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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 3 | Phthalates determination in pharmaceutical formulae used in parenteral nutrition by LC-ES-MS: Importance in public health 显示文摘 | Cristina P F Maria C B A Antia S D | 2010 | Analytical and Bioanalytieal Chemistry2010，397，2： | 1 |
| 4 | MCM41 functionalized with ethylenediaminetriacetic acid for ion-exchange chromatography 显示文摘 | Maria C B Corrado S Anna M T | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 5 | Alternative nuclear functions for NF-KB family members显示文摘 | Llufs E Anna B Maria C M | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 6 | Characterisation and modelling of oscillatory behaviour related to reuterin production by Lactobacillus reuteri显示文摘 | Maria R Gary C B Kolja S | 2002 | International Journal of Food Microbiology2002，73，： | 1 |
| 7 | Mandarin peel wastespretreatment with steam explosion for bioethanol production显示文摘 | MARIA B A LIDIA G V FAYINY P G C | 2010 | Bioresource Technology2010，101，10： | 1 |
| 8 | Review of procedures involving sep- aration and preeoncentration for the determination of cadmium using spectrometric techniques 显示文摘 | Ferreira Srgio L C de Andrade Jailson B Korn Maria das Gracas A | 2007 | Journal of Hazardous Materials2007，145，3： | 1 |
| 9 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 10 | Aerobic denitrification bacteria that produce low levels of nitrous oxide显示文摘 | Takaya N Maria Antonina B C S Yasushi S | 2003 | Appl Envir Microbio2003，69，6： | 1 |
| 11 | Filled snack production by coextrusion cooking: effect of processing on cereal mixtures显示文摘 | Cindio B Gabriele D Maria Pollini C | 2002 | Journal of Food Engineering2002，54，1： | 1 |
| 12 | Cochlear implanted children present vocal parameters within normal standards显示文摘 | LOURDES B R DE S MARIA C B ALCIONE GB | 2012 | Int J Pediatric Otolaryngol2012，76，： | 1 |
| 13 | Analytical procedures for the determination of organotin compounds in sediment and biota : a critical review 显示文摘 | Manuela A Josep- Maria B Ramom C | 1997 | Analytiea Chemica Acta1997，，788： | 1 |
| 14 | Neoformation of antioxidants in glycation model systems treated under subcriticalwater extraction conditions 显示文摘 | Merichel P Miryam A B Maria D C | 2010 | Food Research International2010，43，： | 1 |
| 15 | Introduction of the family Alloherpesviridae: the first molecuLar detection of herpesviruses of cyprinid fish in Hungary 显示文摘 | Andor D Maria B Gyoergy C | 2011 | Magyar Allatorvosok Lapja2011，133，3： | 1 |
| 16 | Almeida e Silva, Response surface methodology for xylital production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rita C L B Rodrigues Maria das Gracas A Felipe Joao B | 2003 | Process Biochemistry2003，38，： | 1 |
| 17 | A simplified thermal model for variable-speed self-cooled industrial induction motor显示文摘 | ALDO B ANDREA C MARIA L | 2003 | IEEE Transactions Industry Applications2003，39，4： | 1 |
| 18 | Abatement and allocation in the pilot phase of the EU ETS 显示文摘 | Anderson B Maria C D | 2011 | Environmental & Resource Economics2011，48，1： | 1 |
| 19 | Pro up regulation: a diagn illicit use of oestrog ens in adult beef cattle显示文摘 | Divari S Mulasso C Spada F De Maria R gesterone receptor ostic tool for the Uslenghi F Cannizzo FT Brina N Biolatti B | 2011 | Tumour Biol2011，28，12： | 1 |
| 20 | Characterization of the behaviour of flavour microcapsules in cotton fabrics 显示文摘 | Pablo M Maria A B Francisco C | 2007 | European Polymer Journal2007，43，6： | 1 |
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