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| 1 | Type 2 diabetes mellitus and Alzheimer's disease显示文摘Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the areas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after controlling for diabetic vascular disease and inadequate cerebral circulation. Most recent studies have focused on the role of insulin and insulin resistance as possible links between diabetes and AD. Disturbances in brain insulin signaling mechanisms may contribute to the molecular, biochemical, and histopathological lesions in AD. Hyperglycemia itself is a risk factor for cognitive dysfunction and dementia. Hypoglycemia may also have deleterious effects on cognitive function. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause sub-clinical brain damage, and permanent cognitive impairment. Futuretrials are required to clarify the mechanistic link, to address the question whether cognitive decline may be prevented by an adequate metabolic control, and to elucidate the role of drugs that may cause hypoglycemic episodes. | Mario Barbagallo Ligia J Dominguez | 2014 | World Journal of Diabetes2014，5，6： | 22 |
| 2 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 3 | Magnesium and type 2 diabetes显示文摘Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium(Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulinand glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profiles in diabetic patients have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. The aim of this review is to revise current evidence on the mechanisms of Mg deficiency in diabetes and on the possible role of Mg supplementation in the prevention and management of the disease. | Mario Barbagallo Ligia J Dominguez | 2015 | World Journal of Diabetes2015，6，10： | 4 |
| 4 | 领导者–跟随者Thomson跳环系统的自抗扰控制设计(英文)显示文摘将用电磁方法悬浮起来的一对环构成领导者–跟随者系统实现对光滑参考轨线的跟踪要求.这一任务通过设计具有对扰动进行在线估计与补偿功能的自抗扰控制器(ADRC)实现.本文设计方法与传统ADRC的主要不同在于领导者和跟随者的跟踪控制器设计都是基于平坦输出的线性化近似系统.超出线性化近似有效区域的大的高度偏差所导致的未知非线性则被视为扰动,这个扰动借助于线性扩张观测器进行在线估计并通过线性反馈控制器进行消除.实验结果检验了本文所提方法的有效性. | Mario RAMIREZ-NERIA José L GARCIA-ANTONIO Hebertt J SIRA-RAMIREZ Martin VELASCO-VILLA Rafael CASTRO-LINARES | 2013 | 控制理论与应用2013，30，12： | 3 |
| 5 | 剖宫产术后妇女嚼口香糖有助于肠蠕动恢复并缩短住院时间显示文摘背景 剖宫产术是世界范围内普遍使用的一种外科手术方式。术后肠梗阻(POI)是腹部手术后的常见并发症,定义为:外科手术后协调性肠蠕动短暂停止,从而阻止肠内容物和/或摄入物的有效输送。POI延缓术后恢复,延长住院时间,并使医疗费用增加。尽管有证据表明胃肠(GI)术后嚼El香糖有助于减少肠梗阻,但一项相冲突的循证证据限制了其在剖宫产术后的使用。 | Mario Lepore J Edward Fitzgerald 陈华云 | 2015 | 英国医学杂志中文版2015，0，9： | 2 |
| 6 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 7 | Identification of Gene Expression–Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes显示文摘 | Andrea Pellagatti Axel Benner Ken I. Mills Mario Cazzola Aristoteles Giagounidis Janet Perry Luca Malcovati Matteo G. Della Porta Martin J?dersten Amit Verma Emma-Jane McDonald Sally Killick Eva Hellstr?m-Lindberg Lars Bullinger James S. Wainscoat Jacquel | 2013 | Journal of Clinical Oncology2013，，28： | 2 |
| 8 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 9 | Early Esophageal Cancer: Pattern of Lymphatic Spread and Prognostic Factors for Long-Term Survival After Surgical Resection显示文摘 | Hubert J. Stein Marcus Feith Bjorn L. D. M. Bruecher Jorg Naehrig Mario Sarbia J Rudiger Siewert | 2005 | Annals of Surgery2005，，4： | 2 |
| 10 | Role of the vagus nerve on the development of postoperative ileus显示文摘 | Zhirong Gao Mario H. Müller Martina Karpitschka Sarah Mittler Michael S. Kasparek Bernhard Renz Andrej Sibaev J?rg Glatzle Yongyu Li Martin E. Kreis | 2010 | Langenbeck’s Archives of Surgery2010，，4： | 1 |
| 11 | SiC versus Si-Evaluation of potentials for performance improvement of inverter and dc-dc converter systems by SiC power semiconductors显示文摘 | Biela J Mario S Waffier S | 2011 | IEEE Transactions on Industrial Electronics2011，58，7： | 1 |
| 12 | Semiconductor nanocrystals as fluorescent biological labels显示文摘 | MARCEL B J MARIO M PETER G | 1998 | Science1998，281，： | 1 |
| 13 | Tempo-rary scaffolding of coronary arteries with bioab-sorbable magnesium stents:aprospective,non-ran-domised multicent retrial显示文摘 | Erbel R Mario CD Bartunek J | | 0，，： | 1 |
| 14 | Double recurrent interaction V1-V2-V4 based neural architecture for color natural scene boundary detection and surface perception显示文摘 | Díaz-Pernas F J Mario M Z Míriam A R | 2014 | Applied Soft Computing2014，21，： | 1 |
| 15 | A method for calibration and validation subset partitioning显示文摘 | ROBERTO K H G MARIO C U A GLEDSON E J | 2005 | Talanta2005，67，4： | 1 |
| 16 | Effects of probiotics therapy on the activity and activation of rheumatoid arthritis-a pilot study显示文摘 | Hatakka K Mario J Korpela M | | 0，，： | 1 |
| 17 | Array-based identificationof species of the genera Abiotrophia, Enterococcus,Granulicatella, and Streptococcus 显示文摘 | Sheng K T Lee J T Mario V | 2006 | Journal of ClinicalMicrobiology2006，44，12： | 1 |
| 18 | Using Pivots to Speed - Up K- Medoids Clustering显示文摘 | A P Adriano A N Mario T J Caetano | 2011 | Journal of Information and Data Man- agement2011，2，2： | 1 |
| 19 | Oriented immobilization of enzymes made fit for applied biocatalysis: non- covalent attachment to anionic supports using Zbas2 module显示文摘 | WIESBAUER J B JUAN M M MARIO M | 2011 | Chem Cat Chem2011，3，8： | 1 |
| 20 | Comparison of fluconazole with oral polyenes in the prevention of fungal infections in neutropenic patients显示文摘 | Thomas Egger Alois Gratwohl André Tichelli Mario Uhr Christine Stebler Gysi Jakob Passweg Miklos Pless Martin Wernli Ulrich Buser Jürg Wuhrmann R.N. Reno Frei Catherine Nissen Bruno Speck | 1995 | Supportive Care in Cancer1995，，2： | 1 |
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