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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Production of 5-amino-8-hydroxyquinoline and some of its derivatives显示文摘 | Markov K Markova N Mitev S | 1977 | Sofia1977，22，1： | 2 |
| 3 | Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: Protective effect of selenium显示文摘 | OGNJANOVIC B I MARKOVIC S D PAVLOVIC S Z | 2008 | Physiol Res2008，57，3： | 1 |
| 4 | Decrease of aflatoxin B1 in yogurt and acidified milk显示文摘 | RASIC J L SKRINJAR M MARKOV S | 1991 | Mycopathologia1991，113，： | 1 |
| 5 | Text-Independent Speaker Recognition System Using Frame Level Likelihood Processing 显示文摘 | Markov K Nakagawa S | 1996 | Technical Report of IEICE1996，96，17： | 1 |
| 6 | Squamous metaplasia amplifies pathologic epit helial-mesenchymal interactions in COPD patients显示文摘 | Araya J Cambier S Markovics JA | | 0，，： | 1 |
| 7 | Signature-based SER analysis and design of logic circuits 显示文摘 | KRISHNASWAMY S PLAZA S M MARKOV I L | 2009 | IEEE Trans Comput-Aided Des Integr Circ ~ Syst2009，28，1： | 1 |
| 8 | Physical and thermal eharacterisation of chiral ome-prazole sodium salts显示文摘 | Agotonovic-Kustrin S Glass B | 2006 | J Pharm Biomed Anal2006，42，1： | 1 |
| 9 | Influence of Alkali Metal Cations upon the Kolbe-Schmitt Reaction Mechanism显示文摘 | Markovic Z Markovid S Begovid N | 2006 | Chem Inf Model2006，46，5： | 1 |
| 10 | Partial mutual information based input variable selec- tion for supervised learning approaches to voice activi- ty detection显示文摘 | MARKOVIC I JURIC-KAVELJ S PETROVIC I | 2013 | Applied Soft Computing2013，13，11： | 1 |
| 11 | What need to be known about the therapy with static magnetic fields显示文摘 | Marko S Markov | 2009 | Environmentalist2009，29，2： | 1 |
| 12 | Gliomas induce and exploit mieroglial MT1-MMP expression for tumor expansion 显示文摘 | Markovic DS Vinnakota K Chirasani S | 2009 | Proe Natl Acad Sci U S A2009，106，12： | 1 |
| 13 | Oxidation of solid alu- minium silicon alloys in air显示文摘 | Yaneva S Stojanova L Markov T | 1987 | Crystal Research and Tech- nology1987，22，2： | 1 |
| 14 | Spike sorting : the first step indecoding the brain 显示文摘 | Gibson S Judy JW Markovic D | 2012 | IEEE Signal Proc Mag2012，129，1： | 1 |
| 15 | Prospective randomised trial evaluating a paclitaxel-coated balloon in patients treated with endo- thelial progenitor cell capturing stents for de novo coronary artery dis- ease 显示文摘 | Wobrle J Birkemeyer R Markovic S | 2011 | Heart2011，97，16： | 1 |
| 16 | An activin re- ceptor IIA ligand trap promotes erythropoiesis result- ing in a rapid induction of red blood cells and haemo- globin显示文摘 | Carrancio S Markovics J Wong P | 2014 | Br J Haematol2014，165，6： | 1 |
| 17 | Pectin methylesterases:sequence-structural features and phylogenetic relationships显示文摘 | Markovic^ O Janec^ek S | 2004 | Carbohydrate Research2004，339，13： | 1 |
| 18 | Sealing of Muscle Power to Body Size: the Effect of Stretch - Shortening Cycle 显示文摘 | Markovic G Jaric S | 2005 | European Journal of Ap- plied Physiology2005，95，1： | 1 |
| 19 | Adv Biochem Eng显示文摘 | Markov S A Bazin M Hall D O | 1995 | Biotechnol1995，52，： | 1 |
| 20 | Nuclear medicine diagnosis of pheochromocytoma with metaiodobenzyiguanidine显示文摘 | Pucar D Markovic S | 2002 | Srp Arh Celok Lek2002，2，： | 1 |
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