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| 1 | Levomilnacipran and vortioxetine:Review of new pharmacotherapies for major depressive disorder显示文摘Major depressive disorder(MDD) is a common psychiatric disorder with an estimated lifetime prevalence rate in the range of 13% to 16% in the United States population. Patients with MDD often have symptoms such as depressed mood, loss of interest or pleasure in usual activities, changes in eating or sleeping patterns, fatigue, difficulty concentrating and thoughts of suicide. Although many pharmacotherapy treatment options are available for MDD, antidepressants can oftencause adverse effects that could affect adherence to the medication. Additionally, it is estimated that MDD is unremitting in 15% of patients and 35% can have recurrent episodes. Given the high rate of recurrence and the adverse effects associated with existing medications, new treatment options for depression are needed. Both levomilnacipran and vortioxetine are new antidepressants that were approved by the food and drug administration in 2013 for the treatment of MDD in adults. Levomilnacipran is a serotonin norepinephrine reuptake inhibitor that was effective in several short term studies and sustained efficacy and tolerability was demonstrated in a 48-wk extension study. Vortioxetine is a multi-modal antidepressant and it is thought to work via inhibition of the serotonin(5-HT) transporter, 5-HT3 A, 5-HT7 and 5-HT1 D antagonist, a 5-HT1 B partial agonist, and a 5-HT1 A agonist. Vortioxetine was effective in the treatment of MDD in both short-term trials as well as in the prevention of relapse in a 24-36 wk trial. Sustained efficacy and tolerability was demonstrated in several long-term open-label trials. Further studies comparing levomilnacipran and vortioxetine to other currently available antidepressants are needed to establish its place in therapy. | Mei T Liu Megan E Maroney Evelyn R Hermes-DeSantis | 2015 | World Journal of Pharmacology2015，4，1： | 3 |
| 2 | An in vitro biomechanicel evaluation of bone cements used in percutaneous vertebroplasty显示文摘 | Maroney M Fenten DC | 1999 | Bone1999，25，2： | 1 |
| 3 | Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a no- vel inhibitor of the JNK signaling pathway显示文摘 | Anna C Maroney Marcie A Clicksman | 1998 | The Journal of Neuroscience1998，18，1： | 1 |
| 4 | An in vitro biome chanical evaluation of bone cements percutanous vertebroplasty显示文摘 | Belkoff SM Maroney M Fenton DC | 1999 | Bone1999，25，2： | 1 |
| 5 | Motoneuron apoptosis is blocked by CEP-134 7 ( KT 7515 ), a novel inhibitor of the JNK signaling pathway 显示文摘 | Maroney A C Glicksman M A Basma A N | 1998 | J Neurosci1998，18，1： | 1 |
| 6 | A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation 显示文摘 | Maroney PA Chamnongpol S Souret F | 2007 | RNA2007，13，6： | 1 |
| 7 | Spectroscopic and computational studies of Ni superoxide dismutase: Electronic structure contributions to enzymatic function 显示文摘 | Ficdler AT Bryngelson PA Maroney M J | 2005 | Journal oi the American Chemical Society2005，127，15： | 1 |
| 8 | Multiple cis-aeting elements are required for RNA polymerase III transcription of the gene encoding H1 RNA, the RNA component of human RNase显示文摘 | Hannon G J Chubb A Maroney P A | 1991 | Biol Chem1991，266，22： | 1 |
| 9 | Structure/function relationships in nickel metallobiochernistry显示文摘 | Maroney MJ | 1999 | Current Opinion in Chemical Biology1999，3，2： | 1 |
| 10 | An in vitro biomechanical evaluation of bone cements used in percutaneous vertebroplasty显示文摘 | Belkoff SM Maroney M Fenton DC | 1999 | Bone1999，25，2： | 1 |
| 11 | Active tissue factor pathway inhibitor is expressed on the surface of coated platelets显示文摘 | Maroney SA Haberichter SL Friese P | 2007 | Blood2007，109，5： | 1 |
| 12 | An in vitro biomechanical evaluation of bone cements used in percuta- neous vertebroplasty显示文摘 | Belkoff SM Maroney M Fenton DC | 1999 | Bone1999，25，2： | 1 |
| 13 | Hepatocellular carcinoma: strategy for optimizing surgical resection, transplantation and palliation 显示文摘 | Fisher RA Maroney TP Fulcher AS | 2002 | Clin Transplant2002，16，7： | 1 |
| 14 | My Entire Waking Life 显示文摘 | Maroney Kevin | 2001 | The Games Journal2001，，5： | 1 |
| 15 | Intrathoracic fracture - dislocation of the proximal humerus treated with reverse total shoulder arthroplasty 显示文摘 | Maroney SS Devinney DS | 2009 | Orthopedics2009，12，： | 1 |
| 16 | An in vitro biomechanical evaluation of bone cements used in percutaneous vertebroplasty显示文摘 | Belkoff SM Maroney M Fenton DC | | 0，，2： | 1 |
| 17 | Intrathoracic fracture-dislocation of the proximal humerus treated with reverse total shoulder arthro- plasty显示文摘 | Maroney SS Devinney DS | 2009 | Orthopedics2009，32，12： | 1 |
| 18 | Beyond the Pricing Issue: A Normative Survey of Periodicals Management 显示文摘 | Hughes G Maroney D Shelton J M | 1992 | The Serials Librarian1992，21，4： | 1 |
| 19 | Multiple cis-acting elements are required for RNA polymerase Ⅲ transcription of the gene encoding H1 RNA, the RNA component of human RNase P显示文摘 | Hanmon G Chubb A Maroney PA | 1991 | J Biol Chem1991，266，22： | 1 |
| 20 | A rapid,quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation显示文摘 | Maroney P A Chamnongpol S Souret F | 2007 | RNA2007，13，6： | 1 |
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