & Nanoengineering2018，4，1： | 4 |
| 3 | Perfusion CT allows prediction of therapy response in non-small cell lung cancer treated with conventional and anti-angiogenic chemotherapy显示文摘 | Nunzia Tacelli Teresa Santangelo Arnaud Scherpereel Alain Duhamel Valérie Deken Ernst Klotz Alexis Cortot Jean-Jacques Lafitte Frédéric Wallyn Jacques Remy Martine Remy-Jardin | 2013 | European Radiology2013，，： | 1 |
| 4 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 5 | Double gene thera- py with granulocyte colony-stimulating factor and vascular endothelial growth factor acts synergistically to im- prove nerve regeneration and functional outcome after sci- atic nerve injury in mice显示文摘 | Pereira L opes FR Martin PK | 2013 | Neuroscience2013，230，2： | 1 |
| 6 | Identification of the Fanconi anemia complementation group I gene, FANCI显示文摘 | Josephine C. Dorsman Marieke Levitus Davy Rockx Martin A. Rooimans Anneke B. Oostra Anneke Haitjema Sietske T. Bakker J?rgen Steltenpool Dezs? Schuler Sheila Mohan Detlev Schindler Fré Arwert Gerard Pals Christopher G. Mathew Quinten Waisfisz Johan P. de | 2007 | Cellular Oncology2007，，3： | 1 |
| 7 | The excavation damaged zone in clay formations time-dependent behaviour and influence on performance assessment显示文摘 | Peter Blümling Frédéric Bernier Patrick Lebon C. Derek Martin | 2006 | Physics and Chemistry of the Earth2006，，： | 1 |
| 8 | Genome-wide differences in hepatitis C-vs alcoholism-associated hepatocellular carcinoma显示文摘AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis C,10)and 5 controls.Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis C)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis C).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis.These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C.This may open novel avenues for differential therapies in this disease. | Céline Derambure Cédric Coulouarn Frédérique Caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois Celia Duclos Odile Goria Marie Gueudin Catherine Cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier | 2008 | World Journal of Gastroenterology2008，14，11： | 1 |
| 9 | Carotid artery atherosclerosis and sleep disordered breathing in healthy elderly subjects: The Synapse cohort显示文摘 | Emilia Sforza Christian Boissier Magali Saint Martin Severine Feasson Jean Claude Barthélémy Frédéric Roche | 2012 | Sleep Medicine2012，，： | 1 |
| 10 | Effec- tive-ness of different exercises and stretching physio- therapy on pain and movement in patellofemoral pain syndrome: a randomized controlled trial显示文摘 | Moyano FR Valenza MC Martin LM | 2013 | Clin Re- habil2013，27，： | 1 |
| 11 | Effects of bisoprolol on heart rate variability in heart failure显示文摘 | Francoise Pousset Xavier Copie Philippe Lechat Patrice Jaillon Jean-Pierre Boissel Martin Hetzel Frédéric Fillette Willem Remme Louis Guize Jean-Yves Le Heuzey | 1996 | The American Journal of Cardiology1996，，8： | 1 |
| 12 | Relationships among interleukin-6,tumor necrosis factor-α,adipokines,vitamin D,and chronic periodontitis显示文摘 | Teles FR Teles RP Martin L | 2012 | J Periodontol2012，83，9： | 1 |
| 13 | AFM and EBSD Combined Studies of Plastic Deformation in a Duplex Stainless Steel显示文摘 | Fr' echard S Martin F Clement C | 2006 | Materials Science and Engineering A2006，418，： | 1 |
| 14 | Influence of ABCB1 polymorphisms and docetaxel pharmacokinetics on pathological response to neoadjuvant chemotherapy in breast cancer patients显示文摘 | Pierre Lévy Joseph Gligorov Martine Antoine Keyvan Rezai Eric Lévy Frédéric Selle Pierre Saintigny Fran?ois Lokiec Danielle Avenin Karine Beerblock Jean-Pierre Lotz Jean-Fran?ois Bernaudin Anne Fajac | 2013 | Breast Cancer Research and Treatment2013，，： | 1 |
| 15 | The role of plain films and computed tomography in the evaluation of scapular neck fractures显示文摘 | McAdams TR Blevins Fr Martin TP | 2002 | Orthop Trauma2002，16，1： | 1 |
| 16 | Automated image analysis of gliomas an objective and reproducible method for tumor grading显示文摘 | H. Martin K. Voss P. Hufnagl K. Fr?lich | 1984 | Acta Neuropathologica1984，，2： | 1 |
| 17 | HySAT: An efficient proof engine for bounded model checking of hybrid systems显示文摘 | Martin Fr?nzle Christian Herde | 2007 | Formal Methods in System Design2007，，3： | 1 |
| 18 | Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence显示文摘AIM:To search for transcription dysregulation that could(1) differentiate hepatocellular carcinoma(HCC)-free from HCC-related cirrhosis(2) differentiate HCC-free cirrhosis related to HCV from that related to alcohol intake.METHODS:Using microarray analysis,we compared transcript levels in HCC-free cirrhosis(alcoholism:7;hepatitis C:7),HCC-associated cirrhosis(alcoholism:10;hepatitis C:10) and eight control livers.The identified transcripts were validated by qRT-PCR in an independent cohort of 45 samples(20 HCC-free cirrhosis;15 HCC-associated cirrhosis and 10 control livers).We also confirmed our results by immunohistochemistry.transcripts which differentiated between alcoholic-related cirrhosis,HCV-related cirrhosis and control livers.They mainly corresponded to down-regulation.Dysregulation of Signal Transduction and Activator of Transcription-3(STAT-3) was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free cirrhosis.In contrast,in HCC,such transcription dysregulations were not observed.CONCLUSION:We report that transcriptional dysregulations exist in HCC-free cirrhosis,are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition. | Frédérique Caillot Céline Derambure Paulette Bioulac-Sage Arnaud Franois Michel Scotte Odile Goria Martine Hiron Maryvonne Daveau Jean-Philippe Salier | 2009 | World Journal of Gastroenterology2009，15，3： | 1 |
| 19 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 20 | Intraocular hemorrhage in sudden increased intracranial pressure ( Terson syndrome) 显示文摘 | Diaz AG Carmena JJ Martin FR Lopez PD Casado MJM | 1979 | Ophthalmology1979，179，3： | 1 |
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