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| 1 | Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury显示文摘The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide(CO), biliverdin and iron, has previously been shown to protect grafts from ischemia/reperfusion and rejection.In addition, the products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin, have been shown to exert protective effects in the liver against a number of stimuli, as in chronic hepatitis C and in transplanted liver grafts. Furthermore, the induction of HO-1 expression can protect the liver against damage caused by a number of chemical compounds. More specifically, the CO derived from HO-1-mediated heme catabolism has been shown to be involved in the regulation of inflammation; furthermore, administration of low concentrations of exogenous CO has a protective effect against inflammation. Both murine and human HO-1 deficiencies have systemic manifestations associated with iron metabolism, such as hepatic overload(with signs of a chronic hepatitis) and iron deficiency anemia(with paradoxical increased levels of ferritin).Hypoxia induces HO-1 expression in multiple rodent,bovine and monkey cell lines, but interestingly, hypoxia represses expression of the human HO-1 gene in a variety of human cell types(endothelial cells, epithelial cells, T cells). These data suggest that HO-1 and CO are promising novel therapeutic molecules for patients with inflammatory diseases. In this review, we present what is currently known regarding the role of HO-1 in liver injuries and in particular, we focus on the implications of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against chemically induced injury. | Clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara | 2013 | World Journal of Hepatology2013，5，10： | 17 |
| 2 | Intestinal barrier: A gentlemen's agreement between microbiota and immunity显示文摘Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine,specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses.The diversity and the composition of the microbiota,thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junctionproteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review,we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier. | Andrea Moro Caricilli Angela Castoldi Niels Olsen Saraiva Cmara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，1： | 11 |
| 3 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 4 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 5 | Nutritional characterization of tomato fiber as a useful ingredient for food industry显示文摘 | P. García Herrera M.C. Sánchez-Mata M. Cámara | 2010 | Innovative Food Science and Emerging Technologies2010，，4： | 1 |
| 6 | Feed form and energy concentration of the diet affect growth performance and digestive tract traits of brown-egg laying pullets from hatching to 17 weeks of age显示文摘 | Saldana B Guzmán P Cámara L | 2015 | Poult Sci2015，94，8： | 1 |
| 7 | S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial显示文摘 | Mato JM Cámara J Fernández de Paz J | 1999 | J Hepatol1999，30，6： | 1 |
| 8 | Phase-space tomography with a programmable Radon-Wigner display显示文摘 | Cámara A Alieva T Rodrigo J A | 2011 | Optics letters2011，36，13： | 1 |
| 9 | Planarization by CMP: Forecasting the Future 显示文摘 | O'mara W C | 1994 | Semiconductor International1994，17，8： | 1 |
| 10 | Structural and functional properties of soy protein isolate and Cod gelatin blend films 显示文摘 | Gabriela A Denavi Miriam Perez-Mateos Mara C Anon | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 11 | A rapid and novel alternative to conventional sample treatment for arsenic speciation in rice using enzymatic ultrasonic probe显示文摘 | E SANZ R MNOZ-OLIVAS C CáMARA | 2005 | Analytica Chimica Acta2005，，535： | 1 |
| 12 | Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu显示文摘 | Cássia Regina Primila Cardoso Ilce Mara de Syllos Cólus Caroline Cristiane Bernardi Miriam Sannomiya Wagner Vilegas Eliana Aparecida Varanda | 2006 | Toxicology2006，，1： | 1 |
| 13 | Extending shelf-life and nutritive value of green beans(Phaseolus Vulgaris L ),by controlled atmosphere storage:macronutrients显示文摘 | Sánchez-Mata MC Cámara M D | | 0，，03： | 1 |
| 14 | Yeast killer system 显示文摘 | Magliani W Stefania C Mara G | 1997 | Clinical Microbiology Reviews1997，10，： | 1 |
| 15 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 16 | The medial sural artery perforator free flap显示文摘 | Cavadas PC Sanz-Gimenéz-Rico JR Gutierrez-de la Cámara A | | 0，，： | 1 |
| 17 | Regulatory mechanisms for floral homeotic gene expression 显示文摘 | Liu Z Mara C | 2010 | Semin Cell Dev Biol2010，21，1： | 1 |
| 18 | Effect ofvicriviroc on the QT/corrected QT interval and central nervous system in healthy subjects 显示文摘 | O'mara E Kasserra C Huddlestone JR | 2010 | Antimicrob Agents Chemother2010，54，6： | 1 |
| 19 | Impacts ofstress and disturbance factors on the phytoplankton communities inNortheastern Brazil reservoir显示文摘 | CHELLAPPA N T CHELLAPPA T C MARA F R A | 2009 | Limnologica2009，39，： | 1 |
| 20 | Planarization by CMP:Forecasting the Future显示文摘 | O'mara W C | 1994 | Semiconductor International1994，17，8： | 1 |
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