3篇
您的检索式：作者名="Maria Lamar"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor biopsy and patient enrollment in clinical trials for advanced hepatocellular carcinoma显示文摘Tumor biopsies may help to reliably distinguish hepatocellular carcinoma(HCC) from other tumors, mostly cholangiocarcinoma as well as to identify the patient populations who most benefit from target-driven HCC treatments, in order to improve the success rate of experimental therapies. Clarifying tumor biology may also lead to identify biomarkers with prognostic role and/or enabling to predict response or resistance to therapies. Recently, clinical trials have more efficiently included biomarker endpoints and increasingly collected tumor tissue from enrolled patients. Due to their frail status and sometimes fast-progressing disease, the performance status of patients with HCC progressing on first-line therapy can deteriorate quickly, preventing their enrollment in clinical trials. However, the challenge of identifying the proper patient at the proper time can be overcome by periodic inter-department meetings involving the key specialists taking care of HCC patients, and solid networks between research centers and referring institutions. An early planned biopsy would also facilitate timely inclusion of patients in biology-driven clinical trials. Ultimately, institution of multidisciplinary teams can optimize treatment choice, biopsy timing, and quick enrollment of patients in clinical trials, before their performance status deteriorates. | Lorenza Rimassa Maria Reig Giovanni Abbadessa Markus Peck-Radosavljevic William Harris Vittorina Zagonel Davide Pastorelli Elena Rota Caremoli Camillo Porta Nevena Damjanov Hitendra Patel Bruno Daniele Maria Lamar Brian Schwartz Terri Goldberg Armando Santoro Jordi Bruix | 2017 | World Journal of Gastroenterology2017，23，13： | 1 |
| 2 | Geographic information systems and the environmental risk of schistosomiasis in BAHIA,BRAZIL 显示文摘 | Lamar FH John BM | 1999 | Am J Trop Med Hyg1999，60，4： | 1 |
| 3 | Establishment and conventional cytogenetic characterization of three gastric cancer cell lines显示文摘 | Mariana Ferreira Leal José Luiz Martins do Nascimento Carla Elvira Araújo da Silva Maria Fernanda Vita Lamar?o Danielle Queiroz Calcagno André Salim Khayat Paulo Pimentel Assump??o Isabel Rosa Cabral Marília de Arruda Cardoso Smith Rommel Rodríguez Burban | 2009 | Cancer Genetics and Cytogenetics2009，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员