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| 1 | Tidally induced upwelling off Yangtze River estuary and in Zhejiang coastal waters in summer显示文摘MASNUM wave-tide-circulation coupled numerical model (MASNUM coupled model, hereinafter) is de-veloped based on the Princeton Ocean Model (POM). Both POM and MASNUM coupled model are ap-plied in the numerical simulation of the upwelling off Yangtze River estuary and in Zhejiang coastal waters in summer. The upwelling mechanisms are analyzed from the viewpoint of tide, and a new mechanism is proposed. The study suggests that the tidally inducing mechanism of the upwelling in-cludes two dynamic aspects: the barotropic and the baroclinic process. On the one hand, the residual currents induced by barotropic tides converge near the seabed, and upwelling is generated to maintain mass conservation. The climbing of the residual currents along the sea bottom slope also contributes to the upwelling. On the other hand, tidal mixing plays a very important role in inducing the upwelling in the baroclinic sea circumstances. Strong tidal mixing leads to conspicuous front in the coastal waters. The considerable horizontal density gradient across the front elicits a secondary circulation clinging to the tidal front, and the upwelling branch appears near the frontal zone. Numerical experiments are de-signed to determine the importance of tide in inducing the upwelling. The results indicate that tide is a key and dominant inducement of the upwelling. Experiments also show that coupling calculation of the four main tidal constituents (M2, S2, K1, and O1), rather than dealing with the single M2 constituent, im-proves the modeling precision of the barotropic tide-induced upwelling. | L XinGang1,2,3,4, QIAO FangLi1,2, XIA ChangShui1,2 & YUAN YeLi1,2 1 The First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China 2 Key Laboratory of Marine Science and Numerical Modeling (MASNUM), State Oceanic Administration, Qingdao 266061, China 3 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 4 Graduate University of the Chinese Academy of Sciences, Beijing 100039, China | 2007 | Science China Earth Sciences2007，50，3： | 9 |
| 2 | Relation of ice conditions to climate change in the Bohai Sea of China显示文摘The ice conditions in the Bohai Sea and the northern Huanghai Sea greatly change from year to year with winter climate. Ice only covers below 15% of the the waters during the wannest win-ter, while it covers more than 80% during the coldest winter. Ice observation and data acquisition are outlined in the paper. The ice-covered area, the position of ice edge and the ice grades give indication of the ice conditions. The local climate of the waters can be expressed by using the air temperature of the stations of Dalian and Yingkou. The variation of the ice condition indexes with the monthly mean air temperature at Dalian from 1952 to 2000 is shown, as well. The local climate and ice conditions in the waters are affected by many factors,such as, evolution of the general atmospheric circulation and the solar activity. The delayed correlation between the ice conditions and lots of the affecting factors is analysed in the paper. The ice conditions are continuously mild since the 1990s, that is relative to the tendency of the global warming. The ice condition variation of the Bohai Sea is related to the El Nino event and the sunspot period. The seasonal evolution of the ice conditions is also described in the paper. | Bai Shan, Liu Qinzheng, Wu Huiding I. National Center fOr Marine Environmnt FOrecats, ffeijing l(XX)8I. China. | 2001 | Acta Oceanologica Sinica2001，20，3： | 7 |
| 3 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 4 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 5 | Genetic algorithms for optimal placement of phasor measurement units in electrical networks 显示文摘 | MARIN F J GARCIA L | 2003 | Eleetronies Letters2003，39，19： | 1 |
| 6 | Normal Spinal Bone Marrow in Adult:Dynamic Gadolinium-enhanced MR Imaging显示文摘 | Jean M Marine D Eric L | 2003 | Radiology2003，229，： | 1 |
| 7 | Determination of adipate plasticizers in poly(vinyl chloride) by microwave- assisted extraction 显示文摘 | J M Cano M L Marin A Sanchez | 2002 | Journal of Chromatography A2002，963，： | 1 |
| 8 | Design and simulation of an industrial automated overhead warehouse显示文摘 | Marin RM Garrido J Trillo J L | 1998 | Integrated Manufacturing System1998，，95： | 1 |
| 9 | 'I Need You Too!' Corporate Identity Attrac- tiveness for Consumers and the Role of Social Responsibility显示文摘 | Marin L Ruiz S | 2007 | Journal of Business Ethics2007，71，3： | 1 |
| 10 | Exposure of the clam Tapes phillpplnarum to 4-nonylphenol : changes in anti-oxidant en- zyme activities and rc-burrowing capability 显示文摘 | MATOZZO V BALLARIN L MARIN M G | 2004 | Mar Pollut Bull2004，48，56： | 1 |
| 11 | Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span显示文摘 | Azziz R Marin C Hoq L | 2005 | Clin Endocrinol Metab2005，90，1： | 1 |
| 12 | Poly (AT) polymorphism in intron 11 of the XPC DNA repair gene enhances the risk of lung cancer显示文摘 | Marin MS Lopez-Cima MF Garcia-Castro L | 2004 | Cancer Epidemiol Biomarkers Prey2004，13，11： | 1 |
| 13 | Health care related economic burden of the polycystic ovary syndrome during the reproductive life span显示文摘 | AZZIZ R MARIN C HOQ L | 2009 | J Clin Endocrinol Metab2009，90，8： | 1 |
| 14 | The role of identity salience in the effects of corporate social responsibility on consumer behavior显示文摘 | Marin L Ruiz S and Rubio A | 2009 | Journal of Business Ethics2009，84，1： | 1 |
| 15 | Implication of soluble and membrane HLA class Ⅰ and serum IL-10 in liver graft acceptance显示文摘 | Minguela A Torio A Marin L | 1999 | Hum Immunol1999，60，6： | 1 |
| 16 | Liver recipients harbouring anti-donor preformed lymphocytotoxic antibodies exhibit a poor allograft survival at the first year after transplantation:experience of one centre显示文摘 | Muro M Marin L Miras M | 2005 | Transpl Immunol2005，14，2： | 1 |
| 17 | An extended Kalman filter for quaternion-based orientation estimation using MARG sensors显示文摘 | Marins J L Yun X Bachmarm E R | 2001 | IEEE Conference of Intelligent Robots and Systems Maui Hawaii USA2001，2001，4： | 1 |
| 18 | Electro-oxidation of ammonia in wastewater显示文摘 | Mariner L Lectz F B | 1978 | J Appl Electrochem1978，8，： | 1 |
| 19 | Review on thermal energy storage with phase change:materials,heat transfer analysis and application显示文摘 | Zalba B Marin J M Caberza L F | | 0，，03： | 1 |
| 20 | Early and lateonset ventilator associated pneumonia acquired in the intensive careunit:comparison of risk factors显示文摘 | Marine G Alain L Bernard A | | 0，，01： | 1 |
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