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| 1 | Diet and epigenetics in colon cancer显示文摘Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer. | Minna Nystrm Marja Mutanen | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 3 | Utilisation of a multitubular reactor system for parallel screening of catalysts for ring opening of decalin in continuous mode显示文摘 | Kalle Arve P?ivi M?ki-Arvela Kari Er?nen Marja Tiitta Tapio Salmi Dmitry Yu. Murzin | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 4 | Changes in plasma lyaozyme and blood leucocyte leveal lf hatechery-reared Atlantic Salmon and sea trout(Salmo trutta L) during parr-smolt tramsformation显示文摘 | Marja M Antti S | 1992 | Aquaculture1992，106，： | 1 |
| 5 | Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry显示文摘 | Martin H?glund Fredrik Sandin Karin Hellstr?m Mats Bj?reman Magnus Bj?rkholm Mats Brune Arta Dreimane Marja Ekblom S?ren Lehmann Per Ljungman Claes Malm Berit Markev?rn Kristina Myhr-Eriksson Lotta Ohm Ulla Olsson-Str?mberg Anders Sj?lander Hans Wadenvik | 2013 | Blood2013，，： | 1 |
| 6 | Development of an animal model of selective coronary atherosclerosis显示文摘 | Dimitre M Marja JA Gerhard R | 2000 | Coronary Artery Dis2000，11，： | 1 |
| 7 | Medication use among inflammatory bowel disease patients: excessive consumption of antidepressants and analgesics显示文摘 | Johanna Haapamä ki Antti Tanskanen Risto P. Roine Marja Blom Ulla Turunen Juhani Mä ntylä Martti A. Fä rkkilä Perttu E.T. Arkkila | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 1 |
| 8 | Changes in plasma lyso-zyme and blood leucocyte levels of hatchery-reared Atlantic Salmon and sea trout during parr-smolt transformation显示文摘 | Marja M Antti S | 1992 | Aquaculture1992，106，： | 1 |
| 9 | Swollenin,a Trichoderma reesei protein with sequence similarity to the plant expansins, exhibits disruption activity on cellulosic materials显示文摘 | Saloheimo M Paloheimo Marja Hakola S | 2002 | Eur J Biochem2002，269，17： | 1 |
| 10 | Impor- tance of soil calcium for composition of understory vegetation in boreal forests of Finnish Lapland 显示文摘 | Paavo N Maarit M Nils G Eija H Marja L S Raimo S | 2011 | Biogeochemistry2011，102，： | 1 |
| 11 | Autoantibodies against oxidized low-density lipaprotein predicting my cardial infarction 显示文摘 | Marja P Matti M Vesa M | 1994 | Arch Intern Med1994，154，： | 1 |
| 12 | Changes in plasma lysozyme and blood leucocyte levels of hatcheryreared Atlantic salmon and sea trout (Salmo tuotta L)during parr-smolt transformation显示文摘 | Marja M Antti S | 1992 | Aquaculture1992，106，： | 1 |
| 13 | Changes in plasma lysozyme and blood leucocyte levels of hatchery-reared Atlantic Salmon and sea trout during parr-smolt transformation显示文摘 | MARJA M ANTTI S | 1992 | Aquaculture1992，106，： | 1 |
| 14 | Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate With Clinical Presentation of Patients With Celiac Disease显示文摘 | Juha Taavela Kalle Kurppa Pekka Collin Marja–Leena L?hdeaho Teea Salmi P?ivi Saavalainen Katri Haimila Heini Huhtala Kaija Laurila Harri Siev?nen Markku M?ki Katri Kaukinen | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | Usefulness of monitoring β-glucuronidase in pleural effusions显示文摘 | Nicolle A M Marjolein D R Marja P V | 1999 | Clin Biochem1999，32，： | 1 |
| 16 | Plasma alkylresorcinols and urinary alkylresorcinol metabolites as biomarkers of cereal fiber intake in Finnish women显示文摘 | AUBERTIN-LEHEUDRE M KOSKELA A MARJA MAA A | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，9： | 1 |
| 17 | Changes in plasma lysozyme and blood leucocyte levels of hatchery-reared Atlantic Salmon and sea trout (Salmo trutta L) during parr-smolt transformation显示文摘 | MARJA M ANTTI S | 1992 | Aquaculture1992，106，： | 1 |
| 18 | Changes in plasma lysozyme and blood leucocyte levels of hatcheryreared atlantic salmon and sea trout ( salmo tuotta L) during parr-smolt transformation 显示文摘 | Marja M Antti S | 1992 | Aquaculture( S0044-8486 )1992，106，： | 1 |
| 19 | Thymidylate synthase expression:An independent prognostic factor for local recurrence,distant metastasis,disease-free and overall survival in rectal cancer显示文摘 | David Edler Marja Hallstrm Patrick G Johnston | 2000 | Clin Cancer Res2000，6，： | 1 |
| 20 | Effect of anaesthesia on contrast-enhanced ultrasound of the feline spleen显示文摘 | Merja R L Marja R R Outi M V | | 0，，： | 1 |
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