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| 1 | Nosocomial colonization due to imipenem-resistant Pseudomonas aeruginosa epidemiologically linked to breast milk feeding in a neonatal intensive care unit显示文摘瞄准:我们描述殖民的一个年调查由 imipenem 抵抗,在巴勒莫的大学医院的一个新生的特别护理单位(NICU ) 生产 Pseudomonas aeruginosa 的 metallo-β-lactamase (MBL ) ,意大利。方法:未来的流行病学的调查在时期被进行 2003 1 月到 2004 1 月。直肠的拖把一个星期在整个他们的 NICU 停留从所有出生不满一月的婴儿被收集两次。由 P aeruginosa 的 imipenem 抵抗的紧张的 MBL 生产被 phenotypic 和分子的方法检测。搏动的地胶化电气泳动(PFGE ) 在所有上被执行 P 孤立 aeruginosa。在由 imipenem 抵抗的、 imipenem 易受影响的 P 的风险因素和 aeruginosa 孤立的殖民和另外的 multidrug 抵抗的克之间的协会否定(MDRGN ) 有机体为在承认并且在 NICU 停留期间在场的变量被分析。数据分析被艇长执行比例的危险回归模型。结果:210 个出生不满一月的婴儿中的 22 个被开拓殖民地于与 imipenem 抵抗,生产 MBL P aeruginosa 孤立, 14 由 imipenem 易受影响的 P aeruginosa 孤立。单个 pulsotype,命名 A,被 imipenem 抵抗的所有分享孤立。由 pulsotype A 的 P aeruginosa 的殖民断然被相关,母奶和 ampicillin-sulbactam 的管理喂,并且相反地与由公式的独占的喂相关。在艇长,比例的危险回归模型,超过 2500 g 的出生重量并且母奶喂是独立地由生产 MBL P aeruginosa.Conclusion 与殖民的增加的风险联系了:结果强烈支持在殖民之间的一个协会由一明确 imipenem 抵抗,喂的 MBL 生产 P aeruginosa 紧张和母奶。如此的研究可以加亮需要让策略的实现阻止表示母奶成为健康的车辆联系照顾的感染。 | Caterina MAMMINA Paola DI CARLO Domenico CIPOLLA Alessandra CASUCCIO Matilde TANTILLO MariaRosa Anna PLANO Angela MAZZOLA1, Giovanni CORSELLO | 2008 | Acta Pharmacologica Sinica2008，29，12： | 11 |
| 2 | Spleen stiffness mirrors changes in portal hypertension after successful interferon-free therapy in chronic-hepatitis C virus patients显示文摘AIM To investigate changes in spleen stiffness measurements(SSMs) and other non-invasive tests(NITs) after treatment with direct-acting antivirals(DAAs) and identify predictors of SSM change after sustainedvirological response(SVR). METHODS We retrospectively analysed 146 advanced-chronic liver disease(ACLD) patients treated with DAA with available paired SSM at baseline and SVR24. Liver stiffness(LSM), spleen diameter(SD), platelet count(PLT) and liver stiffness-spleen diameter to platelet ratio score(LSPS) were also investigated. LSM ≥ 21 k Pa was used as a cut-off to rule-in clinically significant portal hypertension(CSPH). SSM reduction > 20% from baseline was defined as significant.RESULTS SSM significantly decreased at SVR24, in both patients with and without CSPH; in 44.8% of cases, SSM reduction was > 20%. LSPS significantly improved in the entire cohort at SVR24; SD and PLT changed significantly only in patients without CSPH. LSM significantly decreased in 65.7% of patients and also in 2/3 patients in whom SSM did not decrease. The independent predictor of decreased SSM was median relative change of LSM. CSPH persisted in 54.4% patients after SVR. Delta LSM and baseline SSM were independent factors associated with CSPH persistence.CONCLUSION SSM and other NITs significantly decrease after SVR, although differently according to the patient's clinical condition. SSM faithfully reflects changes in portal hypertension and could represent a useful NIT for the follow-up of these patients. | Federico Ravaioli Antonio Colecchia Elton Dajti Giovanni Marasco Luigina Vanessa Alemanni Mariarosa Tamè Francesco Azzaroli Stefano Brillanti Giuseppe Mazzella Davide Festi | 2018 | World Journal of Hepatology2018，10，10： | 3 |
| 3 | Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis显示文摘 | Cristina Giannattasio MariaRosa Pozzi Marco Gradinali Elisabetta Montemerlo Francesca Citterio Silvia Maestroni Elena Fantini Monica Failla Maria Robuschi Salvatore Bianco Giuseppe Mancia | 2007 | Journal of Hypertension2007，，4： | 2 |
| 4 | II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: Co-milling显示文摘 | Lauretta Maggi Giovanna Bruni Mariarosa Maietta Andrea Canobbio Andrea Cardini Ubaldo Conte | 2013 | International Journal of Pharmaceutics2013，，： | 1 |
| 5 | Effects of prostaglandin E1α cyclodestrin treatment on endothelial dysfunction in patients with systemic sclerosis显示文摘 | Cristina Giannattasio MariaRosa Pozzi Marco Gradinali Elisabetta Montemerlo Francesca Citterio Silvia Maestroni Elena Fantini Monica Failla Maria Robuschi Salvatore Bianco Giuseppe Mancia | 2007 | Journal of Hypertension2007，，4： | 1 |
| 6 | 17‐B estradiol elicits an autocrine leiomyoma cell proliferation: Evidence for a stimulation of protein kinase‐dependent pathway显示文摘 | AlfonsoBarbarisi OrsolinaPetillo AndreaDi Lieto Mariarosa A.B.Melone SabrinaMargarucci MarioCannas GianfrancoPeluso | 2001 | J Cell Physiol2001，，3： | 1 |
| 7 | Long-term antiviral treatment for recurrent hepatitis C after liver transplantation显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Maria Cristina Morelli Paolo Di Gioia Mariarosa Tamè Stefania Lorenzini Pietro Andreone Giorgio Ercolani Massimo Del Gaudio Matteo Ravaioli Alessandro Cucchetti Alessandro Dazzi Antonietta D’Errico-Grigioni Antonio Da | 2012 | Digestive and Liver Disease2012，，10： | 1 |
| 8 | Beclomethasone microparticles for wet inhalation,produced by supercritical assisted atomization显示文摘 | Ernesto Reverchon Renata Adami Mariarosa Scognamiglio | 2010 | Industrial&Engineering Chemistry Research2010，49，12： | 1 |
| 9 | Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells显示文摘 | Francesco P.Jori Marco A.Napolitano Mariarosa A.B.Melone MarilenaCipollaro AntoninoCascino LuciaAltucci GianfrancoPeluso AntonioGiordano UmbertoGalderisi | 2005 | J. Cell. Biochem2005，，4： | 1 |
| 10 | Nimesulide adsorbed on silica aerogel using su- percritical carbon dioxide显示文摘 | Giuseppe Caputo Mariarosa SeognamigIin Iolanda De Marco | 2012 | Chemical Engineering Re- search and Design2012，90，8： | 1 |
| 11 | Oxyresveratrol ( trans -2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia显示文摘 | Shaida A Andrabi Mariarosa G Spina Peter Lorenz Uwe Ebmeyer Gerald Wolf Thomas F.W Horn | 2004 | Brain Research2004，，1： | 1 |
| 12 | Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor’s proangiogenic microenvironment显示文摘 | Antonietta Silini Carmen Ghilardi Sara Figini Fabio Sangalli Robert Fruscio Regine Dahse R. Barbara Pedley Raffaella Giavazzi MariaRosa Bani | 2012 | Cellular and Molecular Life Sciences2012，，7： | 1 |
| 13 | Nasal continuous positive air-way pressure with heliox in preterm infants with respiratory distress syndrome显示文摘 | Mariarosa C Maria P Claudio M | | 0，，： | 1 |
| 14 | Narrative Discourse and Sociocognitive Abilities of a Child With Cri-du-Chat Syndrome显示文摘 | Stefania Albano Laura Piccardi MariaRosa Pizzamiglio Cristino Volpe Simonetta D’Amico | 2013 | The Journal of Genetic Psychology2013，，1： | 1 |
| 15 | Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system 显示文摘 | Mario C Dario V Mariarosa M | 2003 | Journal of Controlled Release2003，88，3： | 1 |
| 16 | Long-term leukocyte natural α-interferon and ribavirin treatment in hepatitis C virus recurrence after liver transplantation显示文摘AIM:To evaluate the effect of long-term treatment with leukocyte natural-interferon(ln-α-IFN)plus ribavirin(RBV).METHODS:Forty-six patients with hepatitis C virus(HCV)recurrence received 3 MU three times a week of ln-α-IFN plus RBV for 1 mo;then,patients with good tolerability(n=30)were switched to daily IFN administration,while the remaining were treated with the same schedule.Patients have been treated for 12 mo after viral clearance while non-responders(NR)entered in the longterm treatment group.Liver biopsies were planned at baseline,1 year after sustained virological response(SVR)and at 36 mo after start of therapy in NR.MedCalc software package was used for statistical analysis.RESULTS:About 16.7%of genotype 1-4 and 70%of genotype 2-3 patients achieved SVR.Nine patients withdrew therapy because of non-tolerance or noncompliance.A significant improvement in serum biochemistry and histological activity was observed in all SVR patients and long-term treated;100%of patients with SVR achieved a histological response(fibrosis stabilization or improvement)with a significant reduction in mean staging value(from 2.1 to 1.0;P=0.0031);histological response was observed in 84%of long-term treated patients compared to 57%of drop-out.Six patients died during the entire study period(follow-up 40.6±7.7 mo);of them,5 presented with severe HCV recurrence on enrollment.Diabetes(OR=0.38,95%CI:0.08-0.59,P=0.01),leukopenia(OR=0.54,95%CI:0.03-0.57,P=0.03)and severe HCV recurrence(OR=0.51,95%CI:0.25-0.69,P=0.0003)were variables associated to survival.Long-term treatment was well tolerated;no patients developed rejection or autoimmune disease.CONCLUSION:Long-term treatment improves histology in SVR patients and slows disease progression also in NR,leading to a reduction in liver decompensation,graft failure and liver-related death. | Mariarosa Tamè Federica Buonfiglioli Massimo Del Gaudio Andrea Lisotti Paolo Cecinato Antonio Colecchia Francesco Azzaroli Antonietta D’Errico Rosario Arena Claudio Calvanese Chiara Quarneti Giorgio Ballardini Antonio Daniele Pinna Giuseppe Mazzella | 2013 | World Journal of Gastroenterology2013，19，32： | 0 |
| 17 | Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: A prospective study on patients with HCV related cirrhosis显示文摘AIM: To determine the role of interferon (IFN) with or without ribavirin in preventing or delaying hepatocellular carcinoma (HCC) development in patients with hepatitis C virus (HCV) related cirrhosis. Data on the preventive effect of IFN plus ribavirin treatment are lacking.METHODS: A total of 101 patients (62 males and 39 females, mean age 55.1:1:1.4 years) with histologically proven HCV related liver cirrhosis plus compatible biochemistry and ultrasonography were enrolled in the study. Biochemistry and ultrasonography were performed every 6 too. Ultrasound guided liver biopsy was performed on all detected focal lesions. Follow-up lasted for 5 years. Cellular proliferation, evaluated by measuring Ag-NOR proteins in hepatocytes nuclei, was expressed as AgNOR-Proliferative index (AgNOR-PI) (cut-off = 2.5). Forty-one patients (27 males, 14 females) were only followed up after the end of an yearly treatment with IFN-alpha2b (old treatment control group = OTCG). Sixty naive patients were stratified according to sex and AgNOR-PI and then randomized in two groups: 30 were treated with IFN-alpha2b + ribavirin (treatment group=TG), the remaining were not treated (control group=CG). Nonresponders (NR) or relapsers in the TG received further IFN/ribavirin treatments after a 6 mo of withdrawal. RESULTS: AgNOR-PI was significantly lowered by IFN (P<0.001). HCC incidence was higher in patients with AgNOR-PI>2.5 (26% vs3%, P<0.01). Two NR in the OTCG, none in the TG and 9 patients in the CG developed HCC during follow-up. The Kaplan-Mayer survival curves showed statistically significant differences both between OTCG and CG (P<0.004) and between TG and CG (P<0.003). CONCLUSION: IFN/ribavirin treatment associated with retreatment courses of NR seems to produce the best results in terms of HCC prevention. AgNOR-PI is a useful marker of possible HCC development. | Francesco Azzaroli Esterita Accogli Giovanni Nigro Davide Trerè Silvia Giovanelli Anna Miracolo Francesca Lodato Marco Montagnani Mariarosa Tamé Antonio Cloecchia Constance Mwangemi Davide Festi Enrico Roda Massimo Derenzini Giuseppe Mazzella | 2004 | World Journal of Gastroenterology2004，10，21： | 0 |
| 18 | 湍流与张力 巴奴概念餐厅显示文摘巴奴概念餐厅是一个设计面积2100 m2的室内改造项目,位于河南郑州。巴奴火锅是一家新兴的餐饮企业,在中国已有56家直营店,本项目作为该企业的旗舰店,将是塑造企业形象的重要门户。“巴奴”一名取自木船航运时代的川江纤夫,他们用自己的身体承载着川江水路的千万民生,这种在风雨里坚持向前的精神也是巴奴企业最重要的文化核心。设计师提取了有关纤夫与河流的两个重要标识,将其抽象为“湍流的空间”和“有张力的绳索”。 | 无 Ted Kane(Kane AUD) Sanhoi Lam(Kane AUD) Viviana Wang Mariarosa Doardo 陈晨 吴清山(摄影) | 2020 | 室内设计与装修2020，，9： | 0 |
| 19 | Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells显示文摘BACKGROUND Research on physiopathology of obesity may receive new hints from studies on skinny people(SP). These are individuals who show a poor or null gaining of body weight, in spite of high-calorie intake, by far exceeding the body requirements.AIM To evaluate how circulating factors present in the SP sera may affect adipogenesis of mesenchymal stromal cells(MSCs).METHODS We isolated MSCs from bone marrow of healthy donors with both normal body mass index(BMI) and caloric consumption. MSC cultures were primed with sera collected from SP or normal people(NP). Then biomolecular assays were performed to evaluate effect on proliferation, apoptosis, senescence, cell commitment, and differentiation.RESULTS SP priming affected adipocyte cell commitment and reduced spontaneous adipogenesis. Moreover, an in-depth analysis of exogenous-induced adipocyte differentiation showed striking differences between differentiation in SP-primed samples compared with NP ones. In adipocytes from SP cultures we observed a reduced size of lipid droplets, an increased expression of adipose triglyceride lipase, along with high mitochondria content and ability to produce ATP in starvation condition. These data and the expression of UCP1 protein, indicated that SP pretreatment produced a bias toward brown adipocyte differentiation.CONCLUSION Our data suggest that sera from SP may promote brown adipogenesis rather that white adipocyte differentiation. This finding could explain why SP present normal body composition in spite of an excess of caloric intake. We hypothesize that some circulating components present in the blood of these individuals may favor brown adipogenesis at expense of white adipocyte production. | Nicola Alessio Tiziana Squillaro Vincenzo Monda Gianfranco Peluso Marcellino Monda Mariarosa AB Melone Umberto Galderisi Giovanni Di Bernardo | 2019 | World Journal of Stem Cells2019，11，3： | 0 |
| 20 | 深圳南山外国语学校科华学校显示文摘深圳南山外国语学校科华学校是一座总建筑面积为54,000m^2的九年一贯制学校,包含中小学教室、各类专业教室、图书馆、体育馆、游泳馆、演艺报告厅、教师宿舍楼、中小学学生餐厅、教师餐厅以及专业运动操场等。学校位于深圳大冲区,是长达十年的大冲旧改项目的最后一片拼图,见证了此区域从密集的“城中村”到城市化的“垂直森林”的变迁。被周边高密度、超高层商业住宅所包围的场地,面临着在当代中国过度城市化进程中,将破碎的城市肌理重新缝合的挑战。 | 无 Kenneth Namkung Dongyul Kim Hyungsun Choi 邓一泓 刘婧 Yoko Fujita 秦思梦 梅富鹏 闵嘉剑 郭奕爽 王骞 Mariarosa Doardo 袁佳琳 钱文韵 温馨卉 高晴月 苏圣亮(摄影) | 2020 | 建筑实践2020，3，5： | 0 |
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