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| 1 | Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery显示文摘AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.METHODS: A prospective and controlled trial including a large cohort of 1650 individuals suffering with bilateral cataract not complicated, in program by phacoemulsification surgery, were randomly assigned to 2 different groups for the type of anesthesia received, 0.4% oxybuprocaine hydrochloride(INN) drops, and INN drops associated to intracameral 1% lidocaine hydrochloride monohydrate. At the end of surgery, tables were assigned to each patient indicating the degree of pain(0-3) felt during the operation.RESULTS: Thirty-two percent of patients in group 1 declared to have not felt any pain against the 77% of patients in group 2. Fifty-nine percent of patients in group 1 complained about only a slight discomfort against 20% of group 2 patients. Only a small percentage of patients in group 1(5%) admitted severe pain, while no patient in group 2 admitted severe pain. Four patients of group 2 reported an episode of transient amaurosis, lasting several hours after surgery.CONCLUSION: Intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation. | Marcella Nebbioso Maria Luisa Livani Valentina Santamaria Aloisa Librando Massimiliano Sepe | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 3 |
| 2 | Role of Dopaminergic Receptors in Glaucomatous Disease Modulation显示文摘 | Nicola Pescosolido Francesco Parisi Paola Russo Giuseppe Buomprisco Marcella Nebbioso Paolo Fogagnolo | 2013 | <journal-title>BioMed Research International2013，，： | 1 |
| 3 | SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation显示文摘 | Luigi Sansone Valentina Reali Laura Pellegrini Lidia Villanova Michele Aventaggiato Gabriella Marfe Roberta Rosa Marcella Nebbioso Marco Tafani Massimo Fini Matteo A. Russo Bruna Pucci | 2013 | J Cell Physiol2013，，8： | 1 |
| 4 | Lipoic acid inanimal models and clinical use in diabetic retinopathy显示文摘 | Marcella Nebbioso Federica Pranno Nicola | 2013 | Expert OpinPharmacother2013，4，13： | 1 |
| 5 | Trabecular Meshwork in Normal and Pathological Eyes显示文摘 | Nicola Pescosolido Carlo Cavallotti Dario Rusciano Marcella Nebbioso | 2012 | Ultrastructural Pathology2012，，2： | 1 |
| 6 | Cataract Surgery Complications显示文摘 | Nicola Pescosolido Gianfranco Scarsella Marco Tafani Marcella Nebbioso | 2011 | Drugs in R & D2011，，4： | 1 |
| 7 | Neuroretinal dysfunction in patients affected by neurofibromatosis type 1显示文摘AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control group.Each subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf ERG.The 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of OPGs.All participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each eye.The amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf ERG.Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field.RESULTS:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal quadrants.No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls.CONCLUSION:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf ERG.Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be involved.The possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients. | Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso | 2022 | International Journal of Ophthalmology(English edition)2022，15，5： | 0 |
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