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| 1 | Management of necrotizing pancreatitis显示文摘Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding. | John Slavin Paula Ghaneh Robert Sutton Mark Hartley Peter Rowlands Conall Garvey Mark Hughes John Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 21 |
| 2 | Adjuvant therapy in pancreatic cancer显示文摘The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic csncer, leading to a drsmatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone.The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients. | Paula Ghaneh John Slavin Robert Sutton Mark Hartley John P Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 3 |
| 3 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | The Lancet . 2009 (9702)2009，，： | 2 |
| 4 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | 2009 (9702)2009，，9702： | 2 |
| 5 | Innovations in governance显示文摘 | Mark Moore Jean Hartley | 2008 | Public Management Review2008，，1： | 1 |
| 6 | Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE ?/? Mice Measured by Doppler Ultrasound显示文摘 | Craig J. Hartley Anilkumar K. Reddy Sridhar Madala Lloyd H. Michael Mark L. Entman George E. Taffet | 2007 | Ultrasound in Medicine & Biology2007，，4： | 1 |
| 7 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | The Lancet2009，，9702： | 1 |
| 8 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | The Lancet2009，，9702： | 1 |
| 9 | Interdependence and Cooperation in Industrial Buyer- Supplier Relationships 显示文摘 | TURNER GREGORY B LEMAY STEPHEN A HARTLEY MARK | 2000 | Journal of Marketing Theory and Practice2000，，8： | 1 |
| 10 | Interdependence and Cooperation in Industrial Buyer Supplier Relationships显示文摘 | Turner Gregory B Lemay Stephen A Hartley Mark | 2000 | Journal of Marketing Theory and Practice2000，，8： | 1 |
| 11 | 家具的色彩设计显示文摘桃红、柳绿、云白、天蓝,似乎一来到这个世界,我们就长久地生活在颜色的环绕之中。时尚消费、设计开发,甚至性格分析,随意走进一种领域,我们都不难发现,色彩的应用和渗透早已无孔不入。对于家具,一位意大利设计师在受访时,亦曾如此谈及:在同质化产品日渐增多的当今,色彩已成为产品脱颖而出的关键要素之一。一件色彩搭配得宜的产品,不仅具有更高的吸引力,还可以帮助识别公司,确立良好的品牌形象。那么,事实是否的确如此?心理学家的研究证实了这一观点:色彩对视觉的影响最大。看到不同的颜色,人的精神状态和心理情绪也会相应地受到不同的影响。即便地域、国度、民族、性格不尽相同,都一样通用此理。比如,在所有人的眼中,红黄都是暖色的代表,蓝紫是冷色的代言,黑白则作为中性色,被称为永恒的经典。正因为深深浅浅的色彩,带来明明暗暗的感受,人们在春夏秋冬、四季轮回的更替之间,运用色彩的功能,不厌其烦地耍玩着搭配的游戏,为生活增添了无穷的乐趣。 | 56studio Mark vander Gronden Seletti Ctrlzak Art & Design Contempo Anthony Hartley Merel Karhot Anton Alvarez Wonmin Park tombend kovski Javier Moreno Beneyto Daisuke Motogi 陈志芳 | 2013 | 现代装饰(家居)2013，0，10： | 0 |
| 12 | Characteristics of viral specimens collected from asymptomatic and fatal cases of COVID-19显示文摘We sought to determine the characteristics of viral specimens associated with fatal cases,asymptomatic cases and non-fatal symptomatic cases of COVID-19.This included the analysis of 1264 specimens found reactive for at least two SARS-CoV-2 specific loci from people screened for infection in Northern Nevada in March-May of 2020.Of these,30 were specimens from fatal cases,while 23 were from positive,asymptomatic cases.We assessed the relative amounts of SARS-CoV-2 RNA from sample swabs by real-time PCR and use of the threshold crossing value(Ct).Moreover,we compared the amount of human RNase P found on the same swabs.A considerably higher viral load was found to be associated with swabs from cases involving fatality and the difference was found to be strongly statistically significant.Noting this difference,we sought to assess whether any genetic correlation could be found in association with virus from fatal cases using whole genome sequencing.While no common genetic elements were discerned,one branch of epidemiologically linked fatal cases did have two point mutations,which no other of 156 sequenced cases from northern Nevada had.The mutations caused amino acid changes in the 3′-5′exonuclease protein,and the product of the gene,orf8. | Andrew J.Gorzalski Paul Hartley Chris Laverdure Heather Kerwin Richard Tillett Subhash Verma Cyprian Rossetto Sergey Morzunov Stephanie Van Hooser Mark W.Pandori | 2020 | The Journal of Biomedical Research2020，34，6： | 0 |
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