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| 1 | Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions显示文摘·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with radiotherapy.Thirty-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions. | Lukas Reznicek Carmen Stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer Marcus Kernt | 2014 | International Journal of Ophthalmology(English edition)2014，7，4： | 3 |
| 2 | Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation显示文摘Treatment of physeal fractures(15%–30%of all paediatric fractures)remains a challenge as in approximately 10%of the cases,significant growth disturbance may occur.Bioresorbable Magnesium-based implants represent a strategy to minimize damage(i.e.,load support until bone healing without second surgery).Nevertheless,the absence of harmful effects of magnesium-implants and their degradation products on the growth plate should be confirmed.Here,the proteome of human mesenchymal stem cells undergoing chondrogenesis was evaluated when exposed to the products of various Magnesium-based materials degradation.The results of this study indicate that the materials induced regulation of proteins associated with cell chondrogenesis and cartilage formation,which should be beneficial for cartilage regeneration. | Adela Helvia Martínez Sánchez Maryam Omidi Marcus Wurlitzer Marceline Manka Fuh Frank Feyerabend Hartmut Schlüter Regine Willumeit-Römer Bérengère J.C.Luthringer | 2019 | Bioactive Materials2019，4，1： | 2 |
| 3 | Challenges for land system science显示文摘 | Mark D.A. Rounsevell Bas Pedroli Karl-Heinz Erb Marc Gramberger Anne Gravsholt Busck Helmut Haberl S?ren Kristensen Tobias Kuemmerle Sandra Lavorel Marcus Lindner Hermann Lotze-Campen Marc J. Metzger David Murray-Rust Alexander Popp Marta Pérez-Soba Anett | 2012 | Land Use Policy2012，，4： | 2 |
| 4 | Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy显示文摘AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic retinopathy.METHODS: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was included.Leak-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic location.Leaking was defined by late phase fluorescein angiograms compared to early phase.Retinal thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm circle.RESULTS: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,respectively.CONCLUSION: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution OCT.Therefore,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening. | Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer | 2011 | International Journal of Ophthalmology(English edition)2011，4，3： | 2 |
| 5 | Determination of malachite green residues in fish using molecularly imprinted solid-phase extraction followed by liquid chromatography–linear ion trap mass spectrometry显示文摘 | María Jesús Martínez Bueno Sonia Herrera Ana Uclés Ana Agüera María Dolores Hernando Olga Shimelis Marcus Rudolfsson Amadeo R. Fernández-Alba | 2010 | Analytica Chimica Acta2010，，1： | 2 |
| 6 | Extrauterine Pregnancy resulting from ea rly uterine显示文摘 | Cheng E Goff B | 1999 | Obstet Gynecol1999，94，52： | 1 |
| 7 | Assessing landslide potential using GIS, soil wet -ness modeling and topographic attributes, Payene River, Idaho 显示文摘 | Lineback G M Marcus W A Aspinall R Custer S G | 2001 | Geomorphology2001，37，： | 1 |
| 8 | Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms 显示文摘 | RAINER K GUNNAR S MARCUS O | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 9 | Fracture Strength of 5Different All-Ceramic Crown Systems 显示文摘 | Jorg R Strub S Marcus Beschnidt | 1998 | J Prosthet Dent1998，，11： | 1 |
| 10 | Elastic moduli and hardness of cubic silicon nitride显示文摘 | ANDREAS Z MARKUS K MARCUS S | 2002 | J Am Ceram Soc2002，85，1： | 1 |
| 11 | Treatment strategies and results in spinal vascular malformations显示文摘 | Beate CH Uwe S Marcus R | 1998 | Neurol Med Chir Suppl(Toky- o)1998，38，： | 1 |
| 12 | Incorporation of alkoxysilanes into model latex systems: viny copolymerizatio,a of vinyltriethoxysilane and n-butyl acrylate 显示文摘 | Marcu I Daniels E S Dimonie V L | 2003 | Macromolecules2003，36，： | 1 |
| 13 | Optimal management of the pancreatic remnant after pancreaticoduodenectomy显示文摘 | Marcus S Cohen H Ranson J | 1995 | Ann Surg1995，221，6： | 1 |
| 14 | Recurrent laryngeal nerve monitoring in thyroid and paralhyroid surgery : the University of Michigan experience显示文摘 | Marcus B Edwards B Yoo S | 2003 | Laryngoscope2003，113，： | 1 |
| 15 | Inhibition of apoptosis after ischemia reperfusion in rat myocardium by cycloheximide显示文摘 | Musat Marcu S Gunter HE Jugdutt BI Docherty JC | | 0，，： | 1 |
| 16 | Overregularization in language acquisition显示文摘 | Marcus G F Pinker S Ullman M | 1992 | Monographs of the Society for Research in Child Development1992，57，4： | 1 |
| 17 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 18 | Analysis of a risk-sensitive control problem for hidden Markov chains显示文摘 | Hernandez-Hernandez D Marcus S I Fard P J | 1999 | IEEE Transactions on Automatic Control1999，44，5： | 1 |
| 19 | Observations of First-Order Liquid-to-Hexatic and Hexatic-to-Solid Phase Transitions in a Confined Colloid Suspension显示文摘 | MARCUS A H RICE S A | 1996 | Phys Rev Lett1996，77，12： | 1 |
| 20 | High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update 显示文摘 | George RE Li S Medeiros-Nancarrow C Neuberg D Marcus K Shamberger RC | 2006 | J Clin Oncol2006，24，18： | 1 |
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