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| 1 | Cancer Immunotherapy Targeting the Telomerase Reverse Transcriptase显示文摘人的 telomerase 颠倒 transcriptase (hTERT ) 在超过 85% 肿瘤房间被表示,但是通常没在正常房间被发现,它作为理想的肿瘤伙伴抗原(TAA ) 做 hTERT 开发没有在人的癌症免疫疗法损害正常纸巾,明确地破坏癌症的潜在的疫苗。这被考察 hTERT 或它的肽和早临床的 trials using 的 immunogenicity 上的研究的基本进展在最后十年的 hTERT 疫苗途径。 | Longfei Huo Janice WS Tang Junjian Huang Peitang Huang Cuifen Huang Hsiang-fu Kung Marie C. Lin | 2006 | Cellular & Molecular Immunology2006，3，1： | 4 |
| 2 | Artificial cold exposure induced stroke in renovascular hypertensive rats and its association with cold-inducible RNA binding protein mRNA expression in brain tissue and blood pressure显示文摘BACKGROUND: High incidence of stroke at interchange period of autumn and winter was demonstrated by epidemiological survey, and the specific causes should be further investigated. OBJECTIVE: To investigate the influence of artificial cold exposure on the incidence of stroke in renovascular hypertensive rats (RHR), and analyze the association with blood pressure and cold-inducible RNA binding protein (CIRP) mRNA expression in brain tissue. DESIGN: A completely randomized grouping design, a randomized control animal trial. SETTINGS: Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University; Department of Chemistry, Open laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong. MATERIALS: Male SD rats (n =460), weighing 80-100 g were obtained from Guangdong Province Health Animal Unit. A modified RXZ-300A intelligent artificial climate cabinet (Ningbo Jiangnan Instrument Co.,Ltd., China). METHODS: The experiment were processed in the Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University and the Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong from October 2004 to November 2005. Rats (n = 400) were operated to establish 2-kidney 2-clip RHR model as described previously. The sham-operated rats (n =60) served as normotensive controls. Eight weeks later, 300 of RHR were randomly selected according to their systolic blood pressure (SBP) and divided into 3 sub-groups (n =100 per group): mild hypertensive group (SBP of 160-200 mm Hg), moderate hypertensive group (SBP of 200-220 mm Hg) and severe hypertensive group (SBP > 220 mm Hg). Each group was further divided into two groups (n =50) under ACE and non-ACE. Normal sham-operated SD rats (n =60), SBP < 140 mm Hg, were randomly divided into two groups: Sham-operated control group (n =30) under ACE and non-ACE. To establish the ACE and non-ACE treatment, rats were housed individually in artificial climate cabinet, and ACE was designed as three cycles of 12-hour light of 22 ℃ (7∶00-19∶00) and 12-hour dark of 4 ℃(19∶00-7∶00). The non-ACE group was kept at 22 ℃ throughout the experiment. MAIN OUTCOME MEASURES: Blood Pressure changes were measured and stroke symptom were observed; Expression of the CIRP were examined by reverse transcription-polymerase chain reaction. RESULTS: Finally 360 rats were involved in the analysis of results. ① Incidence of stroke: The incidence of stroke in 2k2c RHR was significantly higher after a three-day intermittent (12-hour) ACE (29.3%) as compared with that in non-ACE (17.3%) (P < 0.05). Furthermore, the severe hypertensive 2k2c RHR (BP > 220 mm Hg) was found to have much higher incidence of stroke (66%, 33/50) than the mild (8%, 4/50) and moderate (18%) hypertensive 2k2c RHR. ② CIRP mRNA in brain tissue: ACE treatment stimulated the mRNA expression of CIRP in non-stroke 2k2c RHR but not in stroke 2k2c RHR (P < 0.05). CONCLUSION: High blood pressure and low expression of CIRP are associated with ACE induced stroke. | Xiaoaena Shi Jianwen Lin Ying Peng Lally L.K. Chan Hsiang Fu Kung Marie C. Lin Ruxun Huang | 2007 | Neural Regeneration Research2007，2，8： | 2 |
| 3 | The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat显示文摘 | Bing Liang Ming-Liang He Chu-yan Chan Yang-chao Chen Xiang-Ping Li Yi Li Dexian Zheng Marie C. Lin Hsiang-Fu Kung Xin-Tao Shuai Ying Peng | 2009 | Biomaterials2009，，23： | 1 |
| 4 | Chronic Alcohol Consumption Accelerates Fibrosis in Response to Cerulein-Induced Pancreatitis in Rats显示文摘 | Xiaoying Deng Lin Wang Mary S. Elm David Gabazadeh Greg J. Diorio Patricia K. Eagon David C. Whitcomb | 2005 | The American Journal of Pathology2005，，1： | 1 |
| 5 | Chronic Alcohol Consumption Accelerates Fibrosis in Response to Cerulein-Induced Pancreatitis in Rats显示文摘 | Xiaoying Deng Lin Wang Mary S. Elm David Gabazadeh Greg J. Diorio Patricia K. Eagon David C. Whitcomb | 2005 | The American Journal of Pathology2005，，1： | 1 |
| 6 | MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells显示文摘 | Hongping Xia Yanting Qi Samuel S. Ng Xiaona Chen Shen Chen Marong Fang Dan Li Yu Zhao Ruiguang Ge Guo Li Yangchao Chen Ming-Liang He Hsiang-fu Kung Lihui Lai Marie C. Lin | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 7 | microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs显示文摘 | Hongping Xia Yanting Qi Samuel S. Ng Xiaona Chen Dan Li Shen Chen Ruiguang Ge Songshan Jiang Guo Li Yangchao Chen Ming-Liang He Hsiang-fu Kung Lihui Lai Marie C. Lin | 2008 | Brain Research2008，，： | 1 |
| 8 | MicroRNA expression profiles and functions in the brain显示文摘MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates. | Yanting Qi Yu Zhao Zhuyin Chen Xiaona Chen Marie C. Lin Xiangfu Kong Lihui Lai | 2008 | Neural Regeneration Research2008，3，12： | 0 |
| 9 | 急性卒中影像学研究路径图Ⅱ显示文摘卒中影像学研究组(StrokeImagingResearchGroup,STIR)、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议,最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议(Stroke Treatment Academy Industry Roundtable,STAIR)期间举行。 | Max Wintermark Gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden Grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip M. White Greg Zaharchuk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs Gotz Thomalla Steven J. Warach 严晓铭 刘牧 张晶晶 柯开富 | 2014 | 国际脑血管病杂志2014，22，2： | 0 |
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