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| 1 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 2 | Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions显示文摘Point-of-care(POC) tests enable rapid results and are well established in medical practice.Recent advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic pathways.This review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was performed.Papers reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were included.Studies recovered were heterogeneous and therefore results are presented as a narrative review.Six diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical application.POC devices have a proven role in the diagnosis of gastrointestinal cancer.Barriers to their implementation exist and the transition from experimental to clinical medicine is currently slow.New technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival. | Jeremy R Huddy Melody Z Ni Sheraz R Markar George B Hanna | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 3 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 4 | Systematic review and pooled analysis assessing the association between elder- ly age and outcome following siJrgcl resection of esophageal ma- lignancy显示文摘 | Markars R Karthikesalirtgam A Thrumurhy S | 2012 | Dis EsoPhagus2012，26，3： | 1 |
| 5 | Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children 显示文摘 | Markar SR Blackburn S Cobb R | 2012 | J Gastrointest Surg2012，16，10： | 1 |
| 6 | Laparoscopic versus open colorectal resection in the elderly population显示文摘 | Grailey K Markar S R Karthikesalingam A | 2013 | Surg Endosc2013，27，1： | 1 |
| 7 | Laparoscopic versus open appendectomy for complicated and un- complicated appendicitis in children显示文摘 | Markar S R Blackburn S Cobb R | 2012 | J Gastrointes- tinal Surg2012，16，： | 1 |
| 8 | Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children显示文摘 | Markar SR Blackburn S Cobb R | 2012 | J Gastrointest Surg2012，16，10： | 1 |
| 9 | A meta -analysis of minimally invasive versus traditional open vein harvest technique for coronary artery bypass graft surgery显示文摘 | Markar SR Kutty R Edmonds L | 2010 | Interact CardioVasc Thorac Surg2010，10，2： | 1 |
| 10 | Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children显示文摘 | MARKAR SR BLACKBURN S COBB R | 2012 | J Gastrointest Surg2012，16，10： | 1 |
| 11 | A meta-analysis of minimally invasive versus traditional open vein harvest technique for coronary artery bypass graft surgery 显示文摘 | Markar SR Kutty R Edmonds L | 2010 | Interact Cardio Vasc Thorac Surg2010，10，2： | 1 |
| 12 | A Meta-analysis of minimally invasive versus traditional open vein harvest technique for coronary artery bypass graft surgery显示文摘 | Markar SR Kutty R Edmonds L | 2010 | Interact Cardiovasc Thorac Surg2010，10，2： | 1 |
| 13 | Laparoscopic ver- sus open appendicectomy in obese patients显示文摘 | Markar S R Venkat Raman V Ho A | 2011 | Int J Surg2011，9，6： | 1 |
| 14 | Single-incision laparoscopic surgery(SILS)vs conventional multiport cholecystectomy:systematic review and meta-analysis显示文摘 | Markar S R Karthikesalingam A Thrumurthy S | 2012 | Surg Endosc2012，26，5： | 1 |
| 15 | The role of integrated F- 18-FDG-PET scanning in the detection of M1 disease in oesophageal adenocarcinoma and impact on clinical management显示文摘 | Vyas S Markar S R Iordanidou L | 2011 | J Gastrointest Surg2011，15，12： | 1 |
| 16 | A meta-analysis of minimally invasive versus traditional open vein harvest technique for coronary artery bypass graft surgery显示文摘 | Markar SR Kutty R Edmonds L | 2010 | Interact Cardiovasc Thorac Surg2010，10，2： | 1 |
| 17 | Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children 显示文摘 | Markar SR Blackburn S Cobb R | 2012 | J Gastrointest Surg2012，16，10： | 1 |
| 18 | A meta-analysis of minimally in- vasive versus traditional open vein harvest technique for coronary artery bypass graft surgery 显示文摘 | Markar SR Kutty R Edmonds L | 2010 | Interact Cardiovasc Thorac Surg2010，10，2： | 1 |
| 19 | Synovial sarcoma of the temporomandibular joint显示文摘 | White R D Markar J Steckler R M | 1992 | J Oral Maxillofac Surg1992，50，11： | 1 |
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