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| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | The effects of high CO2levels on anthocyanin composition,antioxidant activity and soluble sugar content of strawberries stored at low non-freezing temperature显示文摘 | Oscar G B María B María T S | 2010 | Food Chemistry2010，122，3： | 1 |
| 3 | Crystal structure and DNA interaction of the facial-type rac-tris[2-(aminomethyl) benzimidazole] cobalt(Ⅲ) complex显示文摘 | JORDI G S MARíA J P MERCèF B | | 0，，25： | 1 |
| 4 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 5 | Characterisation andphotocatalytic properties of titania-silica mixed oxides doped withAg and Pt显示文摘 | Llano B Restrepo G Marín J M | 2010 | Applied Catalysis A:General2010，387，12： | 1 |
| 6 | Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia 显示文摘 | Mar B G Bullinger L Basu E | 2012 | Leukemia2012，26，8： | 1 |
| 7 | Study on nonenzymatic browning in cookies, crackers and breakfast cereals by maltulose and furosine determination显示文摘 | MAITE R M JUANLUIS G B MAR V AGUSTIN O | 2004 | J Cereal Sci2004，39，2： | 1 |
| 8 | Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles显示文摘The use of mesenchymal stem-cells(MSC)in cell therapy has received considerable attention because of their properties.These properties include high expansion and differentiation in vitro,low immunogenicity,and modulation of biological processes,such as inflammation,angiogenesis and hematopoiesis.Curiously,the regenerative effect of MSC is partly due to their paracrine activity.This has prompted numerous studies,to investigate the therapeutic potential of their secretome in general,and specifically their extracellular vesicles(EV).The latter contain proteins,lipids,nucleic acids,and other metabolites,which can cause physiological changes when released into recipient cells.Interestingly,contents of EV can be modulated by preconditioning MSC under different culture conditions.Among them,exposure to hypoxia stands out;these cells respond by activating hypoxia-inducible factor(HIF)at low O_(2) concentrations.HIF has direct and indirect pleiotropic effects,modulating expression of hundreds of genes involved in processes such as inflammation,migration,proliferation,differentiation,angiogenesis,metabolism,and cell apoptosis.Expression of these genes is reflected in the contents of secreted EV.Interestingly,numerous studies show that MSC-derived EV conditioned under hypoxia have a higher regenerative capacity than those obtained under normoxia.In this review,we show the implications of hypoxia responses in relation to tissue regeneration.In addition,hypoxia preconditioning of MSC is being evaluated as a very attractive strategy for isolation of EV,with a high potential for clinical use in regenerative medicine that can be applied to different pathologies. | Victoria Pulido-Escribano Bárbara Torrecillas-Baena Marta Camacho-Cardenosa Gabriel Dorado MaríaÁngeles Gálvez-Moreno Antonio Casado-Díaz | 2022 | World Journal of Stem Cells2022，14，7： | 1 |
| 9 | Antibiotics for bronchiolitis in children显示文摘 | SPURLING G K DOUST J DEL MAR C B | 2011 | Cochrane Database Syst Rev2011，6，00： | 1 |
| 10 | Capillary electrophoresis of free fatty acids by indirect ultraviolet显示文摘 | María V B Aaron E D María J L G | 2011 | Journal of Agricultural and Food Chemistry2011，59，10： | 1 |
| 11 | A method for the selection of production media for actinemycete strains based on their metabolite HPLC profiles显示文摘 | Jose R T Juan B G Mar D A | 2003 | J Ind Microbiol Biotechsol2003，30，： | 1 |
| 12 | Numerical experiments in revisited brittle fracture显示文摘 | BOURD1N B FRANCFORT G A MAR/GO J J | 2000 | Journal of the Mechanics and Physics of Solids2000，48，4： | 1 |
| 13 | Dietary manaesium improves endothelial de pendent relaxation of balloon injured arteries in rats显示文摘 | Fonseca F A Paiva T B Silva E G lhara S S Kasinski N Mar tinez T L | 1998 | Atheroselerosis1998，139，： | 1 |
| 14 | Bimaxillary surgery in ClassⅢmalocclusion:Soft and hard tissue changes显示文摘 | Aydil B zer N Marξan G | 2013 | J Craniomaxillofac Surg2013，41，3： | 1 |
| 15 | Applica-tions and advantages of virus-induced gene silencing for gene function studies in plants显示文摘 | BURCH-SMITH 丁 M ANDERSON J C MAR丁IN G B | 2004 | The Plant Journal2004，39，5： | 1 |
| 16 | Factors influencing the chemical vapor deposition of oriented ZnO films us ing zinc acetate 显示文摘 | TIMBRELL P Y LAMN B R N | 1995 | Chem Mater1995，7，10： | 1 |
| 17 | Fuzzy Compromise Programming for Portfolio Selection显示文摘 | AMELIA B T BLANCA P G MAR A P | 2006 | Applied Mathematics and Computation2006，173，： | 1 |
| 18 | Use of an in-vitro digestion method to evaluate the bio-accessibility of arsenic in edible seaweed by inductively coupled plasma-mass spectrometry显示文摘 | Cristina G S Vanessa R H María C B | 2011 | Microchemical Journal2011，98，： | 1 |
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