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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021,18,1: | 3 |
| 2 | Carbon -supported tungsten and nickel catalysts for hydrodesul-furization and hydrogenation reactions 显示文摘 | Pawelec B Mariscal R Fierrp J L G | 2001 | AppliedCatalysis A2001,206,2: | 1 |
| 3 | Biodiesel preparation using Li/CaO catalysts:Activation contribution 显示文摘 | ALONSO D M MARISCAL R GRANADOS M L | 2009 | Catalysis Today2009,143,12: | 1 |
| 4 | Biodiesel from sunflower oil by using activated cakium oxide显示文摘 | LOPEZ GRANADOS M ZAFRA POVES M D MARTIN ALONSO D MARISCAL R CABELLO GALISTEO F MORENO-TOST R SANTAMARIA J FIERRO J L G | | 0,,: | 1 |
| 5 | Modem management of locally advanced cervical carcinoma显示文摘 | Duefias - Gonzalez A Cetina L Mariscal I | 2003 | Cancer Treat Rev2003,29,5: | 1 |
| 6 | Carbon-supported Tungsten and Nickel Catalysts for Hydrodesulfurization and Hydrogenation Reactions显示文摘 | Pawelec B Mariscal R Fierro J L G | 2001 | Applied Catalysis A: General2001,206,: | 1 |
| 7 | Modern management of locally advanced cervical carcinoma 显示文摘 | Duenas-Gonzalez A Cetina L Mariscal I | 2003 | Cancer Treat Rev2003,29,2: | 1 |
| 8 | 查看详情显示文摘 | Pawelec B Mariscal R Navarro R M van Bokhorst S Rojas S Fierro J L G | | 0,,: | 1 |
| 9 | Modem management of locally advanced cervical carcinoma 显示文摘 | Duenas - Gonzalez A Cetina L Mariscal I | 2003 | Cancer Treat Rev2003,29,5: | 1 |
| 10 | The effect of calcination temperature on the oxygen storage and release properties of CeO2 and Ce-Zr-O metal oxides modified by phosphorus incorporation显示文摘 | LARESE C GRANADOS M L MARISCAL R | 2005 | Applied Catalysis B:Environmental2005,59,12: | 1 |
| 11 | Modern management of locally advanced cervical carcinoma 显示文摘 | Duenas-Gonzalez A Cetina L Mariscal I | 2003 | Cancer Treat Rev2003,29,2: | 1 |
| 12 | Carbon-supported tungsten and nickel catalysts for hydrodesulfurization and hydrogenation reactions显示文摘 | Pawelec B Mariscal R Fierro J L G | 2001 | Applied Catalysis A: General2001,206,2: | 1 |
| 13 | Carbon-supported tungsten and nickel catalysts for hydrodesulfurization and hydrogenation reactions显示文摘 | Pawelec B Mariscal R Fierro J L G | 2001 | Applied Catalysis A:General2001,206,2: | 1 |
| 14 | MAGUK proteins : structure and role in the tight junction显示文摘 | Gonzalez- Mariscal L Betanzos A Avila- Flores A | 2000 | Semin Cell Dev Biol2000,11,: | 1 |
| 15 | Carbon-supportedtungsten and nickel catalysts for hydrodesulfurization andhydrogenation reactions显示文摘 | Pawelec B Mariscal R Fierro J L G | 2001 | Applied Catalysis A : General2001,206,2: | 1 |
| 16 | Changes in the distribution of ZO - 1, occludin, and claudins in the rat uterine epithelium during the estrous cycle显示文摘 | Mendoza - Rodriguez CA Gonzalez - Mariscal L Cerbon M | 2005 | Cell Tissue Res2005,319,2: | 1 |
| 17 | Reactivation of a commemial diesel oxidation catalyst by acid washing显示文摘 | Galisteo F C Mariscal R Granados M L Fierro J L Brettes P Salas O | | 0,,10: | 1 |
| 18 | Tight Junctionproteins显示文摘 | Gonzalez - Mariscal L Betanzos A Nava P | 2003 | Prog Biophys Mol Biol2003,81,1: | 1 |
| 19 | Modern management of locally advanced cervical carcinoma 显示文摘 | Duenas-Gonzalez A Cetina L Mariscal L | 2003 | Cancer Treat Rev2003,29,: | 1 |
| 20 | Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy显示文摘 | Segura-Pacheco B Trejo-Becerril C Perez-Cardenas E Taja-Chayeb L Mariscal I Chavez A | 2003 | Clin Cancer Res2003,9,: | 1 |